Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2147
Gene Symbol: F2
F2
0.540 GeneticVariation disease BEFREE To identify inherited factors: Protein C (PC), protein S (PS), antithrombin (AT), plasminogen (Plg), the activated PC resistance (APCR), prothrombin (PT) mutation G20210 A (PTG20210 A) and methylenetetrahydrofolate reductase C677 T polymorphism (MTHFR C677 T), as well as acquired-risk factors such as: diabetes mellitus, surgeries, smoking, obesity, hypertension, trauma, alcoholism, family history; and their association, in Mexican patients with diagnostic of thrombophilia. 26315791 2015
Entrez Id: 2147
Gene Symbol: F2
F2
0.540 Biomarker disease RGD Shortened blood coagulation times in genetically obese rats and diet-induced obese mice. 23628972 2013
Entrez Id: 2147
Gene Symbol: F2
F2
0.540 Biomarker disease CTD_human Therapeutic administration of the direct thrombin inhibitor argatroban reduces hepatic inflammation in mice with established fatty liver disease. 22841818 2012
Entrez Id: 2147
Gene Symbol: F2
F2
0.540 GeneticVariation disease BEFREE Common genetic polymorphisms in European-Ancestry populations, such as factor V Leiden and prothrombin G20210A, and environmental risk factors, such as obesity, may account for some of the increased risk in European populations, and high factor VIII, high von Willebrand factor and low protein C levels and increased prevalence of obesity may explain some of the increased risk in African-Americans. 21797965 2011
Entrez Id: 2147
Gene Symbol: F2
F2
0.540 GeneticVariation disease BEFREE Samples for the analysis of factor V Leiden (FVL), prothrombin gene variant (PGV) G20210A and methylenetetrahydrofolate reductase (MTHFR) were available in an additional 30 patients, that is 81 patients in all.Meta-analysis was performed.Of the 51 patients 40 were obese. 20400894 2010
Entrez Id: 2147
Gene Symbol: F2
F2
0.540 Biomarker disease BEFREE Relative to non-carriers of normal BMI, the joint effect of factor V Leiden and obesity led to a 7.9-fold increased risk (OR(adj) 7.86, 95% CI 4.70-13.15); for prothrombin 20210A this was a 6.6-fold increased risk (OR(adj) 6.58, 95% CI 2.31-18.69). 17897305 2007