Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2308
Gene Symbol: FOXO1
FOXO1
0.100 Biomarker disease BEFREE Together with the observed effects on the PAX3-FOXO1 fusion protein, these data suggest SAHA as a possible therapeutic agent for clinical testing in patients with fusion protein-positive RMS. 30307360 2019
Entrez Id: 2308
Gene Symbol: FOXO1
FOXO1
0.100 Biomarker disease BEFREE This is supported in rhabdomyosarcoma models by characterization of molecular and phenotypic effects of reducing and inhibiting PLK1, including changes to the PAX3-FOXO1 fusion protein. 31824851 2019
Entrez Id: 2308
Gene Symbol: FOXO1
FOXO1
0.100 Biomarker disease BEFREE This study describes the in vitro and in vivo activity of PXD-101 (Belinostat), a novel hydroxamic acid-type pan-HDACs inhibitor characterized by a larger safety and efficacy, on myogenic-derived PAX3/FOXO1 fusion protein positive (RH30) or negative (RD) expressing rhabdomyosarcoma (RMS) cell lines. 31325529 2019
Entrez Id: 2308
Gene Symbol: FOXO1
FOXO1
0.100 Biomarker disease BEFREE We previously identified the class I-specific histone deacetylase inhibitor, entinostat (ENT), as a pharmacological agent that transcriptionally suppresses the PAX3:FOXO1 tumor-initiating fusion gene found in alveolar rhabdomyosarcoma (aRMS), and we further investigated the mechanism by which ENT suppresses PAX3:FOXO1 oncogene and demonstrated the preclinical efficacy of ENT in RMS orthotopic allograft and patient-derived xenograft (PDX) models. 31113472 2019
Entrez Id: 2308
Gene Symbol: FOXO1
FOXO1
0.100 Biomarker disease BEFREE We re-examined risk stratification by adding FOXO1 status to traditional clinical prognostic factors in children with localized or metastatic RMS. 31456361 2019
Entrez Id: 2308
Gene Symbol: FOXO1
FOXO1
0.100 GeneticVariation disease BEFREE Thus, we examined gene co-expression networks for rhabdomyosarcoma that were <i>FOXO1-PAX3</i> positive, <i>FOXO1-PAX7</i> positive, or fusion negative. 31480361 2019
Entrez Id: 2308
Gene Symbol: FOXO1
FOXO1
0.100 Biomarker disease BEFREE The histological diagnosis was alveolar (RMA) (n = 38, 23/25 examined patients PAX7/3:FOXO1-positive), embryonal (RME) (n = 100), botryoid (n = 10), anaplastic (n = 1), and spindle-cell RMS (n = 6). 30762282 2019
Entrez Id: 2308
Gene Symbol: FOXO1
FOXO1
0.100 Biomarker disease BEFREE While RMS has been traditionally classified on the basis of its histological appearance (with embryonal and alveolar being most common), it is now clear that the PAX-FOXO1 fusion product drives prognosis. 30806137 2019
Entrez Id: 2308
Gene Symbol: FOXO1
FOXO1
0.100 Biomarker disease BEFREE Our findings identify a novel role of both PAX3-FOXO1 and its downstream effector miR-486-5p in exosome-mediated oncogenic paracrine effects of RMS, and suggest its possible use as a biomarker. 31578374 2019
Entrez Id: 2308
Gene Symbol: FOXO1
FOXO1
0.100 GeneticVariation disease BEFREE OLIG2 is a novel immunohistochemical marker associated with the presence of PAX3/7-FOXO1 translocation in rhabdomyosarcomas. 31493794 2019
Entrez Id: 2308
Gene Symbol: FOXO1
FOXO1
0.100 Biomarker disease BEFREE The rapid onset and increased penetrance of tumorigenesis in this model provide a powerful tool for interrogating aRMS biology and screening novel therapeutics.<b>Significance:</b> A novel mouse model sheds light on the critical role of Hippo/MST downregulation in PAX3-FOXO1-positive rhabdomyosarcoma tumorigenesis.<i></i>. 30093562 2018
Entrez Id: 2308
Gene Symbol: FOXO1
FOXO1
0.100 GeneticVariation disease BEFREE Rhabdomyosarcomas (RMSs) are the most frequent soft tissue sarcoma in children and adolescents, defined by skeletal muscle differentiation and the status of FOXO1 fusions. 29898687 2018
Entrez Id: 2308
Gene Symbol: FOXO1
FOXO1
0.100 AlteredExpression disease BEFREE In this article, we review the recent understanding of PAX3-FOXO1 as a transcription factor in the pathogenesis of this cancer and discuss recent developments to target this oncoprotein for treatment of RMS. 30373318 2018
Entrez Id: 2308
Gene Symbol: FOXO1
FOXO1
0.100 Biomarker disease BEFREE Interleukin-24 (IL24) Is Suppressed by PAX3-FOXO1 and Is a Novel Therapy for Rhabdomyosarcoma. 30190424 2018
Entrez Id: 2308
Gene Symbol: FOXO1
FOXO1
0.100 Biomarker disease BEFREE We find that PAX3-FOXO1 establishes a myoblastic super enhancer landscape and creates a profound subtype-unique dependence on BET bromodomains, the inhibition of which ablates PAX3-FOXO1 function, providing a mechanistic rationale for exploring BET inhibitors for patients bearing PAX-fusion rhabdomyosarcoma.<i>Cancer Discov; 7(8); 884-99. 28446439 2017
Entrez Id: 2308
Gene Symbol: FOXO1
FOXO1
0.100 AlteredExpression disease BEFREE In this study, we report overexpression of the nuclear receptor NR4A1 in rhabdomyosarcomas that is sufficient to drive high expression of PAX3-FOXO1A there. 27864345 2017
Entrez Id: 2308
Gene Symbol: FOXO1
FOXO1
0.100 Biomarker disease BEFREE In the present study, we applied fluorescent in situ hybridization (FISH) and found that the Forkhead box O1 (FOXO1) gene broke apart, amplified, and displayed an aneuploid signal that was related to the RMS pathological subtype. 28646473 2017
Entrez Id: 2308
Gene Symbol: FOXO1
FOXO1
0.100 Biomarker disease BEFREE Previous studies, including our own, have shown prognostic value for the presence of PAX3/7-FOXO1 fusion genes in rhabdomyosarcoma (RMS). 28035744 2017
Entrez Id: 2308
Gene Symbol: FOXO1
FOXO1
0.100 Biomarker disease BEFREE Rhabdomyosarcomas (RMS) in children and adolescents are heterogeneous sarcomas broadly defined by skeletal muscle features and the presence/absence of PAX3/7-FOXO1 fusion genes. 27984116 2017
Entrez Id: 2308
Gene Symbol: FOXO1
FOXO1
0.100 Biomarker disease BEFREE Regulatory landscape fusion in rhabdomyosarcoma through interactions between the PAX3 promoter and FOXO1 regulatory elements. 28615069 2017
Entrez Id: 2308
Gene Symbol: FOXO1
FOXO1
0.100 Biomarker disease BEFREE PAX3-FOXO1 is essential for tumour initiation and maintenance but not recurrence in a human myoblast model of rhabdomyosarcoma. 28138962 2017
Entrez Id: 2308
Gene Symbol: FOXO1
FOXO1
0.100 Biomarker disease BEFREE Many findings have demonstrated that PAX/FOXO1-positive ARMS have a worse prognosis than PAX/FOXO1-negative ones and that distinct molecular features characterize RMS with different gene fusion statuses. 28380437 2017
Entrez Id: 2308
Gene Symbol: FOXO1
FOXO1
0.100 Biomarker disease BEFREE The identification of PAX-FOXO1 fusion status in RMS is one of the most important updates in the risk stratification of RMS. 28256213 2017
Entrez Id: 2308
Gene Symbol: FOXO1
FOXO1
0.100 Biomarker disease BEFREE We compared the event-free survival (EFS) and overall survival by histology, PAX-FOXO1 fusion, and clinical risk factors (Oberlin score) for patients with metastatic RMS using the log-rank test. 28521080 2017
Entrez Id: 2308
Gene Symbol: FOXO1
FOXO1
0.100 Biomarker disease BEFREE A clinicopathologic study of head and neck rhabdomyosarcomas showing FOXO1 fusion-positive alveolar and MYOD1-mutant sclerosing are associated with unfavorable outcome. 27688110 2016