Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.400 Biomarker disease BEFREE Interleukin-18 (IL-18) has been strongly implicated in the pathogenesis of sarcoidosis. 27063085 2016
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.400 GeneticVariation disease BEFREE As genetic factors have been implicated in its aetiology, in our study we investigated whether the promotor polymorphisms in three genes coding for inflammatory mediators interleukin-6 (IL-6), interleukin-12 (IL-12), and interleukin-18 (IL-18) could be associated with susceptibility to sarcoidosis. 17671745 2007
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.400 AlteredExpression disease BEFREE In situ hybridization revealed different sites of expression in tuberculosis and sarcoidosis lungs, with AEC-II as one major source of IL-18 in the alveolar compartment. 16420594 2006
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.400 AlteredExpression disease LHGDN "Interleukin-18-607 promoter polymorphism in sarcoidosis: ignoring ""negative"" results." 16556702 2006
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.400 AlteredExpression disease LHGDN Interleukin-18 expression by alveolar epithelial cells type II in tuberculosis and sarcoidosis. 16420594 2006
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.400 Biomarker disease CTD_human Epithelial lining fluid from active sarcoids contained elevated levels of interleukin-18, interferon-gamma, and interleukin-12 compared with recovered patients and also contained significantly higher levels of endotoxin. 16100009 2005
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.400 GeneticVariation disease BEFREE However, -607 C/A and -656 G/T were significantly associated with serum levels of IL-18 in patients with sarcoidosis, but not in controls. 16053025 2005
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.400 GeneticVariation disease LHGDN Roles of functional polymorphisms in the interleukin-18 gene promoter in sarcoidosis. 16053025 2005
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.400 AlteredExpression disease BEFREE Expression of IL-18 and tumour necrosis factor-alpha (TNFalpha) mRNA in cells of the BAL of 23 patients with sarcoidosis and nine healthy volunteers was determined using semiquantitative RT-PCR. 12735669 2003
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.400 GeneticVariation disease LHGDN Association of single nucleotide polymorphisms in the IL-18 gene with sarcoidosis in a Japanese population. 12366781 2002
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.400 GeneticVariation disease BEFREE In IL-18 gene polymorphisms, the C allele at position -607 might be a genetic risk factor for sarcoidosis in this Japanese population. 12366781 2002
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.400 AlteredExpression disease BEFREE IL-18 mRNA expression was observed in freshly isolated sarcoid BAL fluid cells as well as in LPS-stimulated sarcoid BAL fluid cells, but IFN-gamma and IL-12 mRNA expression was observed only in LPS-stimulated BAL fluid cells. 11123348 2001
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.400 Biomarker disease BEFREE Our results coupled with those of previous investigations demonstrating activity of IL-18 in inducing interferon-gamma production suggest a significant role of IL-18 in the pathogenesis of sarcoidosis. 11580222 2001
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.400 AlteredExpression disease BEFREE We investigated the role of IL-18 in IL-2 expression in sarcoidosis. 11035116 2000
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.400 AlteredExpression disease BEFREE Similarly, constitutive expression of IL-18 protein was observed within the airway epithelium of control individuals, with more positive cells found within sarcoidosis tissue (p<0.01) and fewer within asthmatic tissue (p<0.01), compared to controls. 10543274 1999