Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.800 Biomarker disease BEFREE Cells expressed various tumor markers of mesothelioma, such as calretinin, podoplanin, and Wilms tumor 1 (WT-1). 31583526 2020
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.800 Biomarker disease BEFREE Six eligible PDA patients underwent multimodal therapy comprising dendritic cells (DCs) pulsed with Wilms' tumor 1 (WT1) peptide (DC/WT1-I) restricted by the human leukocyte antigen (HLA) class I (A*24:02 or A*02:06) allele, chemotherapy, radiation, and/or surgery. 30230959 2019
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.800 GeneticVariation disease BEFREE Our previous study of congenital aniridia patients revealed a noticeable number of aniridia patients with WAGR-region deletions but without Wilms' tumor in their medical history. 31304537 2019
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.800 Biomarker disease BEFREE The Wilms' tumour factor-1 (WT1) gene is involved in early gonadal development in both sexes. 30294972 2019
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.800 AlteredExpression disease BEFREE Prolonged low levels of a granulocyte-related systemic inflammatory response after the early period of therapy and low cytoplasmic WT1 expression in PDA cells may be markers predictive of OS in PDA patients receiving WT1-targeting immunochemotherapy. 31216557 2019
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.800 Biomarker disease BEFREE Wilms tumor 1 (WT1) and preferentially expressed antigen in melanoma (PRAME) are promising immunogenic antigen candidates for immunotherapy, and their clinical effects on patients with MDS with thrombocytopenia are still not well understood. 31714962 2019
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.800 Biomarker disease BEFREE The Antitumor Activity of TCR-Mimic Antibody-Drug Conjugates (TCRm-ADCs) Targeting the Intracellular Wilms Tumor 1 (WT1) Oncoprotein. 31408937 2019
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.800 Biomarker disease BEFREE For the clinical development, we produced the B440 pharmaceutical formulation, which is lyophilized powder of inactivated <i>B. longum</i> 440 displaying the partially modified human WT1 protein.We confirmed that <i>B. longum</i> 440 could induce cellular immunity specific to multiple WT1 epitopes. 30824610 2019
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.800 Biomarker disease BEFREE Investigation of Insulin-Like Growth Factor-1 (IGF-1), P53, and Wilms' Tumor 1 (WT1) Expression Levels in the Colon Polyp Subtypes in Colon Cancer. 31341157 2019
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.800 GeneticVariation disease BEFREE This tumor was found to lack 5'-regional expression of the WT1 gene, as well as immunoreactivity with the N-WT1 antibody. 31103034 2019
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.800 Biomarker disease BEFREE Immunohistochemistry showed that the tumor cells were positive for CD10, estrogen receptor (ER), progesterone receptor (PR), Wilms tumor-1 (WT-1) and smooth muscle actin (SMA). 31010432 2019
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.800 GeneticVariation disease BEFREE Among the multilayered SECs, the superficial/luminal layer showed mucin 4 (MUC4), cytokeratin 5/6 (CK5/6), and CK7 expression in 5 cases (100%); MUC1, carcinoembryonic antigen (CEA), CA19-9, and thrombomodulin expression in 4 cases (80%); Wilms' tumor-1 (WT-1) and Hector Battifora mesothelial-1 (HBME-1) expression in 2 cases (40%), but it did not express p63 or D2-40. 31132652 2019
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.800 AlteredExpression disease BEFREE Evidence that downregulation of Wilms' tumor 1 (WT1) is involved in cortical stromal cell differentiation into theca cells in adult bovine ovaries. 31490589 2019
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.800 AlteredExpression disease BEFREE Retinoic acid-dependent and -independent hallmark genes of GATA6<sup>+</sup> macrophages were induced by mesothelial and fibroblastic stromal cells that express the transcription factor Wilms' Tumor 1 (WT1), which drives the expression of two rate-limiting enzymes in retinol metabolism. 31231034 2019
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.800 AlteredExpression disease BEFREE Few reports suggested a prognostic impact of Wilms'Tumor-1 (WT1)-mRNA overexpression in MDS, but translation into clinical routine was hampered by limited patients numbers, differing sample sources, non-standardized methods/cut-offs. 31719523 2019
Entrez Id: 2719
Gene Symbol: GPC3
GPC3
0.800 AlteredExpression disease BEFREE Contrarily, GPC3 is specifically expressed in hepatocellular carcinoma (HCC), ovarian clear cell carcinoma, melanoma, squamous cell carcinoma of the lung, hepatoblastoma, nephroblastoma (Wilms tumor), yolk sac tumor, and some pediatric cancers. 31024850 2019
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.800 Biomarker disease BEFREE Wilms tumor 1 (WT1), Zonula occludens-1 (ZO-1), AMP activated protein kinase (AMPK), and NADPH oxidase-4 (NOX-4) expression were evaluated by immunohistochemistry and Western blot. 30820023 2019
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.800 AlteredExpression disease BEFREE The expression levels of miR-361-5p and Wilms' tumor-1 (WT1) were detected by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR) assay. 31696469 2019
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.800 Biomarker disease BEFREE We expect that the procedure including IL-21 would improve the production rate of hTERT- and Wilms tumor 1 (WT1)-specific CD8<sup>+</sup> T cells for clinical trials. 30760061 2019
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.800 Biomarker disease BEFREE A phase I clinical study of a cocktail vaccine of Wilms' tumor 1 (WT1) HLA class I and II peptides for recurrent malignant glioma. 30430205 2019
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.800 Biomarker disease BEFREE We investigated pain sensitivity in humans with WAGR (Wilms tumor, aniridia, genitourinary anomaly, and range of intellectual disabilities) syndrome, who have variably sized heterozygous deletion of the 11p13 region. 30855519 2019
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.800 Biomarker disease BEFREE Gata2 is identified as a target of AR, and β1-integrin is a target of Wilms' tumor 1 (WT1) in Sertoli cells. 31142324 2019
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.800 Biomarker disease BEFREE The results indicated that PCE caused ultrastructural abnormalities on podocyte, and inhibited the expression of podocyte marker genes such as Nephrin, Wilms tumor 1 (WT1), the histone 3 lysine 9 acetylation (H3K9ac) level in the Kruppel-like factor 4 (KLF4) promoter and its expression in the male offspring from GD20 to PW28. 31306741 2019
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.800 Biomarker disease BEFREE Here, we utilize the Wilms Tumor-1 (Wt1)-Cre to delete Mrtfs or Srf in the epicardium, which reduced the number of EPDCs in the adult cardiac interstitium. 30771308 2019
Entrez Id: 2719
Gene Symbol: GPC3
GPC3
0.800 Biomarker disease BEFREE Loss of function mutations in <i>GPC3</i> lead to Simpson-Golabi-Behmel Syndrome, an X-linked overgrowth condition with a predisposition to GPC3-expressing cancers including hepatoblastoma and Wilms tumor. 30873384 2019