Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.560 AlteredExpression disease BEFREE Intact LKB1 activity is required for survival of dormant ovarian cancer spheroids. 26068970 2016
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.560 AlteredExpression disease BEFREE In this study, we demonstrate that loss of cytoplasmic and nuclear LKB1 protein expression is frequently observed in tubal cancer precursor lesions as well as in both sporadic and hereditary HGSCs compared with other ovarian cancer histotypes. 25798842 2016
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.560 AlteredExpression disease BEFREE In this study, both the mRNA and protein expression levels of LKB1, p53, and p21 decreased in OCCs following transfection with a miR-17 expression plasmid. 25510663 2015
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.560 Biomarker disease BEFREE Loss of LKB1 and PTEN tumor suppressor genes in the ovarian surface epithelium induces papillary serous ovarian cancer. 24170201 2014
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.560 Biomarker disease BEFREE Recent studies showed that loss of function of LKB1 is associated with sporadic forms of lung, pancreatic, and ovarian cancer. 17761947 2008
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.560 GeneticVariation disease BEFREE The allele loss on 19p13.3 in ovarian cancers almost certainly targets a different gene from LKB1. 10389980 1999
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.560 GeneticVariation disease UNIPROT To investigate the involvement of STK11 gene in the development of ovarian carcinomas, we analyzed 30 ovarian carcinomas for loss of heterozygosity (LOH) and STK11 gene mutations. 10429654 1999
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.560 GeneticVariation disease UNIPROT Mutational analysis of STK11 gene in ovarian carcinomas. 10429654 1999
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.560 GeneticVariation disease UNIPROT Our results suggest that mutations of the STK11 gene may play a limited role in the development of ovarian carcinomas. 10429654 1999
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.560 GenomicAlterations disease CGI
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.560 CausalMutation disease CGI
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.500 Biomarker disease BEFREE Universal BRCA1/BRCA2 Testing for Ovarian Cancer Patients is Welcomed, but with Care: How Women and Staff Contextualize Experiences of Expanded Access. 28540621 2018
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.500 GeneticVariation disease BEFREE The First Nationwide Multicenter Prevalence Study of Germline BRCA1 and BRCA2 Mutations in Chinese Ovarian Cancer Patients. 28692638 2018
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.500 Biomarker disease BEFREE Changes in gene expression variability reveal a stable synthetic lethal interaction network in BRCA2-ovarian cancers. 28754563 2018
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.500 GeneticVariation disease BEFREE Biological and clinical evidence for somatic mutations in BRCA1 and BRCA2 as predictive markers for olaparib response in high-grade serous ovarian cancers in the maintenance setting. 28525389 2018
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.500 Biomarker disease BEFREE Long non-coding RNA RP11-552M11.4 promotes cells proliferation, migration and invasion by targeting BRCA2 in ovarian cancer. 29478268 2018
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.500 GeneticVariation disease GWASCAT We also identified a known breast cancer locus CASP8/ALS2CR12 associated with prostate cancer, a known cancer locus at CDKN2B-AS1 with different variants associated with lung adenocarcinoma and prostate cancer, and confirmed the associations of a breast BRCA2 locus with lung and serous ovarian cancer. 27197191 2017
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.500 Biomarker disease BEFREE A Cost-Effectiveness Evaluation of Germline BRCA1 and BRCA2 Testing in UK Women with Ovarian Cancer. 28407998 2017
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.500 Biomarker disease BEFREE Breast cancer 2 (BRCA2)-associated breast and ovarian cancers are sensitive to platinum-based chemotherapy. 28608931 2017
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.500 GeneticVariation disease BEFREE Key messages for communicating information about BRCA1 and BRCA2 to women with breast or ovarian cancer: Consensus across health professionals and service users. 28101941 2017
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.500 GeneticVariation disease BEFREE Evaluation of Polygenic Risk Scores for Breast and Ovarian Cancer Risk Prediction in BRCA1 and BRCA2 Mutation Carriers. 28376175 2017
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.500 GeneticVariation disease BEFREE Germline mutations in BRCA1 and BRCA2 are the most penetrating genetic predispositions for breast and ovarian cancer, and their presence is largely ethnic-specific. 26848529 2017
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.500 GeneticVariation disease BEFREE In May 2016, the Division of Cancer Prevention and the Division of Cancer Control and Population Sciences, National Cancer Institute, convened a workshop to discuss a conceptual framework for identifying and genetically testing previously diagnosed but unreferred patients with ovarian cancer and other unrecognized BRCA1 or BRCA2 mutation carriers to improve the detection of families at risk for breast or ovarian cancer. 28398847 2017
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.500 GeneticVariation disease BEFREE Mutations in BRCA1, BRCA2 and other breast and ovarian cancer susceptibility genes in Central and South American populations. 28985766 2017
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.500 GeneticVariation disease BEFREE BRCA1 and BRCA2 mutations in ovarian cancer patients from China: ethnic-related mutations in BRCA1 associated with an increased risk of ovarian cancer. 28176296 2017