Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2348
Gene Symbol: FOLR1
FOLR1
0.400 AlteredExpression group BEFREE Furthermore, doubly heterozygous mouse embryos lacking one copy each of Shroom3 and Folr1 exhibit a low rate of neural tube defects and also have lower levels of activated myosin light chain and MLCK. 30670450 2019
Entrez Id: 2348
Gene Symbol: FOLR1
FOLR1
0.400 AlteredExpression group BEFREE In NTDs, there was an adaptive up-regulation of folate transporters mainly reduced folate carrier (p < 0.001) and folate receptor alpha (p < 0.001). 30941645 2019
Entrez Id: 2348
Gene Symbol: FOLR1
FOLR1
0.400 Biomarker group BEFREE Folates and FOLR1 are established modifiers of risk for neural tube defects, and binding data indicates DTG is a partial antagonist of FOLR1. 31259764 2019
Entrez Id: 2348
Gene Symbol: FOLR1
FOLR1
0.400 Biomarker group BEFREE Several experimental studies in mice and human epidemiological and genetics studies have suggested that folate receptor abnormalities are involved in a portion of human NTDs, although the solo defect of FOLR1 did not cause NTD. 28244241 2017
Entrez Id: 2348
Gene Symbol: FOLR1
FOLR1
0.400 Biomarker group BEFREE Folr1 knockdown in neural plate cells only is necessary and sufficient to induce NTDs. 28255006 2017
Entrez Id: 2348
Gene Symbol: FOLR1
FOLR1
0.400 GeneticVariation group BEFREE We suggest that T-DMRs participate in the regulation of expression of the FOLR1 and RFC1 genes, that the RFC1 80G > A polymorphism exerts a gene-nutrition interaction on DNA methylation in the RFC1 gene, and that this interaction appears to be most prominent in NTD-affected births and in subjects with high tHcy concentrations. 23417011 2013
Entrez Id: 2348
Gene Symbol: FOLR1
FOLR1
0.400 Biomarker group BEFREE Folate binding protein 1 (Folr1) knockout mice with low maternal folate concentrations have been shown to be excellent animal models for human folate-responsive neural tube defects (NTDs). 16256389 2006
Entrez Id: 2348
Gene Symbol: FOLR1
FOLR1
0.400 Biomarker group CTD_human Role of Folbp1 in the regional regulation of apoptosis and cell proliferation in the developing neural tube and craniofacies. 15800851 2005
Entrez Id: 2348
Gene Symbol: FOLR1
FOLR1
0.400 GeneticVariation group BEFREE This study, though preliminary, provides the first genetic association between molecular variations of the FRalpha gene and NTDs and suggests that this gene can act as a risk factor for human NTD. 11102926 2000
Entrez Id: 2348
Gene Symbol: FOLR1
FOLR1
0.400 Biomarker group BEFREE Using a Midwestern NTD population consisting of probands, parents, and siblings from Iowa, Minnesota, and Nebraska, we analyzed a range of candidate genes, including 5,10-methylenetetrahydrofolate reductase (MTHFR), folate receptors-alpha (FOLR1; hereafter abbreviated "FR-alpha") and -beta (FOLR2; hereafter, "FR-beta"), methionine synthase (hereinafter, "MS"), T, the human homolog of the murine Brachyury gene, and the paired-box homeotic gene 3 (PAX3), for association with NTDs. 10332959 1999
Entrez Id: 2348
Gene Symbol: FOLR1
FOLR1
0.400 GeneticVariation group BEFREE It is unlikely that the beneficial effects of maternal folate supplementation in preventing NTDs acts through a mechanism involving pharmacological correction of a variant form of folate receptor alpha. 9545095 1998