Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 AlteredExpression disease BEFREE In conclusion, reduced levels of β-catenin, MYC, and WT1 are molecular markers for the efficacy of HDACi. 31561534 2019
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 Biomarker disease BEFREE Mutations were detected in previously described WT "hot spots" (e.g., WT1 and CTNNB1) as well as novel loci that may be unique to the Iraqi population. 30155617 2018
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 Biomarker disease BEFREE Wilm's tumor 1 (WT1) has been found to have opposing roles with β-catenin in podocyte biology. 28315733 2017
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 Biomarker disease CTD_human A Children's Oncology Group and TARGET initiative exploring the genetic landscape of Wilms tumor. 28825729 2017
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 Biomarker disease BEFREE We previously showed that coordinate activation of Ras and β-catenin accelerates the growth and metastatic progression of a murine WT model. 28188683 2017
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 AlteredExpression disease BEFREE PCA suppressed transcription activity of Wnt/β-catenin pathway in WT1-dependent manner. 29285297 2017
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 Biomarker disease BEFREE Our studies provide proof of the concept that the canonical Wnt/β-catenin pathway may be a novel therapeutic target in the management of WT. 28695795 2017
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 GeneticVariation disease BEFREE We also describe, for the first time, a small, constitutive partial gain of 3p22.1 comprising 2 exons of CTNNB1, a gene associated to WT. 26317783 2015
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 Biomarker disease BEFREE β-catenin, an important gene in the Wnt canonical pathway, was downregulated after WT1 RNAi. 25310451 2014
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 Biomarker disease BEFREE Other genes frequently altered somatically in subsets of WT are CTNNB1 and WTX; both genes influence the Wnt signalling pathway. 22461142 2013
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 Biomarker disease BEFREE At least three different pathways are involved in Wilms tumor; this review represents the outcome of the workshop discussion on the WNT/β-catenin pathway in Wilms tumorigenesis. 24258344 2013
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 AlteredExpression disease BEFREE Somatic mutations in exon 3 of CTNNB1, which encodes β-catenin, were initially observed in 15% of WT. 23117548 2013
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 Biomarker disease BEFREE Abnormalities of WT1, WTX and CTNNB1, and loss of IGF2 imprinting (LOI) were detected in 31.6%, 22.8%, 26.3%, and 21.1% of the 114 WTs, respectively. 22409817 2012
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 Biomarker disease BEFREE The 17.94 cell line contained a TP53 mutation, consistent with the anaplastic histology of the original tumor, but lacked mutations in WT1, WTX, or CTNNB1, which are the other genes involved in WT pathogenesis. 22749038 2012
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 AlteredExpression disease BEFREE Introduction of a stabilizing β-catenin mutation restricted to the kidney is sufficient to induce primitive renal epithelial tumors; however, when compounded with activation of K-RAS, the mice develop large, bilateral, metastatic, multifocal primitive renal epithelial tumors that have the histologic and staining characteristics of the epithelial component of human WT. 21983638 2011
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 Biomarker disease CTD_human GS expression was not observed in CTNNB1-mutated nephroblastoma. 21237236 2011
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 GeneticVariation disease BEFREE Genes identified as being mutated in Wilms' tumour include TP53, a classic tumour suppressor gene (TSG); CTNNB1 (encoding β-catenin), a classic oncogene; WTX, which accumulating data indicate is a TSG; and WT1, which is inactivated in some Wilms' tumours, similar to a TSG. 21248786 2011
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 Biomarker disease BEFREE One blastema-type nephroblastoma showed nuclear localisation of β-catenin in conjunction with LOH of the APC gene. 22081130 2011
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 GeneticVariation disease BEFREE GS expression was not observed in CTNNB1-mutated nephroblastoma. 21237236 2011
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 Biomarker disease BEFREE In contrast, FZD7-resistant WT in which no cell death was induced showed a different intra-cellular route of the Ab-FZD7 complex compared with sensitive tumors and accumulation of β-catenin. 21472018 2011
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 GeneticVariation disease BEFREE Wilms' tumor (WT), the most common pediatric renal malignancy, is associated with mutations in several well-characterized genes, most notably WT1, CTNNB1, WTX, and TP53. 20332316 2010
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 Biomarker disease BEFREE Based on characterization of both genomic and expression status of WT1 and CTNNB1 (beta-catenin) in a series of 60 Wilms tumor samples, combined with genome-wide expression profiling of these tumors, normal mature and fetal kidney controls, we show that WT1/beta-catenin expression was a better classifier than WT1/CTNNB1 mutations. 19530245 2009
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 GeneticVariation disease LHGDN Canonical WNT signalling determines lineage specificity in Wilms tumour. 19137020 2009
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 GeneticVariation disease BEFREE Clinical relevance of mutations in the Wilms tumor suppressor 1 gene WT1 and the cadherin-associated protein beta1 gene CTNNB1 for patients with Wilms tumors: results of long-term surveillance of 71 patients from International Society of Pediatric Oncology Study 9/Society for Pediatric Oncology. 18618575 2008
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 Biomarker disease BEFREE Cytoplasmic beta-catenin accumulation was demonstrated in two papillary carcinomas, one neuroblastoma-associated carcinoma, and two carcinomas arising from nephroblastoma. 17873895 2007