Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.200 GeneticVariation group BEFREE Chronic Myeloid Leukemia (CML) is a myeloproliferative neoplasm primarily due to the presence of the BCR-ABL fusion gene that produces the constitutively active protein, BCR-ABL. 31837444 2020
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.200 GeneticVariation group BEFREE JAK2V617F is the most common mutation in patients with BCR-ABL negative myeloproliferative neoplasms (MPNs). 31732720 2020
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.200 GeneticVariation group BEFREE Unique Case of Myeloproliferative Neoplasm with Two Rare Clonal Abnormalities: Rare JAK2 Exon 12 Mutation and Rare e14a3 (b3a3) BCR/ABL Fusion Transcript. 30463063 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.200 Biomarker group BEFREE High risk of recurrent venous thromboembolism in BCR-ABL-negative myeloproliferative neoplasms after termination of anticoagulation. 30155552 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.200 Biomarker group BEFREE In BCR-ABL1-negative myeloproliferative neoplasms, myelofibrosis (MF) is either primary (PMF) or secondary (SMF) to polycythemia vera or essential thrombocythemia. 31340059 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.200 Biomarker group BEFREE BCR-ABL1-negative myeloproliferative disorders and chronic myeloid leukaemia are haematologic malignancies characterised by single and mutually exclusive genetic alterations. 30965317 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.200 GeneticVariation group BEFREE Chronic myeloid leukemia is a myeloproliferative disease where cells of myeloid linage display a t(9;22) chromosomal translocation leading to the formation of the BCR/ABL fusion gene and the continuous activation of tyrosine kinases. 31138064 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.200 Biomarker group BEFREE Inflammatory and oncogenic signaling converge in disease evolution of BCR-ABL-negative myeloproliferative neoplasms, clonal hematopoietic stem cell disorders characterized by gain-of-function mutation in JAK2 kinase (JAK2V617F), with highest prevalence in patients with polycythemia vera (PV). 30967632 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.200 Biomarker group BEFREE The discovery of somatic mutations within the gene encoding calreticulin (CALR) in 2013 represented a major milestone in the molecular diagnosis of BCR-ABL negative myeloproliferative neoplasms (MPN). 28340692 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.200 Biomarker group BEFREE This study aimed to elucidate patterns of disease transformation to secondary myelofibrosis (SMF) or secondary acute myeloid leukemia (SAML) and the development of second primary malignancies in South Korean patients with BCR-ABL1-negative myeloproliferative neoplasms (MPNs). 31765478 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.200 GeneticVariation group BEFREE Chronic myeloid leukemia (CML) is a myeloproliferative disorder due to the existence of BCR-ABL fusion protein that allows the cells to keep proliferating uncontrollably. 31413564 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.200 AlteredExpression group BEFREE Chronic myeloid leukemia (CML) is a myeloproliferative disease caused by the constitutive tyrosine kinase (TK) activity of the BCR-ABL1 fusion protein. 31122263 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.200 GeneticVariation group BEFREE Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by the presence of BCR-ABL fusion gene (GenBank accession NC_000022.11). 31206255 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.200 Biomarker group BEFREE Chronic neutrophilic leukemia (CNL) is a BCR-ABL1-negative myeloproliferative neoplasm with notably dismal survival. 30581159 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.200 Biomarker group BEFREE <b>Introduction</b>: The abnormally activated JAK-STAT pathway plays a central role in the pathogenesis of BCR/ABL-negative myeloproliferative neoplasms (MPNs), simultaneously providing a theoretical and clinical basis for the development of small-molecule compounds targeting JAK. 31450973 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.200 AlteredExpression group BEFREE Defining the presence of BCR-ABL transcript in suspected myeloproliferative neoplasm is essential in establishing chronic myeloid leukemia. 30772299 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.200 Biomarker group BEFREE ABSTRACT: Background The BCR-ABL-negative myeloproliferative neoplasms, i.e., polycythemia vera, essential thrombocythemia (ET), and myelofibrosis (MF), are characterized by mutations in JAK2, CALR, or MPL. 30889303 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.200 Biomarker group BEFREE BCR-ABL-negative myeloproliferative neoplasms (MPNs) are driven by JAK-STAT pathway activation, but epigenetic alterations also play an important pathophysiological role. 30769020 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.200 GeneticVariation group BEFREE Starting from this observation, we extended our study to a panel of human leukemic cells carrying genetic lesions distinctive of different types of leukemias and myeloproliferative disorders (the BCR-ABL1 translocation and the JAK2V617F amino acid substitution) to dissect the cellular events induced by SOX6. 30833651 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.200 GeneticVariation group BEFREE Angiogenesis and JAK2 V617F mutation are common in BCR-ABL1 negative myeloproliferative neoplasms (MPNs). 28554272 2018
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.200 Biomarker group BEFREE Thromboembolic events are the main cause of mortality in BCR-ABL1-negative myeloproliferative neoplasms (MPNs) but their underlying mechanisms are largely unrecognized. 30103245 2018
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.200 Biomarker group BEFREE CALR, JAK2 and MPL mutation status in Argentinean patients with BCR-ABL1- negative myeloproliferative neoplasms. 28990497 2018
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.200 GeneticVariation group BEFREE Our data, reflecting the largest reported study comprehensively detailing clinicopathologic features and response to therapy, show that the co-occurrence of BCR-ABL1 and JAK2 V617F is rare, with an estimated frequency of 0.4%, and most often reflects two distinct ('composite') myeloproliferative neoplasms. 29327708 2018
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.200 Biomarker group BEFREE Genetic factors play a role in the etiology of BCR-ABL-negative myeloproliferative neoplasms (MPNs). 30084272 2018
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.200 Biomarker group BEFREE Primary myelofibrosis (PMF) is one of the classic BCR-ABL1 negative myeloproliferative neoplasms (MPN). 29256926 2018