Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 367
Gene Symbol: AR
AR 		0.600 GeneticVariation group LHGDN Polymorphic CAG repeats in the androgen receptor gene, prostate-specific antigen polymorphism and prostate cancer risk. 12376473 2002
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.600 PosttranslationalModification group LHGDN Determining risk of biochemical recurrence in prostate cancer by immunohistochemical detection of PTEN expression and Akt activation. 17606718 2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.600 Biomarker group LHGDN The role of PTEN in prostate cancer cell tropism to the bone micro-environment. 17347137 2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.600 GeneticVariation group LHGDN PTEN mutations do not cause nuclear beta-catenin accumulation in endometrial carcinomas. 15492994 2004
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.600 Biomarker group LHGDN [Role of PTEN protein in multidrug resistance of prostate cancer cells]. 18702307 2008
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.600 Biomarker group CTD_human Integrative molecular concept modeling of prostate cancer progression. 17173048 2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.600 GeneticVariation group BEFREE To further define the role of PTEN/MMAC1 in the development of prostate cancer and its spectrum of genetic alterations, we analysed 40 pT2 or pT3 prostate tumors for allelic loss, mutations, and homozygous deletions using PCR-based methods. 9788441 1998
Entrez Id: 367
Gene Symbol: AR
AR 		0.600 AlteredExpression group LHGDN AKT-independent protection of prostate cancer cells from apoptosis mediated through complex formation between the androgen receptor and FKHR. 12482965 2003
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.600 AlteredExpression group LHGDN Insulin growth factor-binding protein 2 is a candidate biomarker for PTEN status and PI3K/Akt pathway activation in glioblastoma and prostate cancer. 17372210 2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.600 Biomarker group CTD_human Dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced prostate carcinogenesis in CYP1A-humanized mice. 22581815 2012
Entrez Id: 3479
Gene Symbol: IGF1
IGF1 		0.600 Biomarker group BEFREE IGF-1 elevation led to the accumulation of FOXO3A in the cytosol of prostate tumor cells and downregulation of its target gene Bim, which resulted in the apoptosis inhibition and prostate cancer overgrowth. 31312023 2019
Entrez Id: 367
Gene Symbol: AR
AR 		0.600 AlteredExpression group LHGDN Activation of the androgen receptor N-terminal domain by interleukin-6 via MAPK and STAT3 signal transduction pathways. 11751884 2002
Entrez Id: 367
Gene Symbol: AR
AR 		0.600 Biomarker group LHGDN Regulation of androgen receptor transcriptional activity by rapamycin in prostate cancer cell proliferation and survival. 18776922 2008
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.600 AlteredExpression group LHGDN Pten inactivation and the emergence of androgen-independent prostate cancer. 17638861 2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.600 Biomarker group BEFREE This report describes a novel mouse model that overexpresses ERG and lacks PTEN with the majority of mice developing prostate tumors by 6 mo. 25007053 2014
Entrez Id: 367
Gene Symbol: AR
AR 		0.600 GeneticVariation group LHGDN Polymorphisms in genes regulating androgen activity among prostate cancer low-risk Inuit men and high-risk Scandinavians. 17376218 2008
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.600 Biomarker group LHGDN Downregulation of PTEN/MMAC/TEP1 expression in human prostate cancer cell line DU145 by growth stimuli. 12190124 2002
Entrez Id: 367
Gene Symbol: AR
AR 		0.600 Therapeutic group CTD_human Antiandrogen bicalutamide promotes tumor growth in a novel androgen-dependent prostate cancer xenograft model derived from a bicalutamide-treated patient. 16266977 2005
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.600 Biomarker group BEFREE We have quantitatively analyzed the mRNA levels of TMPRSS2-ERG, ERG, PTEN, and AR (n = 83), as well as ERG immunostaining (n = 78) in a series of prostate tumors. 25939480 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.600 AlteredExpression group LHGDN NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss. 16697957 2006
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.600 Biomarker group LHGDN Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation. 16432235 2006
Entrez Id: 367
Gene Symbol: AR
AR 		0.600 Biomarker group CTD_human Successful Treatment of Advanced Metastatic Prostate Cancer following Chemotherapy Based on Molecular Profiling. 22666205 2012
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.600 Biomarker group BEFREE Furthermore, ADT combined with vaccination, specifically a DNA vaccine encoding the ligand-binding domain of the AR, led to improved antitumor responses as measured by tumor volumes and delays in the emergence of castrate-resistant prostate tumors in two murine prostate cancer models (Myc-CaP and prostate-specific PTEN-deficient mice). 29051161 2017
Entrez Id: 367
Gene Symbol: AR
AR 		0.600 Biomarker group LHGDN Androgen receptor signaling and vitamin D receptor action in prostate cancer cells. 15754350 2005
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.600 AlteredExpression group LHGDN Elevated Skp2 protein expression in human prostate cancer: association with loss of the cyclin-dependent kinase inhibitor p27 and PTEN and with reduced recurrence-free survival. 12429629 2002