Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2348
Gene Symbol: FOLR1
FOLR1
0.340 GeneticVariation group BEFREE We suggest that T-DMRs participate in the regulation of expression of the FOLR1 and RFC1 genes, that the RFC1 80G > A polymorphism exerts a gene-nutrition interaction on DNA methylation in the RFC1 gene, and that this interaction appears to be most prominent in NTD-affected births and in subjects with high tHcy concentrations. 23417011 2013
Entrez Id: 2348
Gene Symbol: FOLR1
FOLR1
0.340 Biomarker group BEFREE Folate binding protein 1 (Folr1) knockout mice with low maternal folate concentrations have been shown to be excellent animal models for human folate-responsive neural tube defects (NTDs). 16256389 2006
Entrez Id: 2348
Gene Symbol: FOLR1
FOLR1
0.340 Biomarker group CTD_human Role of Folbp1 in the regional regulation of apoptosis and cell proliferation in the developing neural tube and craniofacies. 15800851 2005
Entrez Id: 2348
Gene Symbol: FOLR1
FOLR1
0.340 Biomarker group BEFREE Using a Midwestern NTD population consisting of probands, parents, and siblings from Iowa, Minnesota, and Nebraska, we analyzed a range of candidate genes, including 5,10-methylenetetrahydrofolate reductase (MTHFR), folate receptors-alpha (FOLR1; hereafter abbreviated "FR-alpha") and -beta (FOLR2; hereafter, "FR-beta"), methionine synthase (hereinafter, "MS"), T, the human homolog of the murine Brachyury gene, and the paired-box homeotic gene 3 (PAX3), for association with NTDs. 10332959 1999
Entrez Id: 2348
Gene Symbol: FOLR1
FOLR1
0.340 GeneticVariation group BEFREE It is unlikely that the beneficial effects of maternal folate supplementation in preventing NTDs acts through a mechanism involving pharmacological correction of a variant form of folate receptor alpha. 9545095 1998