Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE Gastric cancers frequently overexpress the epidermal growth factor receptor (EGFR), which has been implicated in pathological processes including tumor cell motility, invasion and metastasis. 29237412 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE Previous studies have demonstrated the association between EGFR mutations and distant metastasis. 29447182 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE Miliary metastases are associated with epidermal growth factor receptor mutations in non-small cell lung cancer: a population-based study. 28521651 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE Dysregulation of the epidermal growth factor receptor (EGFR) promotes cancer cell growth, invasion and metastasis. 28703807 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE The findings suggested that patients with ALK rearrangements are more likely to be young, have EGFR wild-type, and more likely to exhibit mucus secretion, solid tumor growth, lymph node metastasis and pleural metastasis. 26888425 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE Colorectal cancer is a multistep process affecting several signaling pathways including EGFR (epidermal growth factor receptor), a therapeutic target for metastatic disease. 28936923 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE Relationship between EGFR gene mutation and local metastasis of resectable lung adenocarcinoma. 28253871 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE Loss of protocadherin-17 (PCDH-17) promotes metastasis and invasion through hyperactivation of EGFR/MEK/ERK signaling pathway in hepatocellular carcinoma. 26386721 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression phenotype BEFREE In view of the findings that EGF/EGFR-mediated MMP-9 expression is closely related to invasion and metastasis of breast cancer. 27087131 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE Epidermal growth factor (EGF) and its receptor, EGFR, play roles in cancer metastasis. 26774845 2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE Regional therapy has shown promising results in patients with an oligo-metastasis after the occurrence of resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). 26496741 2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE Primary tumors co-injected with MSCs expressed higher phospho-epidermal growth factor receptor (p-EGFR) and promoted metastasis development after tumor resection, effects that were abrogated by treatment with the epidermal growth factor receptor (EGFR) inhibitor, erlotinib. 25887413 2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE Patients had advanced NSCLC, oncogenic EGFR mutations in the tumor, and no prior chemotherapy for metastatic disease and were treated with erlotinib or chemotherapy. 26181014 2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression phenotype BEFREE Moreover, the alteration of MMP-2, MMP-9, TGF-β and epidermal growth factor receptor (EGFR) expression, associated with the migration and metastasis potential of lung cancer cell lines, was identified by western blot analysis in transfected cells. 26151179 2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE Mitochondrial translocation of EGFR regulates mitochondria dynamics and promotes metastasis in NSCLC. 26497368 2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE Phase II/III data however, from non-EGFR mutation enriched populations, have demonstrated no benefit in progression free or overall survival with the addition of erlotinib to metastasis directed radiotherapy. 26967582 2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE We have recently shown that Nrdp1 inhibits phosphorylation of ErB3 in colorectal cancer (CRC) cells, to suppress epidermal growth factor receptor (EGFR) signaling-stimulated MMP7 activation for CRC metastasis. 25926384 2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE CX3CL1 increases invasiveness and metastasis by promoting epithelial-to-mesenchymal transition through the TACE/TGF-α/EGFR pathway in hypoxic androgen-independent prostate cancer cells. 26718770 2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE As a consequence, c-Src phosphorylated EGFR, promoting the invasion and metastasis of HCCs. 25958313 2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE Generally, substantial concordance was observed between primary and metastatic tumours in terms of EGFR, KRAS, BRAF, p16 and p53 mutations. 26338018 2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression phenotype BEFREE Our results showed that NCL expression in all 40 cases of ESCC tissues with metastasis was extensively located in the nucleus, cytoplasm and cell membrane (extra-nucleus), while NCL expression in all 20 cases of ESCC without metastasis was merely limited into the nucleus (intra-nucleus).The extra-nuclear NCL expression was positively correlated with the expression of EGFR, CXCR4 and Ki67 and serves as an independent prognostic factor for ESCC patients. 25631630 2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE Distant metastases were more frequently identified as the first recurrence site in EGFR-mutant patients than in wild-type patients (76% versus 40%, p = 0.001). 26743855 2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE The development of these newer drugs, with efficacy after resistance to first-line EGFR tyrosine kinase inhibitor, has led to exploration of these strategies in multiple disease settings: at resistance, in the first line, and in adjuvant treatment of those with completely resected early-stage disease who would otherwise die of recurrent/metastatic disease. 25979928 2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE These studies show, for the first time, a correlation between FABP5 and EGFR in enhancing TNBC metastasis through a novel mechanism. 25779666 2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE No significant differences were observed in the occurrence of EGFR gene mutations in primary tumors compared to metastases (7.9% vs. 11.2%; p=0.092), or in FFPE samples compared to cytological samples (8.9% vs. 8.1%; p=0.813). 25534657 2016