Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6790
Gene Symbol: AURKA
AURKA
0.400 AlteredExpression disease BEFREE The tumor-suppressive miR-186 that is downregulated in neuroblastoma and in TGFβ-treated NK cells represses oncogenic proteins in neuroblastoma (MYCN and AURKA) and components of the TGFβ pathway. 30936073 2019
Entrez Id: 6790
Gene Symbol: AURKA
AURKA
0.400 Biomarker disease BEFREE Preclinical and early-phase clinical studies of BRD4 and AURKA inhibitors, however, show limited efficacy against neuroblastoma when used alone. 30153557 2018
Entrez Id: 6790
Gene Symbol: AURKA
AURKA
0.400 AlteredExpression disease BEFREE In line with the prediction of GWL/MASTL enhancing AURKA, elevated expression of GWL/MASTL was associated with NB risk factors and poor survival of patients. 26616283 2016
Entrez Id: 6790
Gene Symbol: AURKA
AURKA
0.400 Biomarker disease BEFREE A LIN28B-RAN-AURKA Signaling Network Promotes Neuroblastoma Tumorigenesis. 26481147 2015
Entrez Id: 6790
Gene Symbol: AURKA
AURKA
0.400 Biomarker disease BEFREE Here, we studied the effects of the pan-aurora kinase inhibitor tozasertib (VX680, MK-0457) and the aurora kinase inhibitor alisertib (MLN8237) that shows some specificity for aurora kinase A over aurora kinase B in a panel of neuroblastoma cell lines with acquired drug resistance. 25268132 2014
Entrez Id: 6790
Gene Symbol: AURKA
AURKA
0.400 Biomarker disease BEFREE Therefore, we sought to determine whether inhibition of AURKA modulates neuroblastoma angiogenesis. 24439602 2014
Entrez Id: 6790
Gene Symbol: AURKA
AURKA
0.400 Biomarker disease BEFREE PTPRD has a tumor suppressor function in neuroblastoma through AURKA dephosphorylation and destabilization and a downstream destabilization of MYCN protein, representing a novel mechanism for the function of PTPRD in neuroblastoma. 22305495 2012
Entrez Id: 6790
Gene Symbol: AURKA
AURKA
0.400 Biomarker disease BEFREE We aimed to investigate AURKA and MYCN gene rearrangements and the chromosomal aberrations (CAs) to determine the prognosis of neuroblastoma. 23317189 2012
Entrez Id: 6790
Gene Symbol: AURKA
AURKA
0.400 Biomarker disease CTD_human Development of treatment strategies for advanced neuroblastoma. 22588779 2012
Entrez Id: 6790
Gene Symbol: AURKA
AURKA
0.400 GeneticVariation disease BEFREE Although it is not yet known if this interaction contributes to neuroblastoma disease pathogenesis, it is intriguing that the interaction occurs at the promoter regions of several genes important for the development of neuroblastoma, including ALK, AURKA and BDNF. 21731748 2011
Entrez Id: 6790
Gene Symbol: AURKA
AURKA
0.400 Biomarker disease BEFREE In a shRNA screen of genes that are highly expressed in MYCN-amplified tumors, we have identified AURKA as a gene that is required for the growth of MYCN-amplified neuroblastoma cells but largely dispensable for cells lacking amplified MYCN. 19111882 2009
Entrez Id: 6790
Gene Symbol: AURKA
AURKA
0.400 Biomarker disease BEFREE STK15 amplification has been previously detected in breast tumour cell lines and in colon tumours; here, we report its amplification in approximately 12% of primary breast tumours, as well as in breast, ovarian, colon, prostate, neuroblastoma and cervical cancer cell lines. 9771714 1998