Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
0.400 Biomarker phenotype BEFREE It has been recently identified that the CXCR4/CXCL12 axis plays a pivotal role in breast cancer metastasis, especially in directing metastatic cancer cells to CXCL12-riched organs and tissues. 31698158 2020
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
0.400 Biomarker phenotype BEFREE Their modes of action include the antagonization of the chemokine CXCL12, which plays a central role in tumor development and metastasis. 31726164 2020
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
0.400 Biomarker phenotype BEFREE The CXCR4/CXCL12 axis plays a crucial role in cancer metastasis, and the blocking of the CXCR4/CXCL12 axis is an effective way of inhibiting cancer metastasis. 31603448 2019
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
0.400 Biomarker phenotype BEFREE CONCLUSIONS The expressions of serum CX3CL1, CXCL-12, and CCL20 are increased markedly in the patients, which may promote the occurrence, development and metastasis of esophageal cancer. 31385574 2019
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
0.400 Biomarker phenotype BEFREE SIGNIFICANCE: An anti-semaphorin-4D vascular targeting agent demonstrates antitumor and prosurvival effects but also unravels a novel promalignant effect involving macrophage-derived SDF1 that promotes tumor invasion and metastasis, both in animal models and patients.<b>Graphical Abstract:</b> http://cancerres.aacrjournals.org/content/canres/79/20/5328/F1.large.jpg.<i>See related commentary by Tamagnone and Franzolin, p. 5146</i>. 31239269 2019
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
0.400 AlteredExpression phenotype BEFREE We found that the CXCL12 receptor CXCR4 is highly expressed in both human primary tumors and metastases. 30700545 2019
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
0.400 Biomarker phenotype BEFREE Reduced expression of CXCL12 in the metastasising OMMs implies that the CXCR4/CXCL12 axis may be involved in OMM metastasis. 31019223 2019
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
0.400 Biomarker phenotype BEFREE The CXCL12-CXCR4 signaling axis plays an important role in tumor progression and metastasis, but also in treatment-induced recruitment of CXCR4-expressing cytotoxic immune cells. 31802362 2019
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
0.400 Biomarker phenotype BEFREE Therefore, CXCL12 might be associated with metastasis and poor prognosis in intrahepatic cholangiocarcinoma. 31361379 2019
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
0.400 Biomarker phenotype BEFREE The CXCR4/CXCL12 axis plays prominent roles in tumor metastasis and inflammation. 30981691 2019
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
0.400 AlteredExpression phenotype BEFREE Further study indicated that CXCL12 expression was positively correlated innate inflammation pathways such as NFκB and negatively correlated with metastasis, while EPHB3 had a reverse result. 30503499 2019
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
0.400 Biomarker phenotype BEFREE Cells transfected with shHOTAIR or miR-126 mimic were subjected to western blot to investigate the role of SDF-1/CXCR4 signaling in HOTAIR mediated proliferation and metastasis. 31517442 2019
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
0.400 Biomarker phenotype BEFREE CXCR4 and its cognate ligand CXCL12 has been linked to various pathways such as cancer metastasis, inflammation, HIV-1 proliferation, and auto-immune diseases. 30514601 2019
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
0.400 Biomarker phenotype BEFREE The data suggest that the MIF/CXCR7/AKT pathway drives CRPC growth and metastasis independent of the CXCL12/CXCR4 axis. 30224544 2019
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
0.400 Biomarker phenotype BEFREE The CXCR-4+CXCR-7+CXCL-12 marker (CXCR-4/7+CXCL-12 (α/b) signature) stratified patients into risk for metastasis (P= 0.0014; OR, 2.72) and OS (P= 0.0442; OR, 2.7); sensitivity: 86.67%, specificity: 97.06%. 31524146 2019
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
0.400 Biomarker phenotype BEFREE Activation of CXCL12/CXCR4 axis has been found to be associated with invasion and metastasis in many cancers. 30678736 2019
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
0.400 Biomarker phenotype BEFREE The CXCL12-CXCR4 signaling axis plays a key role in cancer metastasis and is a potential target for developing novel therapeutics against metastatic cancer. 31724498 2019
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
0.400 Biomarker phenotype BEFREE However, little is known about the potential downstream signals of the CXCL12/CXCR4 axis that contribute to ovarian cancer cell invasion and metastasis. 31445707 2019
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
0.400 Biomarker phenotype BEFREE OS differences were not statistically different between patients with CXCL12 positive or negative tumors for either localized or metastatic disease. 31412792 2019
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
0.400 Biomarker phenotype BEFREE It is documented that CXCR4 signaling supports tumor metastasis formation in tissues where CXCL12, its cognate ligand, is abundant. 30787324 2019
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
0.400 Biomarker phenotype BEFREE Role of CXCL12-CXCR4 axis in ovarian cancer metastasis and CXCL12-CXCR4 blockade with AMD3100 suppresses tumor cell migration and invasion in vitro. 30191987 2019
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
0.400 Biomarker phenotype BEFREE We focused on signaling by chemokine CXCL12, a hallmark molecule secreted by CAFs, and receptor CXCR4, a driver of tumor progression and metastasis in TNBC. 29416611 2018
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
0.400 Biomarker phenotype BEFREE Moreover, HCQ disturbed the CXCR4/CXCL12 axis which could induce invasion and metastasis of malignant melanoma in an autophagy-independent way. 30099017 2018
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
0.400 Biomarker phenotype BEFREE Our data suggest a mechanism whereby CAFs promote tumor cell migration and invasion through CXCL12 secretion to regulate the mDia2-directed cytoskeleton in breast tumor cells. 29596520 2018
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
0.400 Biomarker phenotype BEFREE We have previously demonstrated that the stromal cell‑derived factor (SDF‑1)/CXCR4 system is involved in the metastasis of head and neck cancer. 29749473 2018