Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 177
Gene Symbol: AGER
AGER
0.400 AlteredExpression disease BEFREE However, serum sVAP-1 levels in OA patients were lower than in controls and inversely correlated with pain and inflammation markers (hsCRP and soluble RAGE). 31146362 2019
Entrez Id: 177
Gene Symbol: AGER
AGER
0.400 Biomarker disease BEFREE Receptor for advanced glycation end products (RAGE) is a multiligand receptor belonging to the immunoglobulin superfamily and plays crucial roles in the development of many human diseases such as neurodegenerative diseases, diabetes, cardiovascular diseases, osteoarthritis and cancer. 29477598 2018
Entrez Id: 177
Gene Symbol: AGER
AGER
0.400 Biomarker disease BEFREE Heparan sulfate has been shown to facilitate the binding of HMGB-1 to RAGE and could play a role in the progression of OA. 28474284 2017
Entrez Id: 177
Gene Symbol: AGER
AGER
0.400 GeneticVariation disease BEFREE Our results suggest that the investigated polymorphism in the RAGE gene play a role in OA in the Han Chinese population. 26436377 2015
Entrez Id: 177
Gene Symbol: AGER
AGER
0.400 Biomarker disease BEFREE Bioinformatics analysis showed increased mRNA expression of Damage-Associated Molecular Patterns (DAMPs): HMGA, HMGB, HMGN, SRY, LEF1, HMGB1, MMPs, and HMG/RAGE-interacting molecules (spondins and S100A4, S100A10, and S100A11) in human OA-affected cartilage as compared with normal cartilage. 24905701 2014
Entrez Id: 177
Gene Symbol: AGER
AGER
0.400 GeneticVariation disease BEFREE Of all three RAGE gene polymorphisms, only the genotype distributions and alleles frequencies of 82G/S polymorphisms significantly differed between knee OA and control subjects. 22987041 2012
Entrez Id: 177
Gene Symbol: AGER
AGER
0.400 Biomarker disease BEFREE In this study, we observed that RAGE knockout was not chondroprotective in instability-induced knee OA in 8-wk-old mice. 19342682 2009
Entrez Id: 177
Gene Symbol: AGER
AGER
0.400 AlteredExpression disease BEFREE Chondrocyte RAGE expression and S100A11 release are stimulated by IL-1beta in vitro and increase in OA cartilage in situ. 18523305 2008
Entrez Id: 177
Gene Symbol: AGER
AGER
0.400 Biomarker disease LHGDN Advanced glycation end products increases matrix metalloproteinase-1, -3, and -13, and TNF-alpha in human osteoarthritic chondrocytes. 17434489 2007
Entrez Id: 177
Gene Symbol: AGER
AGER
0.400 Biomarker disease CTD_human Increase in production of matrix metalloproteinase 13 by human articular chondrocytes due to stimulation with S100A4: Role of the receptor for advanced glycation end products. 16948116 2006
Entrez Id: 177
Gene Symbol: AGER
AGER
0.400 AlteredExpression disease LHGDN Articular chondrocytes express the receptor for advanced glycation end products: Potential role in osteoarthritis. 16052547 2005