Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.700 Biomarker disease BEFREE Aggregation of α-Synuclein is central to the pathogenesis of Parkinson's disease (PD). 31836471 2020
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.700 AlteredExpression disease BEFREE Nigral overexpression of α-synuclein in a rat Parkinson's disease model indicates alterations in the enteric nervous system and the gut microbiome. 31576631 2020
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.700 Biomarker disease BEFREE Agonist activation of D3R increases dopamine concentration, decreases α-Syn accumulation, enhances secretion of brain derived neurotrophic factors (BDNF), ameliorates neuroinflammation, alleviates oxidative stress, promotes neurogenesis in the nigrostriatal pathway, interacts with D1R to reduce PD associated motor symptoms and ameliorates side effects of levodopa (L-DOPA) treatment. 31765822 2020
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.700 Biomarker disease BEFREE Administration of melatonin leads to inhibition of some pathways related to apoptosis, autophagy, oxidative stress, inflammation, α-synuclein aggregation, and dopamine loss in PD. 31388798 2020
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.700 Biomarker disease BEFREE α-Synuclein (α-Syn) is a key pathogenic protein in α-synucleinopathies including Parkinson disease and dementia with Lewy bodies. 31734439 2020
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.700 Biomarker disease BEFREE Parkinson's disease (PD) that afflicts millions of individuals worldwide is associated with deposits of aggregate-prone proteins (e.g., α-synuclein) and with mitochondrial dysfunction in neuronal cells. 31760107 2020
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.700 Biomarker disease BEFREE Misfolding of the neuronal protein α-synuclein into amyloid fibrils is a pathological hallmark of Parkinson's disease, a neurodegenerative disorder that has no cure. 31809698 2020
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.700 Biomarker disease BEFREE The clinical and pathological differences between synucleinopathies such as Parkinson's disease and multiple system atrophy have been postulated to stem from unique strains of α-synuclein aggregates, akin to what occurs in prion diseases. 31792467 2020
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.700 Biomarker disease BEFREE Parkinson's disease (PD), a common human neurodegenerative disorder, is characterized by the presence of intraneuronal Lewy bodies composed principally of abnormal aggregated and post-translationally modified α-synuclein. 31586624 2020
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.700 Biomarker disease BEFREE Much of PD research has focused on the role of α-synuclein aggregates in degeneration of SNpc dopamine neurons because of the impact of loss of striatal dopamine on the classical motor phenotypes. 31837424 2020
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.700 Biomarker disease BEFREE The application of exogenous alpha-synuclein fibrils via injection to animal models of PD has been shown to be a useful method to study prion-like propagation of pathological alpha-synuclein and of transmission pathways that play a critical role in recapitulating characteristics of synucleinopathies. 31721123 2020
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.700 Biomarker disease BEFREE A diagnosing system with aggregated α-synuclein encoded by SNCA gene is necessary to make the precautionary treatment against Parkinson's disease (PD). 31761041 2020
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.700 Biomarker disease BEFREE The misfolding and aggregation of the largely disordered protein, α-synuclein, is a central pathogenic event that occurs in the synucleinopathies; a group of neurodegenerative disorders that includes Parkinson's disease. 31848207 2020
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.700 GeneticVariation disease BEFREE In addition, those pathological neurofilament accumulations are known in α-synuclein in Parkinson's disease (PD), Aβ and tau in Alzheimer's disease (AD), polyglutamine in CAG trinucleotide repeat disorders, superoxide dismutase 1 (SOD1), TAR DNA-binding protein 43 (TDP43), neuronal FUS proteins, optineurin (OPTN), ubiquilin 2 (UBQLN2), and dipeptide repeat protein (DRP) in amyotrophic lateral sclerosis (ALS). 31820696 2020
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.700 AlteredExpression disease BEFREE Screening of the GBA1 gene and analysis of CSF levels of total alpha-synuclein were performed in 80 PD<sub>GBA</sub> , 80 PD<sub>GBA</sub> _<sub>wildtype</sub> and 39 healthy controls cross-sectionally. 31670439 2020
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.700 Biomarker disease BEFREE Our results establish a master regulatory mechanism of α-synuclein function and aggregation in mammalian cells, extending the functional repertoire of molecular chaperones and highlighting new perspectives for therapeutic interventions for Parkinson's disease. 31802003 2020
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.700 Biomarker disease BEFREE Given that impaired α-synuclein turnover is a hallmark of PD pathogenesis and cathepsin D is a key enzyme involved in α-synuclein degradation in neuronal cells, we have examined the relationship of glucocerebrosidase (GCase), cathepsin D and monomeric α-synuclein in human neural crest stem cell derived dopaminergic neurons. 31634558 2020
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.700 Biomarker disease BEFREE Typically, the structural conversion occurs by misfolding of a single disease-associated protein, such as α-synuclein (αS) in Parkinson's disease, amyloid-β in Alzheimer's disease, and prion protein (PrP) in transmissible spongiform encephalopathies (TSEs). 31635805 2020
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.700 Biomarker disease BEFREE Alpha-synuclein (α-syn) is a major component of Lewy bodies, which are the pathological hallmark in Parkinson's disease, and its genetic mutations cause familial forms of Parkinson's disease. 31643109 2020
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.700 Biomarker disease BEFREE One of the pathological proteins, alpha-synuclein (α-syn), accumulates in the brains of Parkinson disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA), which are designated as synucleinopathies. 31785806 2020
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.700 AlteredExpression disease BEFREE Dopaminergic (DAergic) degeneration and abnormal α-synuclein (α-syn) expression, phosphorylation and aggregation are observed in both the nigrostriatal system (NSS) and enteric nervous system (ENS) of patients with Parkinson's disease (PD). 31759083 2020
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.700 AlteredExpression disease BEFREE Distinct miRNAs have been demonstrated to be involved in the regulation of α-synuclein, a key player in PD pathogenesis; miR-153 and miR-223 are downregulated in the brain and serum of parkinsonian GFAP.HMOX1 transgenic mice where they directly regulate α-synuclein. 31800144 2020
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.700 GeneticVariation disease BEFREE Overall, there exists significant associations between SNCA rs11931074 polymorphism and the risk of PD under five genetic models (allele contrast model: T vs. G, OR = 1.28, 95% CI = 1.12-1.45, P = 0.0001; homozygote model: TG vs. GG, OR = 1.55, 95% CI = 1.17-2.05, P = 0.002; heterozygote model (TT vs. GG, OR = 1.23, 95% CI = 1.05-1.42, P = 0.009; dominant model: TG+TT vs. GG: OR = 1.25, 95% CI = 1.05-1.50, P = 0.01 and recessive model: TT vs. TG+GG: OR = 1.40, 95% CI = 1.18-1.68, P = 0.0002). 31758346 2020
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.700 Biomarker disease BEFREE The catecholaldehyde hypothesis posits that diseases featuring catecholaminergic neurodegeneration result from harmful interactions between DOPAL and the protein alpha-synuclein, a major component of Lewy bodies in diseases such as Parkinson disease, dementia with Lewy bodies, and pure autonomic failure. 31807952 2020
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.700 Biomarker disease BEFREE Numerous post-translational modifications (PTMs) of the Parkinson's disease (PD) associated α-synuclein (α-syn) protein have been recognised to play critical roles in disease aetiology. 31753312 2020