Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE In this study, we demonstrate that the small molecule RITA, a p53 activator, effectively downregulates HH signaling in human medulloblastoma and rhabdomyosarcoma cells irrespective of p53. 30447254 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation disease BEFREE In the present study, we show that pharmacological repression by the Hedgehog (Hh) pathway inhibitor (HPI) GANT61 induces expression of the proapoptotic protein Noxa in TP53-mutated embryonal pediatric tumor cells driven by Hh signaling (i.e. rhabdomyosarcoma (RMS) and medulloblastoma (MB)). 29702195 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation disease BEFREE Additional genetic alterations, such as TP53 mutations, were identified in the rhabdomyosarcoma. 28222777 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE Importantly, human double minute 2 inhibitor nutlin-3 decreased RRM1 and RRM2 in TP53 wild type rhabdomyosarcoma Rh18 but not in TP53 mutated Rh30 cells. 28507282 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation disease BEFREE We also demonstrate that miR-605 overexpression leads to a decrease in cell proliferation, clonogenicity, and migration in two rhabdomyosarcoma cell lines carrying hotspot TP53 mutations. 25683625 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE The purpose of the present study was to investigate the role of sirtuin expression, activity and inhibition in the survival of pediatric sarcoma cell lines.We have analyzed the expression of SIRT1 and SIRT2 in a series of pediatric sarcoma tumor cell lines and normal cells, and we have evaluated the activity of the sirtuin inhibitor and p53 activator tenovin-6 (Tv6) in synovial sarcoma and rhabdomyosarcoma cell lines. 25341037 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation disease BEFREE Individuals harboring germline TP53 mutations are predisposed to develop anRMS at a young age. 24382691 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation disease BEFREE Patient 1 with LFS and TP53(R273H) developed a rhabdomyosarcoma twice at the ages of 18 months and 21 years. 21484931 2011
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation disease BEFREE Rhabdomyosarcoma-associated renal cell carcinoma: a link with constitutional Tp53 mutation. 21054160 2011
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 AlteredExpression disease BEFREE The expression of p53 in RMS is heterogeneous such that some tumors are wild-type whereas others are p53 mutant. 20682800 2010
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation disease BEFREE You can win by losing: p53 mutations in rhabdomyosarcomas. 20821751 2010
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE Nutlin-3 effectively restored p53 function in both normal MDM2 expression and MDM2 overexpression RMS cell lines with wild-type p53. p53 restoration therapy is a potential therapeutic strategy for refractory RMS with wild-type p53. 19509161 2009
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE Although a functional HIF-1 pathway and proapoptotic proteins such as p53 and Bcl-2/E1B 19 kDa interacting protein 3 were activated under hypoxia in both A204 RMS and A673 ES cells, these cells remained refractory to apoptosis. 17043658 2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation disease BEFREE Patients with TP53 germline mutations, such as those with Li-Fraumeni syndrome, are particularly susceptible to sarcomas, including rhabdomyosarcomas. 15908567 2006
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE These data demonstrate a novel relationship between MYC and p53-dependent apoptosis, independent of the ability of MYC to induce p53 that may be important in transformed cells other than rhabdomyosarcoma. 17081294 2006
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation disease BEFREE The authors describe a 14-month-old boy who presented with synchronous rhabdomyosarcoma and adrenal cortical carcinoma and a novel mutation of the p53 gene. 16096528 2005
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation disease BEFREE Esophageal carcinosarcoma with basaloid squamous carcinoma and rhabdomyosarcoma components with TP53 mutation. 15482572 2004
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 AlteredExpression disease BEFREE The group of RMS with a worse prognosis (primary tumors and relapses) showed instead p53 overexpression (W&M and mutated), MDR-1 expression and multiploidy, with high 5cEE values and tetraploid peaks. 15015604 2004
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE Rhabdomyosarcoma development in mice lacking Trp53 and Fos: tumor suppression by the Fos protooncogene. 14706339 2003
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation disease BEFREE Pathologically, PPB shares similarities with rhabdomyosarcoma in which p53 mutations arefrequently detected. 11881786 2002
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 AlteredExpression disease BEFREE The different results obtained with these RMS cell lines does not appear to be related to expression of pax3-FKHR, p21, Bax or Bcl-2 but may in part be due to differential regulation of p53 target genes, such as MDM2. 12394275 2002
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 AlteredExpression disease BEFREE In the current study, we demonstrate that transcription of the DRAL gene can be stimulated by p53, since transient expression of functional p53 in rhabdomyosarcoma cells as well as stimulation of endogenous p53 by ionizing radiation in wild-type cells enhances DRAL mRNA levels. 11062252 2000
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE The role of multidrug resistance (MDR) and p53 functional status in the treatment of paediatric rhabdomyosarcoma is unclear. 10917549 2000
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE Loss of alleles and imprinting at 11p15.5 and disruption of genes such as IGF2, ATR, PTC, P16, and TP53 have also been implicated in rhabdomyosarcoma development. 10534762 1999
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation disease BEFREE Rhabdomyosarcoma is associated with chromosomal translocation of t(2:13) in alveolar types, the p53 tumor suppressor gene, and 11p15. 10509467 1999