Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE In this study we have determined the prevalence of amplification of the proto-oncogenes c-erb B1 (= epidermal growth factor receptor gene), c-erb B2 and c-myc in 44 human intracranial tumours (27 gliomas, six metastases to the brain and 11 meningiomas). 2908290 1988
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE In metastatic tumours, amplification of ERBB gene was detected in three metastatic tumours (9.4%), and all of them had allelic deletion of the LMYC gene. 2386738 1990
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE Suppression of spontaneous melanoma metastasis in scid mice with an antibody to the epidermal growth factor receptor. 2009538 1991
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE Those carcinomas with a high percentage of positive cells with all antibodies were more likely to have metastasized to nodes, be at an advanced stage, and be oestrogen receptor-negative/epidermal growth factor receptor-positive. 1684809 1991
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression phenotype BEFREE Ligand binding assays showed that EGFR expression in the highly metastasizing cell lines MV3 and BLM was at least 40 times higher than in the cell lines IF6, 530, M14, and Mel57, which do not or only sporadically metastasize after subcutaneous inoculation in nude mice. 1629628 1992
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE This suggests that EGFR gene amplification is not related to the local progression or metastasis of the SCC in the NC and PS. 1728365 1992
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE Aneuploid case was observed in 12 of observed 25 (48%) cases without lymph node metastasis, while it was observed in 16 of 17 cases (94.1%) with lymph node metastasis and there was significant association between DNA ploidy pattern and lymph node metastasis (P < 0.01) and most of the cases (17/20, 85%) were aneuploidy in Dukes C and D. The results above suggest that the expression of c-erbB-2 protein or EGFR was associated with distant metastasis, while on the other hand DNA ploidy pattern was correlated with lymph node metastasis. 7902886 1993
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE In situ hybridization of paraffin-embedded sections of primary human colon carcinoma and metastases from liver and lymph node revealed cell-specific staining with EGF-R antisense oligonucleotide probes that correlated directly with Northern blot and immunohistochemistry analyses. 8439966 1993
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression phenotype BEFREE Gross differences were not found between primary tumors and metastatic tumors with regard to the expression of c-erbB1, c-erbB2 and c-fos. 7913670 1994
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression phenotype BEFREE The receptor tyrosine kinase EGFR may be involved in late stage melanoma; the human exon with homology to Xmrk shows elevated transcription levels in 80% of human melanoma metastases. 7882274 1995
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE No consensus as to the involvement of the epidermal growth factor receptor (EGF-R) in colorectal carcinomas has yet been attained, although they are assumed to play a role in the metastasis to lymph nodes and recurrence of breast carcinoma and bladder carcinoma invasion. 7781795 1995
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE In a retrospective study the AGCN of the erbB genes and the time up to the appearance of metastases were subjected to life-table analysis in 128 women with primary breast cancer. 7607571 1995
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE Concomitant overexpression of the EGFR and erbB-2 genes in renal cell carcinoma (RCC) is correlated with dedifferentiation and metastasis. 8600053 1996
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE Up-regulated signaling from the epidermal growth factor receptor (EGFR) has been correlated with tumor invasion and metastasis in numerous human neoplasias. 9815625 1997
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression phenotype BEFREE EGFR expression of the cell lines was then correlated with their previously reported p53 expression, in vivo growth characteristics, and rate of metastases in athymic mice. 9042221 1997
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression phenotype BEFREE Here we show that overexpression of EGFR and c-erbB2 in cell lines increases cell migration, an important step in metastasis formation. 9541025 1998
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE Thus, 64% (11/17) and 52% (10/19) of metastatic and non-metastatic tumors respectively showed gains of the relative genomic content of erbB-1 and an association of erbB-1 with prostate cancer but not with metastasis. 9917515 1999
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE ErbB-2 amplification with a gene copy number > 1.6 in tumour tissue and erbB-1 deletion with a gene copy number < 0.4 in tumour-surrounding mucosa are of clinical relevance and indicate an early tumour recurrence or metastasis (p < 0.05). 10889928 2000
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE Two melanoma cell lines with different metastatic potential were used to study the association of EGFR gene fragments with the nuclear matrix and its role in cancer metastasis by polymerase chain reaction. 10628399 2000
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression phenotype BEFREE Our findings suggest that the clone with EGFR expression might selectively metastasize in some cutaneous SCCs. 11385224 2001
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 PosttranslationalModification phenotype BEFREE Our results suggest that overexpression of the EGFR gene might play an important role in metastasis of malignant melanoma. 11494118 2001
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE The expression of most genes involved in tumourigenesis (p53, Rb, cyclin D1, myc, bcl-2, EGFR, neu, and E-cadherin) was similar in primary tumours and metastases. 11439361 2001
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE The results suggest the combined detection of nm23, Cath-D and EGFR as predictive markers of distant metastasis in ANN breast cancer patients. 11920647 2002
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression phenotype BEFREE Expression of EGF-R and VEGF was not different between the metastatic and non-metastatic tumors. 12460468 2002
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE The oncogenic effects of EGFR include initiation of DNA synthesis, enhanced cell growth, invasion, and metastasis. 12017269 2002