Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 960
Gene Symbol: CD44
CD44
0.360 Biomarker disease BEFREE We have previously demonstrated that anti-CD44s H4C4 or liposomal-delivered STAT3 inhibitor FLLL32 sensitized pancreatic cancer cells to radiotherapy through the elimination or inhibition of cancer stem cells (CSCs) and that HAb18G/CD147 promoted STAT3-mediated pancreatic tumor development by forming a signaling complex with CD44s. 31312365 2019
Entrez Id: 960
Gene Symbol: CD44
CD44
0.360 Biomarker disease BEFREE This study has used the following in vitro and in vivo techniques for the investigation of exceptional anticancer drug FL118's efficacy in treatment of resistant pancreatic cancer: cell culture; immunoblotting analysis to test protein expression; DNA sub-G1 flow cytometry analyses to test cell death; MTT assay to test cell viability; pancreatic cancer stem cell assays (fluorescence microscopy tracing; matrigel assay; CD44-positive cell colony formation assay); human luciferase-labeled pancreatic tumor orthotopic animal model in vivo imaging; pancreatic cancer patient-derived xenograft (PDX) animal models; and toxicology studies with immune-competent BALB/cj mice and beagle dogs. 30285798 2018
Entrez Id: 960
Gene Symbol: CD44
CD44
0.360 AlteredExpression disease BEFREE Moreover, in human pancreatic ductal adenocarcinoma (PDAC) tissues, the expression patterns of KLF4 and CD44 were mutually exclusive, and this inverse relationship was particularly striking in human metastatic pancreatic tumors and in autochthonous mouse models of PDAC. 26880805 2016
Entrez Id: 960
Gene Symbol: CD44
CD44
0.360 Biomarker disease BEFREE Strategies to target CD44s cab be developed to block pancreatic tumor formation and post-radiotherapy recurrence in patients. 24397969 2014
Entrez Id: 960
Gene Symbol: CD44
CD44
0.360 Biomarker disease BEFREE This study demonstrates a central role of Notch signalling pathway in pancreatic cancer pathogenesis and identifies an effective approach to inhibit selectively EMT and suppress tumorigenesis by eliminating pancreatic tumor initiating CD44+/EpCAM+ cells. 23094026 2012
Entrez Id: 960
Gene Symbol: CD44
CD44
0.360 Biomarker disease CTD_human Establishment of clonal colony-forming assay for propagation of pancreatic cancer cells with stem cell properties. 17446842 2007
Entrez Id: 960
Gene Symbol: CD44
CD44
0.360 AlteredExpression disease BEFREE Diagnostic application of CD44 variant expression in pancreatic juice for detection of pancreatic neoplasm. 11501843 2001