Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9021
Gene Symbol: SOCS3
SOCS3
0.040 GeneticVariation disease BEFREE Here we report a PV patient heterozygous for the somatic JAK2(N542-E543del) mutation and a previously unreported germline mutation within the SH2 domain of SOCS3 (F136L). 19735488 2009
Entrez Id: 9021
Gene Symbol: SOCS3
SOCS3
0.040 GeneticVariation disease BEFREE SOCS3 transcript levels were highest in patients with polycythemia vera and other JAK2 V617F positive myeloproliferative disorders, consistent with SOCS3 being a target gene of JAK2/STAT5 signaling. 18815196 2008
Entrez Id: 9021
Gene Symbol: SOCS3
SOCS3
0.040 AlteredExpression disease LHGDN Overexpression of SOCS-2 and SOCS-3 genes reverses erythroid overgrowth and IGF-I hypersensitivity of primary polycythemia vera (PV) cells. 17325857 2007
Entrez Id: 9021
Gene Symbol: SOCS3
SOCS3
0.040 GeneticVariation disease BEFREE The evolving evidence that JAK2 V617F is not specific for polycythemia vera pathogenesis and the development of disease phenotype is presented as well as alternative candidates for pathogenic mutations such as the protein tyrosine phosphatases and SOCS-3. 16781479 2006