Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.600 Biomarker group BEFREE Furthermore, we showed in preclinical models that BRG1 antagonist selectively inhibited the progression of PTEN-deficient prostate tumors. 30496141 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.600 Biomarker group BEFREE PTEN loss stimulates prostate tumor progression by sustaining AKT activation.Nowak et al.(2019.<i>J. 31145683 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.600 Biomarker group CTD_human Cribriform and intraductal prostate cancer are associated with increased genomic instability and distinct genomic alterations. 29295717 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.600 Biomarker group CTD_human The long tail of oncogenic drivers in prostate cancer. 29610475 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.600 Biomarker group CTD_human An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer. 29335545 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.600 Biomarker group BEFREE High intracellular ROS levels selectively sensitize cells displaying hyperactive Akt to ROS-induced cell death enabling a therapeutic strategy combining a ROS inducer and rapamycin in PTEN-deficient prostate tumors in mouse models. 29687779 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.600 Biomarker group BEFREE Furthermore, ADT combined with vaccination, specifically a DNA vaccine encoding the ligand-binding domain of the AR, led to improved antitumor responses as measured by tumor volumes and delays in the emergence of castrate-resistant prostate tumors in two murine prostate cancer models (Myc-CaP and prostate-specific PTEN-deficient mice). 29051161 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.600 Biomarker group CTD_human A single-copy Sleeping Beauty transposon mutagenesis screen identifies new PTEN-cooperating tumor suppressor genes. 28319090 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.600 AlteredExpression group BEFREE Here, we provide evidence that PTEN loss in prostate tumours upregulates the expression of ADAM17, thereby activating NOTCH signalling. 27941799 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.600 GeneticVariation group BEFREE We studied the sensitivity and specificity of PTEN immunohistochemistry relative to four-color fluorescence in situ hybridization (FISH) for detection of PTEN gene deletion in a multi-institutional cohort of 731 primary prostate tumors. 27174589 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.600 Biomarker group BEFREE We have quantitatively analyzed the mRNA levels of TMPRSS2-ERG, ERG, PTEN, and AR (n = 83), as well as ERG immunostaining (n = 78) in a series of prostate tumors. 25939480 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.600 Biomarker group BEFREE Met was amplified in 67% of prostate tumors from Pten p53 prostate conditional null mice and in approximately 30% of metastatic human prostate cancer specimens, often in association with loss of PTEN and TP53. 25381262 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.600 Biomarker group BEFREE PTEN loss in Gleason score 6 biopsies identifies a subset of prostate tumors at increased risk of upgrading at radical prostatectomy. 24993522 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.600 Biomarker group BEFREE KLF5 loss enhances tumor angiogenesis by attenuating PI3K/AKT signaling and subsequent accumulation of HIF1α in PTEN deficient prostate tumors. 25896712 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.600 Biomarker group BEFREE This report describes a novel mouse model that overexpresses ERG and lacks PTEN with the majority of mice developing prostate tumors by 6 mo. 25007053 2014
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.600 Biomarker group BEFREE Here, we show that AKT2 is exclusively required for PTEN-deficient prostate tumor spheroid maintenance, whereas AKT1 is dispensable. shRNA silencing of AKT2 but not AKT1 promotes regression of prostate cancer xenografts. 24838891 2014
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.600 Biomarker group BEFREE Here we show that at the onset of senescence, PTEN null prostate tumours in mice are massively infiltrated by a population of CD11b(+)Gr-1(+) myeloid cells that protect a fraction of proliferating tumour cells from senescence, thus sustaining tumour growth. 25156255 2014
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.600 Biomarker group CTD_human Dietary resveratrol prevents development of high-grade prostatic intraepithelial neoplastic lesions: involvement of SIRT1/S6K axis. 23248098 2013
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.600 Biomarker group BEFREE Behavioral stress inhibited apoptosis and delayed prostate tumor involution both in phosphatase and tensin homolog-deficient (PTEN-deficient) prostate cancer xenografts treated with PI3K inhibitor and in prostate tumors of mice with prostate-restricted expression of c-MYC (Hi-Myc mice) subjected to androgen ablation therapy with bicalutamide. 23348742 2013
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.600 GeneticVariation group BEFREE Using the conditional PTEN deletion mouse model, we previously reported that survivin levels increase with prostate tumor growth. 23936028 2013
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.600 Biomarker group CTD_human Dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced prostate carcinogenesis in CYP1A-humanized mice. 22581815 2012
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.600 AlteredExpression group BEFREE Immunofluorescence data and western blot analyses determined that a lentivirus containing a 5'UTR derived from FGF-2 is the best candidate for directing selective gene expression in the prostate tumors of PTEN(-/-) mice in vivo. 21921943 2012
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.600 Biomarker group CTD_human Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer. 22610119 2012
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.600 AlteredExpression group BEFREE IGF-IR expression positively correlates with PTEN and inversely correlates with NRP2 in prostate tumors. 22777769 2012
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.600 Biomarker group CTD_human Resveratrol and prostate cancer: promising role for microRNAs. 21714127 2011