Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.600 Biomarker disease BEFREE Loss-of-function of PINK1/Parkin-mediated mitophagy results in the accumulation of dysfunctional mitochondria, which could be one etiology of Parkinson's disease (PD). 31504668 2020
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.600 Biomarker disease BEFREE Particularly, it has been reported that mitophagy could hinder the development of PD by activating the PINK1/Parkin pathway and acting as a defense mechanism against the induction of diabetes. 31730816 2020
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.600 GeneticVariation disease BEFREE Cognitive impairment was reported in all monogenic PD forms with variable rates (58.8% PINK1, 53.9% SNCA, 50% DJ1, 29.2% VPS35, 15.7% LRRK2 and 7.4% Parkin). 31686421 2020
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.600 Biomarker disease BEFREE Using PINK1<sup>B9</sup> mutant Dm, we aimed to explore the therapeutic action of ginseng total protein (GTP) on PD and provide in-depth scientific interpretation about the traditional efficacy of ginseng. 31562951 2020
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.600 Biomarker disease BEFREE These results are significant in expanding knowledge of early-onset deficits in the female Pink1-/- genetic rat model of PD. 31542395 2020
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.600 GeneticVariation disease BEFREE In rare cases PD is caused by mutations in the genes for PINK1 (PTEN induced kinase 1) or PRKN (parkin RBR E3 ubiquitin protein ligase), which impair the selective autophagic elimination of damaged mitochondria (mitophagy). 30945962 2020
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.600 GeneticVariation disease BEFREE Pink1 mutations are the second most common cause of autosomal recessive Parkinson's disease (PD). 31655049 2020
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.600 Biomarker disease BEFREE This study presented a new evidence for PINK1 and Parkin in participating in mitochondrial quality control and provided clues for further revealing the role of PINK1 and Parkin in the pathogenesis of PD. 31727366 2020
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.600 Biomarker disease BEFREE <b>Abbreviations:</b> CCCP: carbonyl cyanide 3-chlorophenylhydrazone; DUB: deubiquitinating enzymes; MPTP: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; OMM: outer mitochondrial membrane; PD: Parkinson disease; PINK1: PTEN induced kinase 1; PRKN/PARK2: parkin RBR E3 ubiquitin protein ligase; ROS: reactive oxygen species; TM: transmembrane; Ub: ubiquitin; UBA1: ubiquitin like modifier activating enzyme 1; UBE2L3/UbcH7: ubiquitin conjugating enzyme E2 L3; USP33: ubiquitin specific peptidase 33; WT: wild type. 31432739 2020
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.600 GeneticVariation disease BEFREE The Parkinson's disease (PD)-related ubiquitin ligase Parkin and mitochondrial kinase PINK1 function together in the clearance of damaged mitochondria. 30375512 2019
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.600 GeneticVariation disease BEFREE Mutations of PINK1 and PRKN/PARK2 contribute to the risk of Parkinson disease. 30252570 2019
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.600 Biomarker disease BEFREE The Parkinson disease-associated proteins PINK1 and PRKN coordinate the ubiquitination of mitochondrial outer membrane proteins to tag them either for degradation or for autophagic clearance of the mitochondrion. 30806158 2019
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.600 Biomarker disease BEFREE It has been leveraged to generate PD animal models, such as Parkin, DJ-1, and PINK1 triple knockout miniature pigs. 30879240 2019
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.600 Biomarker disease BEFREE Several PD-related proteins are known to participate in the regulation of mitophagy, including PINK1 and Parkin. 31336937 2019
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.600 Biomarker disease BEFREE Mitochondrial import efficiency was abnormally low in cells from patients with PINK1- and PARK2-linked Parkinson's disease and was restored by phosphomimetic ubiquitin in cells with residual Parkin activity. 31413265 2019
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.600 AlteredExpression disease BEFREE Loss of either PINK1 or Parkin protein expression is associated with Parkinson's disease. 30885942 2019
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.600 GeneticVariation disease BEFREE Mutations of PTEN-induced kinase 1 (PINK1) cause recessive familial Parkinson's disease. 31362890 2019
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.600 Biomarker disease BEFREE We hypothesized that chronic psychological distress induces PD-like symptoms and promotes neurodegeneration in wild-type (WT) rats and exacerbates PD pathology in PINK1 knockout (KO) rats, a well-validated animal model of PD. 31836946 2019
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.600 Biomarker disease BEFREE Mice that lack the PD-linked kinase PINK1 show impaired differentiation of adult-born neurons in the hippocampus. 30735759 2019
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.600 Biomarker disease BEFREE This suggests that pink1, atp13a2 and uchl1 expressions are regulated by inflammation, and this regulatory mechanism might be involved in the progress of PD. 31201839 2019
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.600 Biomarker disease BEFREE Laryngeal muscle biology in the <i>Pink1-/-</i> rat model of Parkinson disease. 30844333 2019
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.600 GeneticVariation disease BEFREE Mutations in <i>PRKN</i> and PTEN-Induced Putative Kinase 1 (<i>PINK1</i>) are well-established causes of autosomal recessive early-onset PD. 31344817 2019
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.600 Biomarker disease BEFREE The role of PINK1 in mitochondrial function and in PD pathogenesis remains to be elucidated thoroughly. 30504091 2019
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.600 Biomarker disease BEFREE These data support the idea that PINK1 is a repressor of the immune system, and provide a pathophysiological model in which intestinal infection acts as a triggering event in Parkinson's disease, which highlights the relevance of the gut-brain axis in the disease<sup>10</sup>. 31316206 2019
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.600 AlteredExpression disease BEFREE LRRK2 impairs PINK1/Parkin-dependent mitophagy via its kinase activity: pathologic insights into Parkinson's disease. 30629163 2019