Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3575
Gene Symbol: IL7R
IL7R
0.500 GeneticVariation disease BEFREE IL7R gene polymorphisms which are associated with several autoimmune diseases have also been implicated as a genetic factor for MS following genome-wide association studies. 30443838 2019
Entrez Id: 3575
Gene Symbol: IL7R
IL7R
0.500 Biomarker disease BEFREE Il7r is involved in the pathogenesis of neurodegenerative disorders, such as multiple sclerosis. 29449560 2018
Entrez Id: 3575
Gene Symbol: IL7R
IL7R
0.500 GeneticVariation disease BEFREE No significant association between the IL7RA C/T (rs6897932) and IL12B A1188C (rs3212227) gene polymorphisms and MS susceptibility was observed. 30069682 2018
Entrez Id: 3575
Gene Symbol: IL7R
IL7R
0.500 AlteredExpression disease BEFREE The higher levels of mRNA expression for the sIL-7Rα isoform in MS patients carrying the IL7R*TT genotype is a new finding not previously reported in studies on the genotype-induced effects of IL-7Rα expression in multiple sclerosis. 28865414 2017
Entrez Id: 3575
Gene Symbol: IL7R
IL7R
0.500 GeneticVariation disease BEFREE In all, IL7RA locus polymorphisms could play an important role in the predisposition to MS, which could contribute to a better understanding the pathogenesis of multiple sclerosis. 28446795 2017
Entrez Id: 3575
Gene Symbol: IL7R
IL7R
0.500 GeneticVariation disease BEFREE This study establishes the occurrence of biological epistasis in humans and provides mechanistic insight into the regulation of IL7R exon 6 splicing and its impact on MS risk. 28340352 2017
Entrez Id: 3575
Gene Symbol: IL7R
IL7R
0.500 Biomarker disease BEFREE These findings contribute to our understanding of the role of IL-7R in demyelination, and provide a rationale for the development of IL-7R-based therapies for MS and other demyelinating diseases. 28415697 2017
Entrez Id: 3575
Gene Symbol: IL7R
IL7R
0.500 GeneticVariation disease BEFREE Our aim was to evaluate the expression level and controlling role of lnc-IL-7R in the expression of two variants of IL-7Ra in MS patients versus healthy controls and their correlation with certain clinical features. 28174058 2017
Entrez Id: 3575
Gene Symbol: IL7R
IL7R
0.500 GeneticVariation disease BEFREE This study suggested that the IL7R C allele was associated with an increased risk of MS and larger-scale studies of populations are needed to explore the roles played by the IL7R T244I polymorphism during the pathogenesis of MS. 27188999 2016
Entrez Id: 3575
Gene Symbol: IL7R
IL7R
0.500 GeneticVariation disease BEFREE After exclusion of irrelevant articles, 11 eligible studies were selected, which were analyzed to determine an association between the MS and IL7R rs6897932" genes_norm="3575">T244I polymorphism (rs6897932). 27456877 2016
Entrez Id: 3575
Gene Symbol: IL7R
IL7R
0.500 GeneticVariation disease BEFREE Here, we aimed to evaluate the association of six IL-7 variants (rs1520333, rs1545298, rs4739140, rs6993386, rs7816065, and rs2887502) and one variant of IL-7RA (rs6897932) with NMO and MS among Chinese Han population in southeastern China. 26608987 2015
Entrez Id: 3575
Gene Symbol: IL7R
IL7R
0.500 GeneticVariation disease BEFREE Moreover, we revealed for the first time that rs6897932 in IL7Ra gene is associated with the progression of MS, evaluated by MSSS scores. 25903732 2015
Entrez Id: 3575
Gene Symbol: IL7R
IL7R
0.500 AlteredExpression disease BEFREE We show that memory CD4(+)CD127(lo)FOXP3(+) Treg subsets do not express GzmB, whereas activated, nonregulatory CD4 T cells isolated from patients with multiple sclerosis express higher levels of GzmB than do cells from healthy donors. 25637022 2015
Entrez Id: 3575
Gene Symbol: IL7R
IL7R
0.500 GeneticVariation disease BEFREE The T-allele in the single nucleotide polymorphism rs6897932 in the gene encoding the IL-7 receptor α (IL7RA) is associated with reduced risk of autoimmune diseases including multiple sclerosis and also affects the course of HIV infection. 25421942 2015
Entrez Id: 3575
Gene Symbol: IL7R
IL7R
0.500 GeneticVariation disease BEFREE However, similar to MS, the MGAT1 variant haplotype interacted with CTLA4 (P=0.03), and a combination of IL2RA and IL7RA (P=0.01). 24572742 2014
Entrez Id: 3575
Gene Symbol: IL7R
IL7R
0.500 GeneticVariation disease BEFREE A number of studies with compelling evidence have provided correlation between single nucleotide polymorphisms in interleukin-7 receptor alpha and multiple sclerosis (MS) in several populations. 24166352 2014
Entrez Id: 3575
Gene Symbol: IL7R
IL7R
0.500 GeneticVariation disease BEFREE Further characterization of the effect of IL2RA and IL7R genetic variants in defined MS subtypes is warranted to evaluate the effect of these genes on specific clinical outcomes and to further elucidate the mechanisms of disease onset and progression. 24770783 2014
Entrez Id: 3575
Gene Symbol: IL7R
IL7R
0.500 GeneticVariation disease BEFREE The aim of the present study was to investigate a possible association between IL7R polymorphisms and IDDs such as MS and NMO. 24337176 2014
Entrez Id: 3575
Gene Symbol: IL7R
IL7R
0.500 GeneticVariation disease BEFREE Here we describe linked intronic variants of MGAT5 that are associated with reduced N-glycan branching, CTLA-4 surface expression and MS (p=5.79×10(-9), n=7,741), the latter additive with the MGAT1, IL2RA and IL7RA MS risk variants (p=1.76×10(-9), OR=0.67-1.83, n=3,518). 23351704 2013
Entrez Id: 3575
Gene Symbol: IL7R
IL7R
0.500 GeneticVariation disease BEFREE Our findings indicate that genetic variants of IL7RA result in haplotype-associated differential responsiveness to immunological stimuli that influence MS susceptibility not exclusively by varying levels of sIL-7RA. 23985573 2013
Entrez Id: 3575
Gene Symbol: IL7R
IL7R
0.500 AlteredExpression disease BEFREE We have previously shown in CD4 T cells that IL7Rα haplotypes 1 and 2, but not 4, respond to interferon beta (IFNβ), the most commonly used immunomodulatory drug in MS, and that haplotype 4 (Hap 4) homozygotes have the highest risk of developing MS. We now show that IL7R expression increases in myeloid cells in response to IFNβ, but that the response is haplotype-dependent, with cells from homozygotes for Hap 4 again showing no response. 24147013 2013
Entrez Id: 3575
Gene Symbol: IL7R
IL7R
0.500 GeneticVariation disease GWASCAT Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. 24076602 2013
Entrez Id: 3575
Gene Symbol: IL7R
IL7R
0.500 Biomarker disease BEFREE A central role for T cells in MS is supported by mouse models, association of the major histocompatibility complex region, and association of critical T cell growth regulator genes such as interleukin-2 receptor (IL-2RA) and interleukin-7 receptor (IL-7RA). 22488447 2012
Entrez Id: 3575
Gene Symbol: IL7R
IL7R
0.500 AlteredExpression disease BEFREE Moreover, IL-7Rα membrane expression was significantly increased in MS in naive and memory CD8 (all p < 0.05) with a similar trend in CD8EM (p = 0.055). 22262655 2012
Entrez Id: 3575
Gene Symbol: IL7R
IL7R
0.500 GeneticVariation disease BEFREE The levels of sIL-7Rα increased dose-dependent upon rs6897932 [C] risk allele carriership in both HCs and MS. Next, we hypothesized that lower sIL-7Rα could result in a higher mIL-7Rα to soluble IL-7Rα ratio. 22914435 2012