Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 Biomarker group BEFREE BDNF has also been implicated in a plethora of neurological disorders. 31532010 2020
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 Biomarker group BEFREE Therefore, inhibition of SHIP2 appears to be valuable therapeutic strategy against neurological disorders associated with insufficient BDNF functions. 30753865 2019
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 AlteredExpression group BEFREE Finally, high throughput sequencing data from different brain regions and neurological disorders were analyzed to measure correlation of candidate miRNAs with BDNF level in experimental studies. 31751881 2019
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 AlteredExpression group BEFREE In conclusion, we proved the neurogenic potential of several hb-HDACis, alongside their ability to enhance <i>BDNF</i> expression, which by modulating the neurogenesis and/or compensating for neuronal loss, could be propitious for treatment of neurological disorders. 30841499 2019
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 AlteredExpression group BEFREE The significant positive impact of curcumin supplementation on BDNF levels indicates its potential use for neurological disorders that are associated with low BDNF levels. 31279955 2019
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 Biomarker group BEFREE When compared with GB treatment, GK treatment maintained high levels of phosphoinositide 3‑kinase/phosphorylated‑protein kinase B expression, and induced a marked upregulation of Wnt family member 1 and brain derived neurotrophic factor, indicating that GK, as a natural plant compound, may have more attractive prospects for clinical application in the treatment of neurological disorders than GB. 30221704 2018
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 AlteredExpression group BEFREE Accumulating evidence suggests that a decrease in brain-derived neurotrophic factor (BDNF) level induces a variety of psychiatric and neurological disorders. 29540150 2018
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 Biomarker group BEFREE The presence of neurotrophin receptors in the HUCB CD45<sup>+</sup> pan-hematopoietic subpopulation may explain the neuroprotective effect of cord blood in therapy of a variety of neurological disorders. 29274773 2018
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 Biomarker group BEFREE <i>α</i>-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor (AMPA-R) potentiators with brain-derived neurotrophic factor (BDNF)-induction potential could be promising as therapeutic drugs for neuropsychiatric and neurologic disorders. 29298820 2018
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 Biomarker group BEFREE Novel BDNF-focused interventions are being developed for obesity, diabetes and neurological disorders. 29217485 2018
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 AlteredExpression group BEFREE Multiple BDNF transcripts have distinct functional properties and epigenetic modulation of BDNF gene transcription is implicated in the neurological disorders. 29305263 2018
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 Biomarker group BEFREE Brain-derived neurotrophic factor (<i>Bdnf</i>) has been implicated in several neurological disorders including Rett syndrome (RTT), an X-linked neurodevelopmental disorder caused by loss-of-function mutations in the transcriptional modulator methyl-CpG-binding protein 2 <i>(MECP2)</i>. 28751857 2017
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 Biomarker group BEFREE The Effect of Aerobic Exercise on Brain-Derived Neurotrophic Factor in People with Neurological Disorders: A Systematic Review and Meta-Analysis. 29057125 2017
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 PosttranslationalModification group BEFREE Thus, understanding the epigenetic regulation at the BDNF promoters will shed light on future therapies for neurological disorders. 28272318 2017
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 Biomarker group BEFREE Bone marrow-derived mesenchymal stem cells (BMMSCs) may provide a potential cell-based therapy against neurologic disorders through induction of brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF). 28492549 2017
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 Biomarker group BEFREE Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family critical for neuronal cell survival and differentiation, with therapeutic potential for the treatment of neurological disorders and spinal cord injuries. 28466111 2017
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 Biomarker group BEFREE Brain-derived neurotrophic factor (BDNF) exerts substantial protective effects for neurological disorders. 28243312 2017
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 AlteredExpression group BEFREE Serum BDNF levels were analyzed by ELISA kit in 378 subjects: 134 Alzheimer's disease (AD) patients, 115 amnestic mild cognitive impairment (MCI) patients, and 129 controls divided into two groups: neurodegenerative control group (ND), consisting of 49 Parkinson's disease patients without any cognitive complaints, and cognitively normal control group (CN), consisting of 80 subjects without any neurological disorders. 28341039 2017
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 Biomarker group BEFREE Neuregulin 3 (NRG3), a brain-enriched neurotrophin, undergoes alternative splicing and is implicated in several neurological disorders with developmental origins. 27771971 2017
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 GeneticVariation group BEFREE An optimised liposomal formulation [DPPC/P-lyso-PC/DSPE-PEG2000 90/10/4 (mol/mol) (LTSL)] was chosen for further application in encapsulating therapeutic proteins, such as lysozyme and the brain-derived neurotrophic factor (BDNF), which are recognized as drug carriers and potential therapeutic agents for kidney diseases and neurological disorders. 28377318 2017
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 GeneticVariation group BEFREE Various studies suggested that brain-derived neurotrophic factor (BDNF) gene polymorphisms contributed to the development of many neurological disorders. 26000807 2016
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 Biomarker group BEFREE The mean value for urinary extracellular neurotrophin receptor p75 from 28 amyotrophic lateral sclerosis patients measured by ELISA was 7.9±0.5 ng/mg creatinine and this was significantly higher (p<0.001) than 12 controls (2.6±0.2 ng/mg creatinine) and 19 patients with other neurological disease (Parkinson's disease and Multiple Sclerosis; 4.1±0.2 ng/mg creatinine). 24475283 2014
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 AlteredExpression group BEFREE Accumulating evidence suggests that alterations in BDNF expression levels underlie a variety of psychiatric and neurological disorders. 25223903 2014
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 Biomarker group BEFREE Brain-derived neurotrophic factor (BDNF) has been implicated in the pathophysiology of psychiatric and neurological disorders and in the mechanisms of antidepressant pharmacotherapy. 23253771 2013
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 Biomarker group BEFREE Decreased expression of neuronal genes such as brain-derived neurotrophic factor (BDNF) is associated with several neurological disorders. 23712629 2013