Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker disease BEFREE Several genetic loci have been shown to be associated with Wilms tumor formation, including WT1, WT2, FWT1, FWT2, CTNNB1, WTX, and TP53. 30671724 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 AlteredExpression disease BEFREE In this review, we summarize current knowledge about p53 pathway inactivation in childhood blastomas (specifically neuroblastoma, retinoblastoma and Wilms' tumor) through various upstream mechanisms. 30585860 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker disease BEFREE HnRNPL promotes Wilms tumor progression by regulating the p53 and Bcl2 pathways. 31213844 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker disease CTD_human A Children's Oncology Group and TARGET initiative exploring the genetic landscape of Wilms tumor. 28825729 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation disease BEFREE All DAWTs registered on National Wilms Tumor Study-5 (n = 118) with available samples were analyzed for TP53 mutations and copy loss. 27702824 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker disease BEFREE Wilms tumor gene 1 (WT1), TP53, RAS/BRAF and KIT aberrations in testicular germ cell tumors. 27085458 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation disease BEFREE We show that (i) in the choroid plexus carcinoma, the germline mutation was detected in a homozygous state due to copy-neutral LOH/uniparental disomy, (ii) in the secondary AML, a complex karyotype led to loss of the wild-type TP53 allele, (iii) in the Wilms tumor, the somatic mutation c.814G>A led to compound heterozygosity. 25787918 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation disease BEFREE To assess the impact of TP53 mutations and polymorphisms (PIN2, PIN3, and PEX4) on risk of development, age at diagnosis, and survival in WT, we analyzed 46 blood DNA samples and 31 fresh tumor DNA samples from 52 patients with WT. 24038938 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation disease BEFREE TP53 mutational status is a potential marker for risk stratification in Wilms tumour with diffuse anaplasia. 25313908 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation disease BEFREE Extensive studies have identified somatic mutations at several loci in Wilms' tumorigenesis, including WT1, catenin, Wilms' tumor gene on the X chromosome (WTX) and TP53. 24002362 2013
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 AlteredExpression disease BEFREE Relationships between survival and the following parameters were studied: tumor cell type, histologic grade, stage, p53 and WT1 expression, TP53 mutation, and presence of associated endometriosis. 23282975 2013
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation disease BEFREE Wilms tumor (WT) with diffuse anaplasia has an unfavorable prognosis and is often (>70%) associated with mutations in the TP53 gene. 23387809 2013
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation disease BEFREE In Wilms tumor (WT), mutations in the gene encoding p53, TP53, are correlated with anaplasia; however TP53 variants have not been studied in favorable histology (FH) WTs. 22052810 2012
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker disease BEFREE Somatic defects at five loci, WT1, CTNNB1, WTX, TP53 and the imprinted 11p15 region, are implicated in Wilms tumor, the commonest childhood kidney cancer. 22470196 2012
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 AlteredExpression disease BEFREE The overexpression of p53 in 44 specimens of children (26 boys and 18 girls) with Wilms tumor (median age, 36 months; range, 4 to 96 months) was assessed in Mofid Children's Hospital, Tehran, Iran. 21525573 2011
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation disease BEFREE Genes identified as being mutated in Wilms' tumour include TP53, a classic tumour suppressor gene (TSG); CTNNB1 (encoding β-catenin), a classic oncogene; WTX, which accumulating data indicate is a TSG; and WT1, which is inactivated in some Wilms' tumours, similar to a TSG. 21248786 2011
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker disease BEFREE Although WT1 and p53 positive glial cells were found in 17% and 63% of cases respectively, all samples were negative for mIDH1R132H. 20661018 2010
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation disease BEFREE Wilms' tumor (WT), the most common pediatric renal malignancy, is associated with mutations in several well-characterized genes, most notably WT1, CTNNB1, WTX, and TP53. 20332316 2010
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 AlteredExpression disease BEFREE The authors screened the GBM samples for p53 mutation by using PCR and single-stranded conformational polymorphism analysis, and they demonstrated an association between WT1 expression and p53 status. 17886559 2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker disease BEFREE WT1 siRNA increased the radiosensitivity of two human glioma cell lines independently of p53. 17206472 2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker disease BEFREE Wilms tumors are a heterogeneous class of tumors in which Wilms tumor suppressor-1 (WT1) and the p53 tumor suppressor may be variously inactivated by mutation, reduced in expression, or even overexpressed in the wild-type state. 15155752 2004
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 AlteredExpression disease BEFREE Wilms Tumor Gene (WT1) and p53 expression in endometrial carcinomas: a study of 130 cases using a tissue microarray. 15297187 2004
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation disease BEFREE Mutation of p53 has been implicated in progression of classical Wilms tumor (WT) into the anaplastic variant (AWT), drug resistance, and poor prognosis. 12007018 2002
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation disease BEFREE A high prevalence of p53 gene mutation and protein expression has been found in the anaplastic variant of Wilms' tumor (WT), known to be associated with poor outcome. 12065773 2002
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 AlteredExpression disease BEFREE The goal of this study was to obtain a better understanding of the role of p53 expression in WT. 11115550 2001