Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 PosttranslationalModification group BEFREE Analyzing potential molecular reasons, we found in RP-PCa and RP-BPH in comparison to TUR-BPH a significant hypomethylation of IGF2-DMR0, which coincided with hypermethylation of GSTP1-promoter, a prominent marker of prostate tumors. 29017567 2017
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 GeneticVariation group BEFREE Somatic mutations in the genomes of prostate tumors have been repeatedly reported to include deletion and gain of the 8p and 8q chromosomal regions, respectively; epigenetic gene silencing of glutathione S-transferase Pi(GSTP1); as well as mutations in androgen receptor gene. 22085526 2012
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 Biomarker group CTD_human Dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced prostate carcinogenesis in CYP1A-humanized mice. 22581815 2012
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 Biomarker group CTD_human Xenobiotic metabolizing gene variants, dietary heterocyclic amine intake, and risk of prostate cancer. 19223546 2009
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 Biomarker group BEFREE Among these genes was the known candidate prostate tumor suppressor GSTP1 (involved in xenobiotic detoxification). 18500686 2008
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 Biomarker group LHGDN Glutathione S-transferase Pi mediates proliferation of androgen-independent prostate cancer cells. 18413363 2008
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 PosttranslationalModification group LHGDN Promoter hypermethylation in circulating blood cells identifies prostate cancer progression. 17960617 2008
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 AlteredExpression group BEFREE In prostate tumors, expression of GST pi (encoded by GSTP1) is frequently lost because of promoter hypermethylation. 17415778 2007
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 PosttranslationalModification group BEFREE The silencing of GSTP1, due to aberrant methylation at the CpG island in the promoter/5'-UTR, occurs in the vast majority of prostate tumors and precancerous lesions. 16921492 2007
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 PosttranslationalModification group LHGDN Hypermethylation of the CpG islands in the promoter region flanking GSTP1 gene is a potential plasma DNA biomarker for detecting prostate carcinoma. 17291695 2007
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 Biomarker group CTD_human Integrative molecular concept modeling of prostate cancer progression. 17173048 2007
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 PosttranslationalModification group LHGDN In silico mining identifies IGFBP3 as a novel target of methylation in prostate cancer. 17453001 2007
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 GeneticVariation group LHGDN Prostate cancer risk from occupational exposure to polycyclic aromatic hydrocarbons interacting with the GSTP1 Ile105Val polymorphism. 17067754 2006
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 PosttranslationalModification group LHGDN Gene promoter methylation in prostate tumor-associated stromal cells. 16478744 2006
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 Biomarker group CTD_human Association of CYP17, GSTP1, and PON1 polymorphisms with the risk of prostate cancer. 15538743 2005
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 Biomarker group BEFREE From the translational standpoint, we should make an effort to validate the use of some hypermethylated genes as biomarkers of the disease; for example, it may occur with MGMT and GSTP1 in brain and prostate tumors, respectively. 15822191 2005
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 GeneticVariation group LHGDN Association of CYP17, GSTP1, and PON1 polymorphisms with the risk of prostate cancer. 15538743 2005
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 GeneticVariation group LHGDN Gluthatione-S-transferase P1 polymorphism I105V in familial and sporadic prostate cancer. 15527908 2004
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 Biomarker group LHGDN Optimal use of a panel of methylation markers with GSTP1 hypermethylation in the diagnosis of prostate adenocarcinoma. 15328191 2004
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 AlteredExpression group LHGDN Glutathione S-transferase pi is upregulated in the stromal compartment of hormone independent prostate cancer. 12746833 2003
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 AlteredExpression group BEFREE Expression of glutathione S-transferase pi (GSTP1), a detoxification enzyme that also binds steroid hormones, is diminished or absent in human prostate tumors possibly because of promoter hypermethylation. 11796315 2002
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 PosttranslationalModification group BEFREE The CpG island-associated with the GSTP1 gene is an intriguing example of a CpG rich region which is susceptible to hypermethylation in the majority of prostate tumours and yet is unmethylated in the normal prostate cell. 11850822 2002
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 AlteredExpression group LHGDN Reversal of GSTP1 CpG island hypermethylation and reactivation of pi-class glutathione S-transferase (GSTP1) expression in human prostate cancer cells by treatment with procainamide. 11751372 2001
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 Biomarker group CTD_human Protection against 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine cytotoxicity and DNA adduct formation in human prostate by glutathione S-transferase P1. 11196146 2001
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 GeneticVariation group BEFREE Methylation-specific polymerase chain reaction (MSP) targeting promoter hypermethylation of the glutathione S transferase P1 gene (GSTP1), as the most frequent DNA alteration in prostatic carcinoma, was used for the molecular detection of cell-bound and cell-free prostate tumor DNA in various human bodily fluids. 11708494 2001