Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2661
Gene Symbol: GDF9
GDF9
0.400 Biomarker disease BEFREE GDF9 and BMP15 associations with oocyte number differed significantly (P < 0.05) with PCOS status. 31211369 2019
Entrez Id: 2661
Gene Symbol: GDF9
GDF9
0.400 Biomarker disease BEFREE Concentrations of GDF9 showed significantly higher concentrations in PCO FFs of follicles >6 mm. 31287539 2019
Entrez Id: 2661
Gene Symbol: GDF9
GDF9
0.400 Biomarker disease BEFREE The immunoreactivity of growth differentiation factor 9 and bone morphogenetic protein 15 proteins decreased (p<0.05) in the Polycystic ovary syndrome group (27.73±8.43 and 24.85±7.03, respectively) compared with the control group (33.72±11.22 and 31.12±11.05, respectively) and vehicle group (33.95±10.75 and 29.99±10.72, respectively). 28903889 2018
Entrez Id: 2661
Gene Symbol: GDF9
GDF9
0.400 Biomarker disease BEFREE In the present study, we examined the role of ring finger protein 6 (RNF6) in AR ubiquitination and the possible dysregulation in the expression and actions of growth differentiation factor 9 (GDF9) and kit-ligand (Kitlg) in a chronic androgenized PCOS rat model. 28860512 2017
Entrez Id: 2661
Gene Symbol: GDF9
GDF9
0.400 Biomarker disease BEFREE Fourteen mutations in human (h) GDF9 have been reported in women with premature ovarian failure or polycystic ovarian syndrome as well as in mothers of dizygotic twins, implicating GDF9 in the etiology of these conditions. 24438375 2014
Entrez Id: 2661
Gene Symbol: GDF9
GDF9
0.400 AlteredExpression disease BEFREE In Graafian follicles, GDF9 and BMP15 expression reached comparable levels in the PCOS and control groups (P > 0.05). 25172094 2014
Entrez Id: 2661
Gene Symbol: GDF9
GDF9
0.400 AlteredExpression disease BEFREE The abundance of GDF9 mRNA was significantly lower (P < 0.01) while the abundance of BMP15 mRNA was significantly higher (P < 0.001) in GCs from stimulated-PCOS group than in unstimulated-PCOS group. 23912750 2013
Entrez Id: 2661
Gene Symbol: GDF9
GDF9
0.400 Biomarker disease CTD_human We inferred that BMP15 and GDF9 transcript levels increase in mature PCOS oocytes after COH, and might inhibit the progesterone secretion by follicular cells in PCOS follicles, preventing premature luteinization in cumulus cells. 22825968 2012
Entrez Id: 2661
Gene Symbol: GDF9
GDF9
0.400 AlteredExpression disease BEFREE We inferred that BMP15 and GDF9 transcript levels increase in mature PCOS oocytes after COH, and might inhibit the progesterone secretion by follicular cells in PCOS follicles, preventing premature luteinization in cumulus cells. 22825968 2012
Entrez Id: 2661
Gene Symbol: GDF9
GDF9
0.400 AlteredExpression disease BEFREE Abnormal expression of growth differentiation factor 9 and bone morphogenetic protein 15 in stimulated oocytes during maturation from women with polycystic ovary syndrome. 21669410 2011
Entrez Id: 2661
Gene Symbol: GDF9
GDF9
0.400 GeneticVariation disease BEFREE The above-mentioned mutations indicate GDF9 may be potentially associated with PCOS patients. 20705511 2010
Entrez Id: 2661
Gene Symbol: GDF9
GDF9
0.400 Biomarker disease BEFREE Certain GDF9 variants were associated with hirsutism scores and parity in PCOS patients.GDF9 may thus serve as a modifier gene. 20236105 2010
Entrez Id: 2661
Gene Symbol: GDF9
GDF9
0.400 AlteredExpression disease BEFREE However, the expression of GDF-9 in cumulus GCs of patients with PCOS was decreased significantly compared with controls (8.88 +/- 1.52 vs. 5.01 +/- 0.83). 19376510 2010
Entrez Id: 2661
Gene Symbol: GDF9
GDF9
0.400 AlteredExpression disease BEFREE To address this issue, we compared the pattern and level of expression of GDF-9 and BMP-15 mRNA in ovaries from normal cycling (n = 12), PCOS (n = 5), and PCO (n = 7) patients. 11889206 2002
Entrez Id: 2661
Gene Symbol: GDF9
GDF9
0.400 GeneticVariation disease BEFREE The missense mutation in the GDF-9 gene or the GDF-9B/BMP-15 gene is uncommon in anovulatory Japanese women with POF and PCOS. 11056243 2000