Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.800 Biomarker disease BEFREE The association between narcolepsy and human leukocyte antigen HLA- DQB1*06:02 has been established elsewhere but remains to be investigated among Saudi Arabian patients with narcolepsy. 30187366 2019
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.800 GeneticVariation disease BEFREE Carrying HLA-DQB1*06:02 was significantly associated with narcolepsy, odds ratio (OR) 39.4 [95% confidence interval (CI) 11.3, 137], p = 7.9 × 10<sup>-9</sup>. 30711515 2019
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.800 Biomarker disease BEFREE HLA-DQB1*0602 forms a heterodimer with HLA-DQA1*0102 and may act as an antigen presenter to the T cell receptors, resulting in narcolepsy susceptibility. 28108192 2018
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.800 Biomarker disease BEFREE Correlation between HLA-DQB1*06:02 and narcolepsy with and without cataplexy: approving a safe and sensitive genetic test in four major ethnic groups. A systematic meta-analysis. 30321823 2018
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.800 GeneticVariation disease BEFREE The HLA-DQB1*06:02 allele alone was not sufficient to cause MS patients to develop narcolepsy. 28658402 2017
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.800 GeneticVariation disease BEFREE Our study aimed to determine the prevalence of HLA-DQB1*0602 allele in Iranian patients with narcolepsy and assess its predictive parameters for diagnosing narcolepsy. 29149785 2017
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.800 Biomarker disease GENOMICS_ENGLAND Familial Kleine-Levin Syndrome: A Specific Entity? 27253765 2016
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.800 Biomarker disease BEFREE Polygenic risks in narcolepsy were estimated to explain 58.1% (P<sub>HLA-DQB1*06:02</sub>=2.30 × 10<sup>-48</sup>, P<sub>whole genome without HLA-DQB1*06:02</sub>=6.73 × 10<sup>-2</sup>) including HLA-DQB1*06:02 effects and 1.3% (P<sub>whole genome without HLA-DQB1*06:02</sub>=2.43 × 10<sup>-2</sup>) excluding HLA-DQB1*06:02 effects. 27305985 2016
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.800 GeneticVariation disease BEFREE In the present study, HLA-DQB1 in 664 Japanese narcoleptic subjects and 3131 Japanese control subjects was examined to determine whether HLA-DQB1 alleles located in trans of DQB1*06:02 are associated with narcolepsy. 25256355 2015
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.800 Biomarker disease BEFREE In this paper, we extend an analysis of the effect of HLA-DQB1 on narcolepsy risk published recently by Tafti et al. 25325462 2015
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.800 GeneticVariation disease BEFREE Genetic studies confirmed the association with the allele HLA-DQB1*06:02, which is known to be related to sporadic narcolepsy. 26123389 2015
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.800 Biomarker disease GENOMICS_ENGLAND An association analysis of HLA-DQB1 with narcolepsy without cataplexy and idiopathic hypersomnia with/without long sleep time in a Japanese population. 27081540 2015
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.800 GeneticVariation disease BEFREE This comprehensive genetic study sought to assess variations in CHKB and CPT1B susceptibility genes and HLA-DQB1*06:02 allele status in Turkish patients with narcolepsy and healthy persons. 24571861 2014
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.800 Biomarker disease BEFREE HLA DQB1*06:02 negative narcolepsy with hypocretin/orexin deficiency. 25197808 2014
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.800 GeneticVariation disease GWASCAT Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic. 24204295 2013
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.800 GeneticVariation disease BEFREE Our data add further support to the strong association of the HLA-DQB1(∗)06:02 allele with narcolepsy, especially in narcolepsy+cataplexy patients. 24157097 2013
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.800 Biomarker disease BEFREE This diagnosis was defined as narcolepsy associated with cataplexy plus HLA-DQB1*06:02 positivity (no cerebrospinal fluid hypocretin-1 results available) or narcolepsy with documented low (≤ 110 pg/mL) cerebrospinal fluid hypocretin-1 level. 23649748 2013
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.800 GeneticVariation disease BEFREE Narcolepsy is strongly associated with the HLA DQB1*0602 allele, and its symptoms stem from destruction of hypocretin-secreting neurons in the hypothalamus. 22213222 2012
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.800 Biomarker disease BEFREE We investigated the association between birth order and narcolepsy risk in a population-based case-control study in which all study subjects were HLA-DQB1*0602 positive. 22281000 2012
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.800 Biomarker disease BEFREE HLA DQB1*0602 is found in most individuals with hypocretin-deficient narcolepsy, a disorder characterized by a severe disruption of sleep and wake. 21292329 2011
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.800 GeneticVariation disease BEFREE Narcolepsy symptom severity varies in a linear manner according to HLA-DQB1*0602 allele status. 20120618 2010
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.800 Biomarker disease CTD_human Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy. 20711174 2010
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.800 GeneticVariation disease BEFREE Prevalence of the HLA-DQB1*0602 allele in narcolepsy and idiopathic hypersomnia patients seen at a sleep disorders outpatient unit in São Paulo. 19506770 2009
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.800 GeneticVariation disease BEFREE Passive smoking may be a risk factor for narcolepsy in subjects with HLA DQB1*0602. 19039244 2009
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.800 GeneticVariation disease BEFREE For narcolepsy with HLA-DQB1 *0602, prevalence was 15.3 (95% CI: 12.8-17.9). 19013100 2009