Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 Biomarker disease BEFREE The focus of this review is to summarize findings on biomarkers of myocardial fibrosis (PICP and PIIINP), profibrotic mediators (TGF-beta1), extracellular matrix remodeling (MMP-9), myocardial stretch (BNP and NTpro-BNP), inflammation (interleukins, C-reactive protein and sCD40L), and myocardial necrosis (high-sensitivity troponin T), biomarkers, that can be used in clinical practice to stratify patients at risk for POAF. 28748762 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 AlteredExpression disease BEFREE Meanwhile, six genes were identified in both T2DM and MI, which are ADM, NFIL3, PI3, SLPI, ACSL1 and MMP9 and significantly related to "negative regulation of endopeptidase activity". 29890546 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 AlteredExpression disease BEFREE The expression of matrix metalloproteinase 2 (MMP-2), MMP-9, collagen type I, α-smooth muscle actin (α-SMA), and transforming growth factor-β (TGF-β) were upregulated in ISO-induced MI in rats. 30977399 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 AlteredExpression disease BEFREE MMP-9 activity in plasma was increased in OM after MI (3d: p < 0.01). 30763602 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 Biomarker disease BEFREE At last we tested the effect of DHI and three chemical constituents of DHI (danshensu; lithospermic acid, LA; salvianolic acid D, SaD) on EPCs level and expression of Akt, eNOS and MMP-9 in bone marrow cells of myocardial infarction (MI) mice. 31035054 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 AlteredExpression disease BEFREE Aerobic exercise increased levels of serum netrin-1, myocardial netrin-1, and the DCC receptor and reduced the expression of myocardial MMP2 and MMP9 proteins, to improve the degree of fibrosis following myocardial infarction in rats. 30789913 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 Biomarker disease BEFREE Our results showed that ellagic acid significantly reduced protein expression of HDAC1, mRNA expression of collagen I, collagen III, MMP-2 and MMP-9 and the area of cardiac fibrosis in MI rats. 31168029 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 AlteredExpression disease BEFREE Col1a1, col3a1, and MMP9 expression were increased in adult infarcts 3 and 30 days after MI but were upregulated in fetal infarcts only 3 days after MI. 30690019 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 GeneticVariation disease BEFREE We assessed the relationship between the two polymorphisms of the MMP9 gene including R279Q and C1562T and occurrence of premature MI. 28453874 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 Biomarker disease BEFREE Mean plasma MMP9 concentration in patients with MI distinguished between STEMI and NSTEMI (area under curve [AUC] 75% [confidence interval (CI) 60-91], P = 0.006) which was superior to troponin T (AUC 66% [CI 48-85, P = 0.08), predicting STEMI with 80% sensitivity (95% CI 56-94), 90% specificity (CI 68-99), 70% AUC (CI 54-86, P < 0.0001), and NSTEMI with 50% sensitivity (CI 27-70), 90% specificity (CI 68-99), 70% AUC (CI 54-86, P = 0.03). 29274308 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 GeneticVariation disease BEFREE Our meta-analysis suggested that the MMP9 T allele is a risk factor for CAD and MI. 29507703 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 Biomarker disease BEFREE Disease-free centenarians had significantly lower (all p < 0.01) serum biomarker levels than young patients with myocardial infarction (growth differentiation factor 15: 877 ± 299 vs. 1062 ± 358 pg/mL; matrix metalloproteinase (MMP)-1: 1.7 ± 0.9 vs. 3.2 ± 1.2 ng/mL; MMP-2 174 ± 38 vs. 214 ± 44 ng/mL; MMP-9 325 ± 73 vs. 407 ± 54 ng/mL; and carboxy-terminal telopeptide of collagen type I: 3.3 ± 1 vs. 4.2 ± 1.3 ng/mL). 30244779 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 AlteredExpression disease BEFREE Because young transgenic (TG) mice overexpressing human MMP-9 only in macrophages show better outcomes post-MI, whereas aged TG mice show a worse aging phenotype, we wanted to evaluate the effect of aging superimposed on MI to see if the detrimental effect of aging counteracted the benefits of macrophage MMP-9 overexpression. 29030341 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 AlteredExpression disease BEFREE Trimetazidine suppresses oxidative stress, inhibits MMP-2 and MMP-9 expression, and prevents cardiac rupture in mice with myocardial infarction. 30019466 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 AlteredExpression disease BEFREE S100A8/A9 promotes MMP-9 expression in the fibroblasts from cardiac rupture after myocardial infarction by inducing macrophages secreting TNFα. 29949169 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 Biomarker disease BEFREE Sphingosine 1-phosphate promotes mesenchymal stem cell-mediated cardioprotection against myocardial infarction via ERK1/2-MMP-9 and Akt signaling axis. 30367841 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 Biomarker disease BEFREE We found that FP treatment improved heart function, reduced cardiac fibrosis, and downregulated the expression of fibrosis-related factors including collagen I, collagen III, matrix metalloproteinase-2 (MMP-2), MMP-9, transforming growth factor-<i>β</i>1 (TGF-<i>β</i>1), and p-Smad2/3, which coincided with the upregulated expression of silent information regulator 1 (SIRT1) in the hearts of MI rats. 30050588 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 AlteredExpression disease BEFREE Increased expression of α-smooth muscle actin and collagen I/III was observed, whereas the levels of matrix metalloproteinase-2 and matrix metalloproteinase-9 were decreased in the hearts of Dectin-2 knockout mice after MI. 28193608 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 GeneticVariation disease BEFREE The TT variants of -1562C/T MMP-9 and at least one T allele of +92C/T MMP-13 were considered in a trend to affect disease progression and long-term survival after myocardial infarction. 28101856 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 Biomarker disease BEFREE Immunofluorescence intensity for MMP-9 was enhanced in the LVs, but was less so in MI+SR than in MI+V. 29232411 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 Biomarker disease BEFREE LRP1 also colocalized with proline-rich tyrosine kinase 2 (pPyk2) and MMP-9 in cardiac fibroblasts in ischaemic areas at 10 and 21 days after MI. 28378397 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 AlteredExpression disease BEFREE In conclusion, a higher MMP-9 level is an independent predictor of in-hospital death in AMI patients who received emergency PCI. 29285294 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 AlteredExpression disease BEFREE These improvements were associated with decreased expression of matrix metalloproteinase 9, the cardiac stress genes for natriuretic peptides (atrial natriuretic peptide and brain natriuretic peptide), and β-myosin heavy chain after MI. 28148779 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 GeneticVariation disease BEFREE Furthermore, multiple logistic regression analysis indicated that the individuals with the TT genotype of the MMP-9-1562C>T polymorphism were significantly protected against MI in comparison with the CC genotype (OR: 0.01, 95% CI: 0.002-0.68, p = 0.03). 27824519 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 Biomarker disease BEFREE Systemic MMP9 elevation is independent of the associated myocardial necrosis and systemic inflammation (measured by Troponin I and C-reactive protein, respectively). 28642677 2017