Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression disease BEFREE Keratinocyte growth factor expression by fibroblasts in pulmonary fibrosis: poor response to interleukin-1beta. 15677771 2005
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression disease BEFREE We observed significant up-regulation of IL-1β and IL-6 in bronchoalveolar lavage fluid (BALF) in bleomycin-induced lung fibrosis in vivo. 23526221 2013
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease BEFREE Hesperidin alleviates BLM-induced IPF via inhibition of TGF-β1/Smad3/AMPK and IκBα/NF-κB pathways which in turn ameliorate the modulation of oxido-inflammatory markers (Nrf2 and HO-1) and pro-inflammatory markers (TNF-α, IL-1β, and IL-6) to reduce collagen deposition during pulmonary fibrosis.See also Figure 1(Fig.1). 31611754 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease BEFREE In particular, nalp3 mediated inflammasome activation of caspase-1 and conversion of pro-IL-1 to IL-1 play a key role in silica-mediated and bleomycin-mediated pulmonary fibrosis. 19633559 2009
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease BEFREE Additionally, GPS significantly decreased the levels of inflammatory cytokines including TNF-α and IL-1β in bronchoalveolar lavage fluid and reduced the content of hydroxyproline in lungs of PF mice. 29278701 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression disease BEFREE Withaferin A treatment reduced the progression of PF by modulating the EMT related cell markers both <i>in vivo</i> and <i>in vitro.</i> Withaferin A ameliorated the expression of inflammatory cytokines including NF-κB p65, IL-1β and TNF-α, as well as attenuated the expression of pro-fibrotic proteins including CTGF, collagen 1A2, collagen 3A1, and fibronectin. 29623041 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease BEFREE Statistical analysis confirms a correlation between IL-1β production in BMDM and the lung fibrosis. 28677920 2017
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease BEFREE IL-1 receptor antagonist-deficient (IL-1Ra-KO) mice were more severely affected by BLM injection, as shown by dermal and pulmonary fibrosis, compared with wild-type (WT) mice. 30042768 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease CTD_human Neutralization of interleukin-1 beta attenuates silica-induced lung inflammation and fibrosis in C57BL/6 mice. 23640035 2013
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression disease BEFREE After 21 days of exposure to PM<sub>2.5</sub> through oropharyngeal aspiration, Balb/c mice showed increased IL-1β and TGF-β1 levels in the bronchoalveolar lavage fluid (BALF) of lung and significant collagen deposition around small airways of mice, suggesting potential lung inflammation and pulmonary fibrosis. 30092543 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease RGD Modulatory effects of curcumin and green tea extract against experimentally induced pulmonary fibrosis: a comparison with N-acetyl cysteine. 23132788 2012
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression disease BEFREE Collectively, IkBα-NFkB signaling activation by Hsp27, which resulted in the facilitation of Twist, IL1β, and IL6 expression, is involved in the EMT process that is tightly connected to the development of IR-induced lung fibrosis. 31126962 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease RGD Phosphodiesterase-5 inhibition by sildenafil citrate in a rat model of bleomycin-induced lung fibrosis. 19945540 2010
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease CTD_human Levels of cytokine in bronchoalveolar lavage (BAL) fluid in patients with pulmonary fibrosis due to sulfur mustard gas inhalation. 17266442 2007