Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.600 AlteredExpression disease BEFREE Furthermore, compared with the MI group, the plasma levels of TXA2, ET-1 and vWF contents signififi cantly decreased in the MI+SSYX group, and the ET-1 mRNA expression levels of myocardium in the border zone significantly decreased, and the VEGF, PGI2 and eNOS mRNA expression levels signififi cantly increased (all P<0.05). 30656600 2019
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.600 AlteredExpression disease BEFREE This study explored whether pravastatin decreases myocardial infarct size and this effect is associated with endothelial nitric oxide synthase (eNOS) expression in myocardium. 29375110 2018
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.600 Biomarker disease BEFREE Exercise Training Has Contrasting Effects in Myocardial Infarction and Pressure Overload Due to Divergent Endothelial Nitric Oxide Synthase Regulation. 29986381 2018
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.600 AlteredExpression disease BEFREE Results showed reduced endothelial nitric oxide synthase (eNOS) protein expression in the MI group; increased iNOS activity in the HgCl<sub>2</sub>-MI group, although without enough magnitude to reverse the reduction in NO bioavailability; and increased phenylephrine response in the HgCl<sub>2</sub>-MI group due to an increase in ROS production, notably via xanthine oxidase (XO). 28980197 2018
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.600 GeneticVariation disease BEFREE Multilocus analysis additionally suggested the influence of carriage of the CRP and ENOS genes variants at the development of subsequent adverse events after MI. 29331485 2018
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.600 Biomarker disease RGD Results showed reduced endothelial nitric oxide synthase (eNOS) protein expression in the MI group; increased iNOS activity in the HgCl<sub>2</sub>-MI group, although without enough magnitude to reverse the reduction in NO bioavailability; and increased phenylephrine response in the HgCl<sub>2</sub>-MI group due to an increase in ROS production, notably via xanthine oxidase (XO). 28980197 2018
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.600 GeneticVariation disease BEFREE Pooled odds ratios (OR) with 95% confidence interval (CI) were calculated to evaluate the association of eNOS gene T-786C and 4b4a polymorphisms with MI risk. 28188309 2017
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.600 Biomarker disease BEFREE The impact of eNOS activation on pro- and anti-apoptotic signalling in the remote myocardium and the influence of pretreatment with the eNOS cofactor tetrahydrobiopterin (BH4) on eNOS activation, nitrosative stress level, and apoptosis induction and execution were studied in a rat MI model in vivo. 28832096 2017
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.600 GeneticVariation disease BEFREE Using APSampler software, we found composite markers associated with MI only in patients with early onset: FGB rs1800788*T + TGFB1 rs1982073*T; FGB rs1800788*T + LPL rs328*C + IL4 rs2243250*C; FGB rs1800788*T + ENOS rs2070744*C (Fisher p values of 1.4 × 10<sup>-6</sup> to 2.2 × 10<sup>-5</sup>; the permutation p values of 1.1 × 10<sup>-5</sup> to 3.0 × 10<sup>-4</sup>; ORs = 2.67-2.54). 28685248 2017
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.600 GeneticVariation disease BEFREE Further analysis with the inclusions of gene-gene and gene-environmental interactions shows interactions between rs17231896 (CETP) and rs17222772 (ALOX); rs17231896 (CETP) and gender. rs17237890 (CETP) and rs2070744 (NOS3) are found to be significantly associated with risks of MI adjusted by both SNPs and environmental factors. 28906356 2017
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.600 Biomarker disease BEFREE By comparing mice with global overexpression of Trx and mice with cardiomyocyte-specific overexpression of Trx, we demonstrate that vascular Trx-mediated deglutathionylation of eNOS protects against ischemia-reperfusion-mediated myocardial infarction. 27587398 2016
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.600 Biomarker disease BEFREE Age and CAD impair multiple functions of CACs and limit therapeutic potential for the treatment of MI. eNOS gene therapy in CACs from older donors or those with CAD has the potential to improve autologous cell therapy outcomes. 26738788 2016
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.600 GeneticVariation disease BEFREE In order to find new informative predictors of myocardial infarction, we performed an analysis of genotype frequencies of polymorphic markers of SELE (rs2076059, 3832T > C), SELP (rs6131, S290 N), SELL (rs1131498, rs1131498" genes_norm="6402">F206L), ICAM1 (rs5498, K469E), VCAM1 (rs3917010, c.928 + 420A > C), PECAM1 (rs668, V125L), VEGFA (rs35569394, -2549(18)I/D), CCL2 (rs1024611, -2518A > G), NOS3 (rs1799983, E298D), and DDAH1 (rs669173, c.303 + 30998A > G) genes in the group of Russian men with myocardial infarction (N = 315) and the control group of corresponding ethnicity, gender, and age (N = 286). 26662939 2016
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.600 GeneticVariation disease BEFREE Endothelial nitric oxide synthase genotypes modulate peripheral vasodilatory properties after myocardial infarction. 26002446 2015
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.600 GeneticVariation disease BEFREE The results indicate that ethnicity plays important roles in the association between eNOS G894T polymorphism and MI. 24498040 2014
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.600 GeneticVariation disease BEFREE There appeared to be a significant difference in the genotype and allele distribution of eNOS T-786C polymorphism between T2DM groups with and without CAD (p=0.004), albeit no significant association with MI was observed. 23182401 2013
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.600 GeneticVariation disease BEFREE The present study showed lack of association between NOS3 gene polymorphisms and MI in South Indian population. 23108994 2013
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.600 GeneticVariation disease BEFREE A significantly higher frequency of homozygosity for the 786C (32%) and the 894T (21%) alleles of the eNOS gene in patients who develop early MI in the setting of angiographically 'normal' or 'near normal' coronary arteries were found. 23594558 2013
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.600 GeneticVariation disease BEFREE The multivariate analysis, adjusted for traditional cardiovascular risk factors, revealed that the NOS3 4a4a genotype was an independent predisposing factor to MI, according to the models considered. 24095258 2013
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.600 GeneticVariation disease BEFREE We hypothesized that the NOS3 synthase 4a4b VNTR polymorphism is a determinant of tHcy concentrations and tested this in 310 patients with MI and 250 controls. 22652373 2012
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.600 Biomarker disease RGD The results showed that post-MI exposure of rats to daily cycles of hyperoxygenation (oxygen cycling) improved stem cell engraftment, cardiac function, and increased NOS3 expression. 22012955 2012
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.600 GeneticVariation disease BEFREE Accordingly, we examined a possible association between the E298D polymorphism of the eNOS gene and MI in a subgroup of the Greek population. 20854685 2010
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.600 Biomarker disease BEFREE These results demonstrate that the eNOS/NO system provides cardiac protection after MI injury through inhibition of inflammation and suppression of MAPK signaling. 19908164 2010
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.600 GeneticVariation disease BEFREE We have identified polymorphisms in the NOS 3 gene and one of these polymorphisms, Glu(298-->)Asp, was found to be a major risk factor for carotid artery disease and myocardial infarction. 19330466 2009
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.600 GeneticVariation disease BEFREE Cases (all-cause death, nonfatal myocardial infarction (MI), or nonfatal stroke) and an age-, sex-, race/ethnicity-matched control population were genotyped for the -786T>C and Glu298>Asp polymorphisms in NOS3. 19407804 2009