Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.400 GeneticVariation disease BEFREE Analyses of the HLA-DRB1*04 cohort in the absence of HLA-DRB1*15:01 haplotypes revealed that the HLA-DQB1*03:01:01:01~HLA-DQA1*03:03:01:01~HLA-DRB1*04:01:01:01SG~HLA-DRB4*01:03:01:01 haplotype was protective (OR = 0.64, p = 0.028), whereas the HLA-DQB1*03:02:01~HLA-DQA1*03:01:01~HLA-DRB1*04:01:01:01SG~HLA-DRB4*01:03:01:01 haplotype was associated with MS susceptibility (OR = 1.66, p = 4.9E-03). 29683085 2019
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.400 Biomarker disease BEFREE Stratification of patients with presence of oligoclonal bands (OCB) showed an association to the HLA-DQB1*06:02-HLA-DRB1*15:01 haplotype in ION (HLA-DQB1*06:02 and HLA-DRB1*15:01 (p = 0.03)), and in MS-ON patients (HLA-DQB1*06:02 and HLA-DRB1*15:01 (p = 0.03)). 29544193 2018
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.400 GeneticVariation disease BEFREE The HLA-DRB1 and HLA-DQB1 alleles are associated with multiple sclerosis disability progression in Slovak population. 29619906 2018
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.400 GeneticVariation disease BEFREE The HLA-DQB1*06:02 allele alone was not sufficient to cause MS patients to develop narcolepsy. 28658402 2017
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.400 GeneticVariation disease BEFREE An association with MS was found for the HLA-DRB1*15 (odds ratio [OR] 2.60 [95% confidence interval (CI) 1.51-4.50]) and HLA-DQB1*06 (OR 1.97 [95% CI 1.18-3.29]) alleles, and for haplotype DRB1*15-DQB1*06 (OR 2.63 [95% CI 1.52-4.56]). 27797002 2017
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.400 GeneticVariation disease BEFREE Several alleles had statistical correlation, but after Bonferroni correction, the only allele with significance was the HLA-DQB1*02:03, which has a positive association with MS. 27556370 2016
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.400 Biomarker disease BEFREE Since there are no data with respect to the correlation of HLA-DQB1*0602 and multiple sclerosis in Khuzestan province, and because of ethnic diversity in Khuzestan province, the aim was to examine the association of this allele with multiple sclerosis in Khuzestan. 26443252 2015
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.400 GeneticVariation disease BEFREE The association of HLA-DRB1 and HLA-DQB1 alleles with genetic susceptibility to multiple sclerosis in the Slovak population. 26744784 2015
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.400 GeneticVariation disease BEFREE None of the HLA-DQB1 alleles were associated with MS. 23771490 2013
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.400 GeneticVariation disease BEFREE The frequency of HLA-DQB1*0402 allele was increased in NMO (p after Bonferroni correction, cp < 0.035) and the HLA-DRB1*15 and DQB1*06 alleles were increased in MS (cp < 0.0027, cp < 0.01), compared to controls. 21908482 2012
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.400 GeneticVariation disease BEFREE The influence of the HLA-DRB1 and HLA-DQB1 allele heterogeneity on disease risk and severity in Iranian patients with multiple sclerosis. 22404765 2012
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.400 Biomarker disease BEFREE The HLA-DRB1*1501- and HLA-DQB1*0602-Tg mice (MHC-II(-/-)), and control non-HLA-DR15-relevant-Tg mice were immunized with a set of overlapping PLP peptides or with recombinant soluble PLP for induction of "humanized" MS-like disease, as well as for ex-vivo analysis of immunogenic/immunodominant HLA-restricted T-cell epitopes and associated cytokine secretion profile. 22316121 2012
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.400 GeneticVariation disease BEFREE Opposing association signals with MS were observed for alleles composing the DRB1*0301-DQB1*0201 haplotype: positive association of the HLA-DRB1*0301 allele in Muslims (P(Bonferroni)=0.004, odds ratio (OR)=3.07), and negative association in Christian Arabs (P(Bonferroni)=0.01, OR=0.12), with similar results obtained for HLA-DQB1*0201. 20463743 2010
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.400 GeneticVariation disease BEFREE HLA-DRB1*15 (OR: 2.3; 95% CI: 1.68-3.07; p<0.001) and HLA-DQB1*06 (OR: 2.2; 95% CI: 1.54-3.07; p<0.001) groups as well as DRB1*1501 (OR: 2.6; 95% CI: 1.67-4.02; p<0.001), DRB1*1503 (OR: 2.2; 95% CI: 1.39-3.62; p=0.001) and DQB1*0602 (OR: 2.5; 95% CI: 1.66-3.71; p<0.001) alleles were found to be risk factors for MS. 19896562 2010
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.400 Biomarker disease BEFREE This new humanized model of MS further implicates autoimmunity against MOBP in MS pathogenesis, provides the first evidence of pathogenic HLA-DQ-associated anti-myelin autoimmunity, and is the first to offer a rationale for HLA-DQB1*0602 association with MS. 19648275 2009
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.400 GeneticVariation disease BEFREE HLA-DRB1*15 and HLA-DQB1*0602, nearly always located together on a small ancestral chromosome segment, are strongly MS-associated. 19380721 2009
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.400 GeneticVariation disease BEFREE Multiple sclerosis (MS) is a complex trait in which alleles at or near the class II loci HLA-DRB1 and HLA-DQB1 contribute significantly to genetic risk. 18606010 2008
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.400 GeneticVariation disease BEFREE Multiple sclerosis (MS) is a complex trait in which alleles at or near the class II loci HLA-DRB1 and HLA-DQB1 contribute significantly to genetic risk. 18433881 2008
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.400 Biomarker disease LHGDN Multiple sclerosis in Gypsies from southern Spain: prevalence, mitochondrial DNA haplogroups and HLA class II association. 18312478 2008
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.400 GeneticVariation disease LHGDN HLA-DR15 haplotype and multiple sclerosis: a HuGE review. 17329717 2007
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.400 GeneticVariation disease LHGDN Low frequency of the disease-associated DRB1*15-DQB1*06 haplotype may contribute to the low prevalence of multiple sclerosis in Sami. 17389012 2007
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.400 Biomarker disease LHGDN Ethnicity-dependent association of HLA DRB1-DQA1-DQB1 alleles in Brazilian multiple sclerosis patients. 17489940 2007
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.400 GeneticVariation disease BEFREE Multiple sclerosis (MS) is a complex trait in which alleles at or near the class II loci HLA-DRB1 and HLA-DQB1 contribute significantly to genetic risk. 17845076 2007
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.400 Biomarker disease BEFREE Genetic susceptibility to multiple sclerosis is associated with genes of the major histocompatibility complex (MHC), particularly HLA-DRB1 and HLA-DQB1 (ref.1). 16186814 2005
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.400 GeneticVariation disease LHGDN Mapping multiple sclerosis susceptibility to the HLA-DR locus in African Americans. 14669136 2004