Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
1.000 GeneticVariation disease BEFREE Six other SNPs, rs2815752 (NEGR1), rs10938397 (GNPDA2), rs10838738 (MTCH2), rs7498665 (SH2B1), rs17782313 (MC4R) and rs11084753 (KCTD15), were not associated with obesity (P>0.05). 22083549 2012
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
1.000 GeneticVariation disease BEFREE Melanocortin-4 receptor polymorphism rs17782313: association with obesity and eating in the absence of hunger in Chilean children. 24139164 2014
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE PPARγ Pro12Ala interacts with fat intake for obesity and weight loss in a behavioural treatment based on the Mediterranean diet. 22102511 2011
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
1.000 GeneticVariation disease BEFREE Most of these obesity disorders exhibit a distinct phenotype with varying degrees of hypothalamic and pituitary dysfunction and a recessive inheritance, whereas MC4-R mutation has a nonsyndromic phenotype with dominant inheritance. 10508193 1999
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
1.000 GeneticVariation disease BEFREE Metabolic and hormonal consequencies of the "obesity risk" MC4R variant (rs12970134) in Czech women. 26680479 2015
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
1.000 GeneticVariation disease BEFREE MC4R mutations are not a common cause of obesity in Norway and screening of obese patients does not appear to be warranted. 19301229 2009
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
1.000 GeneticVariation disease BEFREE Recently, Pomc knockout mice were generated and shown to develop hyperphagia and obesity with a time-course and severity comparable to MC4-R knockout mice, whereas daily administration of a stable alpha-melanocyte stimulating hormone analogue reversed this effect. 10885325 2000
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
1.000 GeneticVariation disease BEFREE As the MC4R locus explains only 0.28% of the BMI and 0.14% of the WC phenotypic variance in the Scottish population, most of the genetic contribution to obesity remains to be identified. 19050674 2009
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
1.000 GeneticVariation disease BEFREE In conclusion, this study confirmed and extended the previous findings, suggesting the MC4R V103I polymorphism is negatively associated with human obesity. 19696756 2010
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
1.000 GeneticVariation disease UNIPROT In conclusion, a pathogenic MC4R mutation was found among subjects with severe early-onset obesity but not among morbidly obese adults. 14764818 2004
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE We further show that in the context of diet-induced obesity PPARγ-K107R-mutant mice have enhanced insulin sensitivity without the corresponding increase in adiposity that typically accompanies PPARγ activation by TZDs. 30420515 2018
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
1.000 GeneticVariation disease BEFREE Heterozygous mutations in melanocortin-4 receptor (MC4R) are the most frequent genetic cause of obesity. 20957447 2011
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE The fat mass and obesity-associated gene (FTO) rs9939609 and peroxisome proliferator-activated receptor gamma 2 gene (PPARG2) rs1801282 polymorphisms are type 2 diabetes mellitus susceptibility gene variants associated with obesity. 24969838 2014
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease UNIPROT Obesity associated with a mutation in a genetic regulator of adipocyte differentiation. 9753710 1998
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
1.000 GeneticVariation disease BEFREE In our study, we addressed the hypothesis that a G-->A substitution at codon 103 (Val-103Ile) of the MC4R gene influences abdominal obesity, insulin, glucose, and lipid metabolism as well as circulating hormones, including salivary cortisol. 11692184 2001
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
1.000 GeneticVariation disease BEFREE These pharmacological data provide a basis to estimate the quantitative effect of MC4R mutations for the development of obesity. 12690102 2003
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
1.000 GeneticVariation disease BEFREE We conclude that rare heterozygous MC4R mutations contribute to the onset of obesity only in a few cases in the Slovak population. 26244670 2016
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
1.000 GeneticVariation disease BEFREE The fat mass and obesity (FTO) and melanocortin-4 receptor (MC4R) genes have been consistently associated with the risk for obesity, but few studies have examined the association of the obesity risk alleles with gestational outcomes. 27377581 2017
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
1.000 GeneticVariation disease BEFREE We aimed to determine the prevalence of melanocortin-4 receptor (MC4R) variants in a large German cohort of children with obesity in a pediatric outpatient clinic and to ascertain whether there is a specific phenotype associated with loss-of-function variants as previously reported. 27654141 2017
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE Furthermore, the P12A PPARgamma polymorphism was not associated with obesity or WHR in the control population; it did not interact with energy intake or energy expenditure to alter risk of obesity or large WHR. 15860437 2005
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
1.000 GeneticVariation disease BEFREE Female mice heterozygous for Mc4r fed an obesogenic or a control diet for 5 weeks were mated with heterozygous males, with the same diet continued throughout pregnancy and lactation, generating four offspring groups: control wild type (C_wt), control knockout (C_KO), obese wild type (Ob_wt), and obese knockout (Ob_KO). 28930194 2017
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
1.000 GeneticVariation disease BEFREE Downstream variants of the melanocortin-4 receptor (MC4R) gene have been associated with obesity in various populations. 22310352 2013
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
1.000 GeneticVariation disease BEFREE Melanocortin-4 receptor gene (MC4R) variants are associated with obesity and binge eating disorder (BED), whereas the more prevalent proopiomelanocortin (POMC) and leptin receptor gene (LEPR) mutations are rarely associated with obesity or BED. 15585384 2004
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
1.000 GeneticVariation disease BEFREE Individuals with mutations in MC4R gene have lower blood pressure (BP), independently of obesity. 23849767 2013
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
1.000 GeneticVariation disease BEFREE We focused on physical activity as an environmental risk factor, and on the GWA identified obesity variants in FTO (rs9939609) and near MC4R (rs17782313) as genetic risk factors. 18682847 2008