Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9971
Gene Symbol: NR1H4
NR1H4 		0.300 Therapeutic phenotype CTD_human Phosphorylation of hepatic farnesoid X receptor by FGF19 signaling-activated Src maintains cholesterol levels and protects from atherosclerosis. 30996006 2019
Entrez Id: 112724
Gene Symbol: RDH13
RDH13 		0.300 Biomarker phenotype CTD_human Retinol dehydrogenase 13 deficiency diminishes carbon tetrachloride-induced liver fibrosis in mice. 27865848 2017
Entrez Id: 2597
Gene Symbol: GAPDH
GAPDH 		0.300 Therapeutic phenotype CTD_human GAPDH-knockdown reduce rotenone-induced H9C2 cells death via autophagy and anti-oxidative stress pathway. 25725130 2015
Entrez Id: 196
Gene Symbol: AHR
AHR 		0.300 Biomarker phenotype CTD_human Aryl hydrocarbon receptor is necessary to protect fetal human pulmonary microvascular endothelial cells against hyperoxic injury: Mechanistic roles of antioxidant enzymes and RelB. 25831079 2015
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2 		0.300 Therapeutic phenotype CTD_human Nrf2 protects against furosemide-induced hepatotoxicity. 24813929 2014
Entrez Id: 6418
Gene Symbol: SET
SET 		0.300 Biomarker phenotype CTD_human Stable SET knockdown in head and neck squamous cell carcinoma promotes cell invasion and the mesenchymal-like phenotype in vitro, as well as necrosis, cisplatin sensitivity and lymph node metastasis in xenograft tumor models. 24555657 2014
Entrez Id: 406967
Gene Symbol: MIR192
MIR192 		0.300 Biomarker phenotype CTD_human Urinary microRNA profiling for identification of biomarkers after cisplatin-induced kidney injury. 24880025 2014
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.300 Biomarker phenotype CTD_human Nonetheless, WT MEF were more sensitive to TNFα-induced death which was attributed to necrosis. 24548419 2014
Entrez Id: 26762
Gene Symbol: HAVCR1
HAVCR1 		0.300 Biomarker phenotype CTD_human Urinary microRNA profiling for identification of biomarkers after cisplatin-induced kidney injury. 24880025 2014
Entrez Id: 3605
Gene Symbol: IL17A
IL17A 		0.300 Biomarker phenotype CTD_human Interleukin-17 mediates triptolide-induced liver injury in mice. 24949944 2014
Entrez Id: 1756
Gene Symbol: DMD
DMD 		0.300 Biomarker phenotype CTD_human Resveratrol decreases inflammation and increases utrophin gene expression in the mdx mouse model of Duchenne muscular dystrophy. 22795790 2013
Entrez Id: 1489
Gene Symbol: CTF1
CTF1 		0.300 Therapeutic phenotype CTD_human Cardiotrophin-1 administration prevents the renal toxicity of iodinated contrast media in rats. 23335628 2013
Entrez Id: 6678
Gene Symbol: SPARC
SPARC 		0.300 Biomarker phenotype CTD_human Lack of the matricellular protein SPARC (secreted protein, acidic and rich in cysteine) attenuates liver fibrogenesis in mice. 23408952 2013
Entrez Id: 613
Gene Symbol: BCR
BCR 		0.300 Biomarker phenotype CTD_human Disrupting BCR-ABL in combination with secondary leukemia-specific pathways in CML cells leads to enhanced apoptosis and decreased proliferation. 23211037 2013
Entrez Id: 384
Gene Symbol: ARG2
ARG2 		0.300 Biomarker phenotype CTD_human In contrast to prostate cancer, ARG2 expression was rarely demonstrated in PDC cells by immunohistochemistry, and instead ARG2 was characteristically expressed in α-smooth muscle actin-positive cancer-associated fibroblasts (CAFs), especially those located within and around necrotic areas in PDC. 23424623 2013
Entrez Id: 2628
Gene Symbol: GATM
GATM 		0.300 Biomarker phenotype CTD_human Integrated transcriptomic and proteomic evaluation of gentamicin nephrotoxicity in rats. 22061828 2012
Entrez Id: 959
Gene Symbol: CD40LG
CD40LG 		0.300 Biomarker phenotype CTD_human The inhibition of c-Jun N-terminal Kinase and p38 attenuated CD154-mediated apoptosis but not necrosis. 22295117 2012
Entrez Id: 3958
Gene Symbol: LGALS3
LGALS3 		0.300 Biomarker phenotype CTD_human Immunohistochemical analysis showed that Gal-3 was predominantly expressed by mononuclear cells infiltrating into necrotic areas. 22461450 2012
Entrez Id: 5950
Gene Symbol: RBP4
RBP4 		0.300 Biomarker phenotype CTD_human Integrated transcriptomic and proteomic evaluation of gentamicin nephrotoxicity in rats. 22061828 2012
Entrez Id: 6915
Gene Symbol: TBXA2R
TBXA2R 		0.300 Biomarker phenotype CTD_human Thromboxane A(2) receptor signaling promotes liver tissue repair after toxic injury through the enhancement of macrophage recruitment. 22206755 2012
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.300 Biomarker phenotype CTD_human TNF-α treatment of primary human lung epithelia and A549 cells induced ZIP8 expression, resulting in significantly higher cell death attributable to both apoptosis and necrosis following Cd exposure. 22345571 2012
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1 		0.300 Biomarker phenotype CTD_human High mobility group box 1 (HMGB1) protein is secreted by activated cells of the innate immune system and/or released by injured tissues and necrotic cells; HMGB1 up-regulates proinflammatory cytokines in several inflammatory diseases. 22178603 2012
Entrez Id: 1508
Gene Symbol: CTSB
CTSB 		0.300 Biomarker phenotype CTD_human The regulation of cysteine cathepsins and cystatins in human gliomas. 22287159 2012
Entrez Id: 351
Gene Symbol: APP
APP 		0.300 Biomarker phenotype CTD_human Protective effects of ω-conotoxin on amyloid-β-induced damage in PC12 cells. 21839817 2011
Entrez Id: 10533
Gene Symbol: ATG7
ATG7 		0.300 Therapeutic phenotype CTD_human Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition. 21081844 2011