Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 Biomarker disease BEFREE Human leukocyte antigen (HLA)-DRB1*03 is over-represented in LS, and is associated with a good prognosis, whereas HLA-DRB1*15-positive patients have a more chronic course of sarcoidosis. 30585624 2019
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 Biomarker disease BEFREE Epitopes of native vimentin are antigenic in the group of HLA-DRB1*0301 positive patients with sarcoidosis. 30009963 2018
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 GeneticVariation disease BEFREE Together, these studies reveal the presence of linked <i>in situ</i> recognition of vimentin by both T- and B-cells in HLA-DRB1*03<sup>+</sup> sarcoidosis patients, associated with a selective humoral immune response to the vimentin C-terminus. 30038611 2018
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 GeneticVariation disease BEFREE In the logistic regression models evaluating the association between HLA alleles and chronic sarcoidosis adjusted for rs1049550 and rs2076530, only DRB1*03 was significantly associated with disease resolution. 27662826 2018
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 GeneticVariation disease BEFREE We have previously demonstrated that in our series HLADRB1* 03:01 and haplotype HLA-DRB1*04:01-DPB1*04:01 are associated with good prognosis sarcoidosis. 29229112 2017
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 Biomarker disease BEFREE Results of in silico binding analyses showed that DRB1*03:01 consistently demonstrated the highest binding affinities for six bacterial peptides previously found in sarcoidosis granulomas, whereas *12:01 displayed the lowest binding affinities. 25506722 2015
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 Biomarker disease BEFREE Mechanistic studies of putative sarcoid antigens lend further credence to a role of HLA-DRB1 in disease pathogenesis. 26164297 2015
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 GeneticVariation disease BEFREE The aim of this study was to further investigate associations between HLA-DRB1 alleles and the risk for extra-pulmonary manifestations (EPMs), i.e. engagement of the skin, superficial lymph nodes, eyes, nervous system, kidneys, hypercalcemia, parotid and salivary glands, heart, liver, spleen and bone marrow in Scandinavian sarcoidosis patients. 24641503 2014
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 Biomarker disease BEFREE According to multivariate analysis (MVA), the presence of HLA DRB1*15 was indicated as an independent risk factor for sarcoidosis (OR:2.37; 95% CI: 1.31-4.30, p=0.004). 25078644 2014
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 GeneticVariation disease BEFREE Among sarcoidosis patients, the HLA A*23, A*80, B*08, B*41, DQB1*05 and DRB1*14 antigens tended to be more common than in the controls, whereas the B*44, B*45, B*51, B*58, DRB1*15 and DRB1*16 alleles were more frequently found in control subjects than in the sarcoidosis patients. 23911360 2013
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 Biomarker disease BEFREE Our results support the importance of HLA-DRB1 as a predisposing gene for sarcoidosis. 22074998 2012
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 GeneticVariation disease BEFREE Our studies implicated that the HLA-DRB1 allele is a major contributing genetic factor in the development of sarcoidosis in Japan. 22991420 2012
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 GeneticVariation disease GWASDB Genome-wide association study of African and European Americans implicates multiple shared and ethnic specific loci in sarcoidosis susceptibility. 22952805 2012
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 SusceptibilityMutation disease ORPHANET Genetic characterization and susceptibility for sarcoidosis in Japanese patients: risk factors of BTNL2 gene polymorphisms and HLA class II alleles. 22991420 2012
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 GeneticVariation disease BEFREE BTNL2 rs206530 A allele frequencies were significantly higher in sarcoidosis with no linkage disequilibrium with HLA-DRB1 alleles, except in the subgroup of patients with Löfgren syndrome where the determinant allele was HLA-DRB1*03. 23017494 2012
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 GeneticVariation disease BEFREE These results support the hypothesis that HLA-A, -B, and -DRB1 polymorphisms may play a role in susceptibility and manifestation of sarcoidosis. 21513758 2011
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 Biomarker disease BEFREE HLA-DRB1*04 seems to protect against overall sarcoidosis but appears to be a significant risk factor for ocular sarcoidosis as well as for other manifestations associated with HS. 21565911 2011
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 Biomarker disease BEFREE In the group of patients with chronic sarcoidosis DRB1*11 (P=0.0219; OR=2.44), DRB1*15 (P=0.0414; OR=2.47) demonstrated statistically significant difference in comparison to controls only, while a lower frequency of DRB1*13 (P=0.0156; OR=0.24) in this group was statistically significant when compared to both patients with acute sarcoidosis and controls. 21796887 2011
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 GeneticVariation disease BEFREE Löfgren's syndrome is a common sarcoidosis phenotype in the Dutch and is strongly associated with the DRB1*0301 allele. 20685690 2010
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 GeneticVariation disease BEFREE Different HLA-DRB1 allele distributions in distinct clinical subgroups of sarcoidosis patients. 20187937 2010
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 GeneticVariation disease BEFREE In a retrospective case-control study, TNF-alpha G-308A, TNF-alpha G-238A, lymphotoxin-alpha (LTA) and HLA-DRB1*03 were genotyped in 625 sarcoidosis patients. 20070603 2010
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 Biomarker disease BEFREE ESAT-6 and katG presented by antigen-presenting cells expressing DRB1*1101-induced Th-1 responses from sarcoidosis T cells, thus providing a mechanistic insight for the association of HLA DRB1*1101 with sarcoidosis, and sarcoidosis T cell interaction with microbial antigens. 19536643 2010
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 Biomarker disease BEFREE In addition, HLA DRB1*1101 and insecticide exposure at work was associated with extrapulmonary sarcoidosis, specifically cardiac sarcoidosis and hypercalcemia (p<0.05) and HLA DRB1*1101 and exposure to molds and musty odors was associated with pulmonary only sarcoidosis (P < 0.05). 19382531 2008
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 Biomarker disease BEFREE Finally, multivariate analysis revealed that the CCR2 association was independent of HLA-DRB1*0301 in both Spanish (P = 0.02 vs. controls) and Swedish cohorts (P = 0.002 vs. non-Löfgren sarcoidosis, P = 0.001 vs. controls). 18513341 2008
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 GeneticVariation disease BEFREE Initially, we studied the association of sarcoidosis with DQB1, and in the present study, we evaluated all amino acid variants of the HLA-DPB1, -DQB1, -DRB1, -DRB3, -DRB4 and -DRB5 genes to identify possible polymorphisms associated with the disease. 17559577 2007