| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.340 | Biomarker | disease | BEFREE | Our findings suggest that COX-2 may be involved in the improved therapeutic outcome seen in some pancreatic tumors that fail to respond to MEK or CDK4/6 inhibitors alone but respond favorably to their combination. | 30254182 | 2018 | ||||
|
0.340 | Biomarker | disease | CTD_human | COX-2 immunohistochemistry was performed in pancreata of hamsters subjected to the carcinogen N-nitrosobis-(2-oxopropyl)amine (BOP) and in human pancreatic tumors. | 16820089 | 2006 | ||||
|
0.340 | Biomarker | disease | CTD_human | These findings imply that assessing the COX-2 profile of the pancreatic tumor is mandatory before initiating therapy with a selective COX-2 inhibitor. | 15705899 | 2005 | ||||
|
0.340 | Biomarker | disease | LHGDN | Pancreatic stellate cells (PSCs) express cyclooxygenase-2 (COX-2) and pancreatic cancer stimulates COX-2 in PSCs. | 16083499 | 2005 | ||||
|
0.340 | Biomarker | disease | BEFREE | We compared the angiogenic characteristics of a COX-2-positive human pancreatic tumor cell line, BxPC-3, with those of a COX-2-negative pancreatic tumor cell line, AsPC-1. | 12533667 | 2003 | ||||
|
0.340 | Biomarker | disease | LHGDN | PGE(2) is generated by specific COX-2 activity and increases VEGF production in COX-2-expressing human pancreatic cancer cells. | 12821125 | 2003 | ||||
|
0.340 | AlteredExpression | disease | LHGDN | We compared the angiogenic characteristics of a COX-2-positive human pancreatic tumor cell line, BxPC-3, with those of a COX-2-negative pancreatic tumor cell line, AsPC-1. | 12533667 | 2003 | ||||
|
0.340 | Biomarker | disease | CTD_human | We also report that the COX inhibitors sulindac, indomethacin and NS-398 inhibit cell growth in both COX-2-positive (BxPC-3) and COX-2-negative (PaCa-2) pancreatic tumor cell lines. | 10657949 | 2000 | ||||
|
0.340 | Biomarker | disease | CTD_human | Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs. | 10485483 | 1999 |