Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
0.900 GeneticVariation disease BEFREE MC4R was sequenced in 47 consecutive morbidly obese children and adolescents (28 girls and 19 boys, aged 1-18 years) who presented during a one-year period. 28218067 2018
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.900 Biomarker disease BEFREE DBZ is a putative PPARγ agonist that prevents high fat diet-induced obesity, insulin resistance and gut dysbiosis. 28736228 2018
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
0.900 AlteredExpression disease BEFREE Correlations of MC4R and MSH2 expression with obesity in colon cancer patients. 28537674 2018
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
0.900 Biomarker disease BEFREE Rs12970134 near MC4R is associated with appetite and beverage intake in overweight and obese children: A family-based association study in Chinese population. 28520814 2017
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.900 Biomarker disease BEFREE Oleic acid activates MMPs up-regulation through SIRT1/PPAR-γ inhibition: a probable linkage between obesity and coronary arterial disease. 27072559 2017
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
0.900 GeneticVariation disease BEFREE Analysis of MC4R rs17782313, POMC rs1042571, APOE-Hha1 and AGRP rs3412352 genetic variants with susceptibility to obesity risk in North Indians. 26226973 2017
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
0.900 Biomarker disease BEFREE Assessing gene-environment interaction effects of FTO, MC4R and lifestyle factors on obesity using an extreme phenotype sampling design: Results from the HUNT study. 28384342 2017
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.900 Biomarker disease CTD_human Finally, human subcutaneous adipose tissues isolated from obese individuals exhibited reduced expression of APCDD1, C/EBPα, and PPARγ compared with those from non-obese subjects. 28242765 2017
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.900 GeneticVariation disease BEFREE The measured parameters for mothers and their newborns were risk percentage for child obesity, anthropometric characteristics (mid-upper arm circumference [MUAC], tricipital skinfold thickness [TST] of mother and newborn), genetic polymorphisms (human peroxisome proliferator-activated receptor γ [PPARγ2] 34 C > G and transforming growth factor-beta 1 [TGF-β1] 869 T > C gene polymorphisms in both mothers and newborns), and mother's bioimpedance characteristics (fat mass [FM] %).The obesity risk score according to standard predictable Northern Finland Birth Cohort equation was in our study 4.07%. 27442659 2017
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.900 Biomarker disease BEFREE New PPARγ partial agonist improves obesity-induced metabolic alterations and atherosclerosis in LDLr(-/-) mice. 26706782 2016
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.900 PosttranslationalModification disease BEFREE Novel phosphorylation of PPARγ ameliorates obesity-induced adipose tissue inflammation and improves insulin sensitivity. 26385316 2016
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
0.900 GeneticVariation disease BEFREE Metabolic and hormonal consequencies of the "obesity risk" MC4R variant (rs12970134) in Czech women. 26680479 2016
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
0.900 GeneticVariation disease BEFREE Functional characterization of a new human melanocortin-4 receptor homozygous mutation (N72K) that is associated with early-onset obesity. 25163632 2016
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
0.900 GeneticVariation disease CLINVAR The prevalence of obesity is on the increase in South Africa, and it is hypothesized that mutations in MC4R are a contributing factor. 26788538 2016
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
0.900 GeneticVariation disease BEFREE Deletion of the MC4R gene in a 9-year-old obese boy. 25747306 2016
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.900 PosttranslationalModification disease BEFREE RNA and DNA were isolated from primary human skeletal muscle cells (HSkMC) from lean and severely obese women following lipid incubation. mRNA expression and DNA methylation were quantified for genes that globally regulate FAO [PPARγ coactivator (PGC-1α), peroxisome proliferator-activated receptors (PPARs), nuclear respiratory factors (NRFs)]. 25670728 2016
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.900 Biomarker disease BEFREE Our results suggest that dietary supplement of isorhamnetin may be beneficial to prevent obesity and steatosis and PPARγ antagonists may be useful to treat hepatic steatosis. 26775807 2016
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.900 GeneticVariation disease BEFREE The results confirmed a positive relationship between the interaction term for β-3 adrenergic receptor genotype and PPARγ genotype and various periodontal markers in obese elderly females. 25855572 2016
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
0.900 GeneticVariation disease BEFREE Melanocortin-4 receptor gene mutations in obese Slovak children. 26047380 2016
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.900 GeneticVariation disease BEFREE Obesity and Pro12Ala Polymorphism of Peroxisome Proliferator-Activated Receptor-Gamma Gene in Healthy Adults: A Systematic Review and Meta-Analysis. 26361038 2016
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
0.900 GeneticVariation disease BEFREE We conclude that rare heterozygous MC4R mutations contribute to the onset of obesity only in a few cases in the Slovak population. 26244670 2016
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.900 AlteredExpression disease BEFREE The development of obesity and insulin resistance in 6-month-old MSG mice was also accompanied by decreased mRNA expressions of adiponectin, lipogenetic and lipolytic enzymes and peroxisome proliferator-activated receptor-gamma in fat while mRNA expressions of lipogenetic enzymes in the liver were enhanced. 26577083 2016
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
0.900 AlteredExpression disease BEFREE Associations between a common variant near the MC4R gene and serum triglyceride levels in an obese pediatric cohort. 25948074 2016
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.900 GeneticVariation disease BEFREE The 482Ser of PPARGC1A and 12Pro of PPARG2 Alleles Are Associated with Reduction of Metabolic Risk Factors Even Obesity in a Mexican-Mestizo Population. 26185753 2016
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
0.900 GeneticVariation disease BEFREE There is a synergistic effect of the high-risk alleles of the FTO and MC4R genes on the obese phenotype, while no impact on the metabolic abnormalities was observed in Greek obese children and adolescents. 25402378 2016