Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 GeneticVariation group BEFREE Myeloproliferative neoplasms (MPN) associated with ABL1-ETV6 fusions are rare and poorly characterized. 30553471 2018
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 Biomarker group BEFREE Notwithstanding two previous reports of ETV6-LYN fusion in myeloproliferative neoplasms (MPN), we report the first case of this fusion in AML and hence broaden its disease association. 29153093 2017
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 Biomarker group BEFREE There is no systematic screening of myeloproliferative neoplasms; however, the number of ETV6-ABL1-positive cases and the relative incidence of acute lymphoblastic leukemia and myeloproliferative neoplasms suggest that in adulthood ETV6-ABL1 is more common in BCR-ABL1-negative chronic myeloid leukemia-like myeloproliferations than in acute lymphoblastic leukemia. 27229714 2016
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 Biomarker group BEFREE Analysis of serum from TEL-Syk mice reveals an inflammatory cytokine signature reminiscent of that found in the sera from patients and mouse models of myeloproliferative neoplasms. 24116232 2013
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 GeneticVariation group BEFREE Myeloproliferative disorder with eosinophilia and ETV6-ABL gene rearrangement: efficacy of second-generation tyrosine kinase inhibitors. 19394693 2009
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 Biomarker group BEFREE Therapeutically validated oncoproteins in myeloproliferative neoplasms (MPNs) include BCR-ABL in chronic myelogenous leukemia (CML) and a spectrum of PDGFRA/B mutant proteins that are products of intra- (eg, FIP1L1-PDGFRA) or interchromosomal (eg, ETV6-PDGFRB) gene fusions. 19147089 2009
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 GeneticVariation group BEFREE Cytogenetic abnormalities of chromosome 12p involving the TEL/ETV6 gene are observed in a variety of hematopoietic neoplasms including acute leukemias, myelodysplastic syndromes, and myeloproliferative disorders. 18992913 2009
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 AlteredExpression group BEFREE Myeloproliferative disorders (MPD) are stem cell-derived clonal diseases arising as a consequence of acquired aberrations in c-ABL, Janus-activated kinase 2 (JAK2), and platelet-derived growth factor receptor (PDGFR) that generate oncogenic fusion tyrosine kinases (FTK), including BCR/ABL, TEL/ABL, TEL/JAK2, and TEL/PDGFbetaR. 18757400 2008
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 GeneticVariation group BEFREE We report here that FLT3 may contribute to leukemogenesis in a patient with myeloproliferative disorder and a t(12;13)(p13;q12) translocation through generating a fusion gene with the ETS variant gene 6 (ETV6) gene. 16761019 2006
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 Biomarker group BEFREE In summary, AMN107 can inhibit myeloid proliferation driven by TEL-PDGFRbeta and FIP1L1-PDGFRalpha and may be a useful drug for treatment of patients with myeloproliferative disease who harbor these kinase fusions. 16030188 2005
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 Biomarker group BEFREE In contrast, control mice coexpressing with TEL-PDGFRB and a DNA-binding-mutant of AE developed a nontransplantable myeloproliferative disease identical to that induced by TEL-PDGFRB alone. 12881486 2003
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 GeneticVariation group BEFREE The Tel-Abl (ETV6-Abl) tyrosine kinase, product of complex (9;12) translocations in human leukemia, induces distinct myeloproliferative disease in mice. 12036890 2002
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 GeneticVariation group BEFREE Fusion of ETV6 to MDS1/EVI1 as a result of t(3;12)(q26;p13) in myeloproliferative disorders. 9044825 1997
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 GeneticVariation group BEFREE Translocation (12;22) (p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11. 7731705 1995