Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1508
Gene Symbol: CTSB
CTSB
0.080 Biomarker disease BEFREE These studies set the stage for the generation of a preclinical mouse model of CTSB-dependent pancreatitis. 31235832 2019
Entrez Id: 1508
Gene Symbol: CTSB
CTSB
0.080 Biomarker disease BEFREE CTSC is a regulator and activator of various lysosomal enzymes such as cathepsin B, D, and L. Its loss mitigates the severity of pancreatitis not by reducing intra-acinar cell zymogen activation but by reducing infiltration of neutrophil granulocytes into the pancreas. 30455353 2019
Entrez Id: 1508
Gene Symbol: CTSB
CTSB
0.080 AlteredExpression disease BEFREE Intra-pancreatic trypsinogen activation by cathepsin B can occur in ferrets, which might trigger pancreatitis even in the absence of trypsinogen autoactivation. 30305676 2018
Entrez Id: 1508
Gene Symbol: CTSB
CTSB
0.080 AlteredExpression disease BEFREE Of note, the CTSD KO greatly reduced CTSB and trypsinogen activation in acinar cells, and CTSD directly activated CTSB but not trypsinogen <i>in vitro</i> During pancreatitis in pancreas-specific CTSD<sup>f/f</sup>/p48<sup>Cre/+</sup> animals, markers of severity were reduced only at 1 h, whereas in the complete KO, this effect also included the late disease phase (8 h), indicating an important effect of extra-acinar CTSD on course of the disease. 29229780 2018
Entrez Id: 1508
Gene Symbol: CTSB
CTSB
0.080 Biomarker disease BEFREE Transfer of macrophage from control mice to CTSB-knockout mice increased the severity of pancreatitis. 29079517 2018
Entrez Id: 1508
Gene Symbol: CTSB
CTSB
0.080 GeneticVariation disease BEFREE The accelerated activation of p.K23_I24insIDK by cathepsin B is a unique biochemical property not found in any other pancreatitis-associated trypsinogen mutant. 21499207 2011
Entrez Id: 1508
Gene Symbol: CTSB
CTSB
0.080 Biomarker disease BEFREE Cathepsin B is thought to play a central role in intrapancreatic trypsinogen activation and the onset of pancreatitis. 12102727 2002
Entrez Id: 1508
Gene Symbol: CTSB
CTSB
0.080 Biomarker disease BEFREE These observations confirm the presence of active cathepsin B in the human pancreatic secretory pathway and are consistent with the notion that cathepsin B-mediated trypsinogen activation might play a pathogenic role in human pancreatitis. 11932257 2002
Entrez Id: 1508
Gene Symbol: CTSB
CTSB
0.080 Biomarker disease LHGDN These observations confirm the presence of active cathepsin B in the human pancreatic secretory pathway and are consistent with the notion that cathepsin B-mediated trypsinogen activation might play a pathogenic role in human pancreatitis. 11932257 2002