Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.200 GeneticVariation group BEFREE A 2.5-year-old boy was diagnosed with myeloproliferative disorder and eosinophilia associated with lymphoblastic lymphoma both bearing the CCDC88C-PDGFRB fusion. 30726835 2019
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.200 GeneticVariation group BEFREE Although patients with PDGFRB rearrangement mostly present with myeloproliferative neoplasm and eosinophilia, acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) have also been reported in this population. 28000100 2017
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.200 Biomarker group BEFREE We report a NUMA1-PDGFRB fusion in a myeloproliferative neoplasm with eosinophilia in a 61-year old man, with response to imatinib mesylate therapy. 28449810 2017
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.200 GeneticVariation group BEFREE Myeloid neoplasms and eosinophilia with rearrangements of PDGFRB are uncommon Philadelphia-negative myeloproliferative neoplasms. 24687085 2014
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.200 GeneticVariation group BEFREE Myeloproliferative neoplasms associated with FIP1L1-PDGFR rearrangements represent a rare subset of myeloid and lymphoid malignancies, characterised by the presence of eosinophilia and abnormalities of PDGFRA, PDGFRB or FGFR1 genes. 24460680 2014
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.200 Biomarker group BEFREE Here, we developed version 2.0 of a genomically based systematic kinase fusion screen and used it to detect a novel imatinib-sensitive C6orf204-PDGFRB fusion in a patient with precursor T lymphoblastic lymphoma (T-ALL) and an associated myeloproliferative neoplasm with eosinophilia. 21938754 2012
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.200 GeneticVariation group BEFREE The incidence of myeloproliferative neoplasms (MPN) with PDGFRB rearrangement was low (10 cases, 1.8% of all MPN). 22587685 2012
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.200 Biomarker group BEFREE The introduction of JAK2 mutation testing has changed dramatically the diagnostic algorithms for myeloproliferative neoplasms (MPNs) but there is still a place for conventional cytogenetic analysis in the initial work-up of MPN cases, particularly as this group of myeloid disorders has been expanded to include chronic eosinophilic leukaemia and myeloid neoplasms with abnormalities of the PDGFRA, PDGFRB, and FGFR1 genes. 21431636 2011
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.200 Biomarker group BEFREE Important changes include (1) the change of nomenclature of myeloproliferative disorder to myeloproliferative neoplasm emphasizing the clonal nature of these disorders; (2) the classification of mast cell disease as an MPN; (3) the reorganization of the eosinophilic disorders into a molecularly defined category of PDGFRA, PDGFRB and FGFR1-associated myeloid and lymphoid neoplasms with eosinophilia and chronic eosinophilic leukemia, not otherwise specified; and (4) refinement of the diagnostic criteria for PV, ET and PMF incorporating recently described molecular markers, JAK2V617F, JAK2 exon 12 mutations and MPL mutations. 20191332 2010
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.200 GeneticVariation group BEFREE This review highlights the important diagnostic tools in classical and atypical myeloproliferative neoplasms mainly the JAK2V617F mutation, the Mpl receptor, Polycythemia rubra vera 1 (PRV1), platelet-derived growth-factor receptor alpha (PDGFRA), platelet-derived growth-factor receptor beta (PDGFRB), fibroblast growth-factor receptor 1 (FGFR1) and c-kit tyrosine kinase. 20126996 2010
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.200 AlteredExpression group BEFREE Quantitative reverse transcriptase polymerase chain reaction analysis is a simple and useful adjunct to standard diagnostic assays to detect clinically significant overexpression of PDGFRA and PDGFRB in eosinophilia-associated myeloproliferative neoplasms or related disorders. 20107158 2010
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.200 GeneticVariation group BEFREE Identification of a MYO18A-PDGFRB fusion gene in an eosinophilia-associated atypical myeloproliferative neoplasm with a t(5;17)(q33-34;q11.2). 19006078 2009
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.200 AlteredExpression group BEFREE Tel/PDGFRbeta results in constitutive activation of several signaling pathways and induces a myeloproliferative disease in mice, with signals via tyrosines 579/581 identified as being important for this phenotype. 19100521 2009
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.200 Biomarker group BEFREE Therapeutically validated oncoproteins in myeloproliferative neoplasms (MPN) include BCR-ABL1 and rearranged PDGFR proteins.The latter are products of intra- (e.g. 19175693 2009
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.200 GeneticVariation group BEFREE Imatinib is usually a highly effective treatment for myeloproliferative neoplasms (MPNs) associated with ABL, PDGFRA or PDGFRB gene fusions; however, occasional imatinib-responsive patients have been reported without abnormalities of these genes. 18971950 2009
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.200 GeneticVariation group BEFREE Myeloid neoplasms are now classified into five categories: acute myeloid leukemia, myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPN), MDS/MPN, and myeloid and/or lymphoid malignancies associated with eosinophilia and PDGFR or FGFR1 rearrangements. 19806146 2009
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.200 GeneticVariation group BEFREE Therapeutically validated oncoproteins in myeloproliferative neoplasms (MPNs) include BCR-ABL in chronic myelogenous leukemia (CML) and a spectrum of PDGFRA/B mutant proteins that are products of intra- (eg, FIP1L1-PDGFRA) or interchromosomal (eg, ETV6-PDGFRB) gene fusions. 19147089 2009
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.200 AlteredExpression group LHGDN Platelet-derived growth factor may be associated with fibrosis in a Down syndrome patient with transient myeloproliferative disorder. 18331602 2008
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.200 Biomarker group LHGDN Fusion of PRKG2 and SPTBN1 to the platelet-derived growth factor receptor beta gene (PDGFRB) in imatinib-responsive atypical myeloproliferative disorders. 18262053 2008
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.200 GeneticVariation group BEFREE Fusion of PRKG2 and SPTBN1 to the platelet-derived growth factor receptor beta gene (PDGFRB) in imatinib-responsive atypical myeloproliferative disorders. 18262053 2008
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.200 AlteredExpression group LHGDN Characterization of three new imatinib-responsive fusion genes in chronic myeloproliferative disorders generated by disruption of the platelet-derived growth factor receptor beta gene. 17296564 2007
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.200 GeneticVariation group BEFREE KIAA1509 is a novel PDGFRB fusion partner in imatinib-responsive myeloproliferative disease associated with a t(5;14)(q33;q32). 15496975 2005
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.200 GeneticVariation group BEFREE Lack of response to imatinib mesylate in a patient with accelerated phase myeloproliferative disorder with rearrangement of the platelet-derived growth factor receptor beta-gene. 15477214 2004
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.200 GeneticVariation group BEFREE NIN, a gene encoding a CEP110-like centrosomal protein, is fused to PDGFRB in a patient with a t(5;14)(q33;q24) and an imatinib-responsive myeloproliferative disorder. 15087377 2004
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.200 GeneticVariation group BEFREE p53-Binding protein 1 is fused to the platelet-derived growth factor receptor beta in a patient with a t(5;15)(q33;q22) and an imatinib-responsive eosinophilic myeloproliferative disorder. 15492236 2004