Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7056
Gene Symbol: THBD
THBD
0.550 AlteredExpression disease BEFREE Previous studies have reported that circulating levels of soluble thrombomodulin (TM) reflect endothelial injuries, which play key roles in the development of ARDS. 27976836 2017
Entrez Id: 7056
Gene Symbol: THBD
THBD
0.550 AlteredExpression disease BEFREE The dysregulation of EPCR and TM in the lung, especially in those with increased levels of hemozoin, may play an important role in the pathogenesis of malaria-associated ARDS through an apoptotic pathway. 28732053 2017
Entrez Id: 7056
Gene Symbol: THBD
THBD
0.550 GeneticVariation disease BEFREE Genetic variants in thrombomodulin and endothelial protein C receptor genes are additively associated with mortality in ARDS. 27215212 2016
Entrez Id: 7056
Gene Symbol: THBD
THBD
0.550 AlteredExpression disease BEFREE Plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome. 25643902 2015
Entrez Id: 7056
Gene Symbol: THBD
THBD
0.550 Biomarker disease BEFREE Involvement of high mobility group box 1 and the therapeutic effect of recombinant thrombomodulin in a mouse model of severe acute respiratory distress syndrome. 23607598 2013
Entrez Id: 7056
Gene Symbol: THBD
THBD
0.550 Biomarker disease CTD_human Alterations in endothelial thrombomodulin expression in zymosan-induced lung injury. 12707536 2003
Entrez Id: 7056
Gene Symbol: THBD
THBD
0.550 Biomarker disease RGD Alterations in endothelial thrombomodulin expression in zymosan-induced lung injury. 12707536 2003
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.510 AlteredExpression disease BEFREE In addition, CS delivery exposes infants to a higher risk of respiratory distress syndrome and its concomitant increase in endothelin-1 levels, which might indirectly lead to a higher risk of developing PPHN. 29058246 2017
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.510 Biomarker disease CTD_human Effects of endothelin receptor antagonism on acute lung injury induced by chlorine gas. 16625121 2006
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.510 Therapeutic disease RGD Thus, we examined the effects of Ang-1 on ET-1 production in vitro and in vivo and investigated cell-based gene transfer of Ang-1 in a rat model of lipopolysaccharide (LPS)-induced ARDS. 16741035 2006
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.510 Biomarker disease RGD Release of endothelin in the oleic acid-induced respiratory distress syndrome in rats. 1618274 1992
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
0.500 Biomarker disease CTD_human MicroRNA and mRNA expression profiling in rat acute respiratory distress syndrome. 25070658 2014
Entrez Id: 10266
Gene Symbol: RAMP2
RAMP2
0.500 Biomarker disease CTD_human MicroRNA and mRNA expression profiling in rat acute respiratory distress syndrome. 25070658 2014
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
0.500 Biomarker disease RGD MicroRNA and mRNA expression profiling in rat acute respiratory distress syndrome. 25070658 2014
Entrez Id: 10266
Gene Symbol: RAMP2
RAMP2
0.500 Biomarker disease RGD [Alterations of intermedin and its receptor system in oleic acid-induced acute lung injury of rats]. 17068622 2006
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.340 AlteredExpression disease BEFREE When patients with VAP developed adult respiratory distress syndrome (ARDS), their plasma MCP-1 concentrations were significantly higher than those of patients who did not develop ARDS (<i>p</i> = 0.04). 31064097 2019
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.340 Biomarker disease BEFREE BAL fluid from patients with ARDS was highly chemotactic for human neutrophils and neutralising either CCL2 or CCL7 attenuated the neutrophil chemotactic response. 27496101 2017
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.340 Biomarker disease CTD_human MicroRNA and mRNA expression profiling in rat acute respiratory distress syndrome. 25070658 2014
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.340 Biomarker disease BEFREE The expression of IL-6, IL-10, IFNγ, and MCP-1, key chemokines/cytokines implicated in the development of ALI/ARDS, from both the inflammatory infiltrate and whole lung tissue were modulated by curcumin potentially through a reduction in the phosphorylated form of NFκB p65. 23437361 2013
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.340 AlteredExpression disease BEFREE The chemokine CCL2 is a potent inducer of macrophage recruitment and activation, and its expression is elevated in patients with ARDS. 21741938 2011
Entrez Id: 213
Gene Symbol: ALB
ALB
0.320 Biomarker disease BEFREE Age, infection, heart rate, PaO2/FiO2, ALB, and APACHE II scores may be related to prognosis of patients with ARDS after abdominal surgery. 30651777 2019
Entrez Id: 213
Gene Symbol: ALB
ALB
0.320 AlteredExpression disease BEFREE Flow cytometry demonstrated that albumin levels and numbers of inflammatory cells (Ly6G+/CD14+/CD68+/CD11<sup>b/c</sup>+) in bronchoalveolar lavage fluid were the highest in untreated ARDS, were progressively reduced across SW, Mito, and SW + Mito (all <i>p</i> < 0.0001), and were the lowest in sham controls. 30420790 2018
Entrez Id: 213
Gene Symbol: ALB
ALB
0.320 Therapeutic disease CTD_human Albumin and furosemide therapy in hypoproteinemic patients with acute lung injury. 12394941 2002
Entrez Id: 4504
Gene Symbol: MT3
MT3
0.310 Biomarker disease BEFREE AJs: adherens junctions; ALI: acute lung injury; ARDS: acute respiratory distress syndrome; ATG5: autophagy related 5; ATG12: autophagy related 12; ATG 16L1: autophagy related 16 like; 1 BALF: bronchoalveolar lavage fluidCQ: chloroquine; Ctrl: control; EC: endothelial cell; GFP: green fluorescent protein; HA-tagged; RAB26<sup>WT</sup>: HA-tagged wild-type; RAB26  HA-tagged; RAB26<sup>QL</sup>: HA-tagged; RAB26<sup>Q123L</sup>HA-tagged; RAB26<sup>NI</sup>: HA-tagged; RAB26<sup>N177I</sup>HPMECs: human pulmonary microvascular endothelial cells; H&E: hematoxylin & eosin; IgG: immunoglobulin; GIF: immunofluorescence; IP: immunoprecipitationi;. p.: intraperitoneal; LPS: lipopolysaccharide; PBS: phosphate-buffered salinesi; RNA: small interfering;RNASQSTM1/p62, sequestosome; 1TBS: Tris-buffered saline; VEGF: vascular endothelial growth factor; WB: western blot; WT: wild-type. 29965781 2018
Entrez Id: 56994
Gene Symbol: CHPT1
CHPT1
0.310 Biomarker disease BEFREE The population-based frequency of mutations in the phosphatidylcholine synthesis pathway-associated genes PCYT1B LPCAT1, CHPT1 is low in southern Chinese newborns and there is no evidence of contribution to population-based disease burden of respiratory distress syndrome. 29411327 2018