Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 56244
Gene Symbol: BTNL2
BTNL2
0.700 GeneticVariation disease BEFREE BTNL2 gene G16071A SNP seems to be a predisposing factor for sarcoidosis except in Caucasian postmenopausal women with sarcoid uveitis in whom the GG genotype prevails. 30872286 2019
Entrez Id: 56244
Gene Symbol: BTNL2
BTNL2
0.700 GeneticVariation disease BEFREE We analyzed associations between sarcoidosis clinical course and HLA class I/II alleles and susceptibility gene SNPs ANXA11 rs1049550 C/T and BTNL2 rs2076530 G/A in a Portuguese population, investigating possible gene-gene interactions. 27662826 2018
Entrez Id: 56244
Gene Symbol: BTNL2
BTNL2
0.700 GeneticVariation disease BEFREE The sarcoidosis risk variant rs2076530 in BTNL2 was associated with all OFG (P = 0.013). 27306066 2016
Entrez Id: 56244
Gene Symbol: BTNL2
BTNL2
0.700 GeneticVariation disease BEFREE The meta-analysis indicated that BTNL2 G16071A gene polymorphism may as a likelihood factor contributed to granulomatous disease susceptibility, especially increasing the sarcoidosis susceptibility. 27472712 2016
Entrez Id: 56244
Gene Symbol: BTNL2
BTNL2
0.700 GeneticVariation disease BEFREE This meta-analysis indicates that BTNL2 rs2076530 polymorphism contributes to the risk of sarcoidosis. 25849037 2015
Entrez Id: 56244
Gene Symbol: BTNL2
BTNL2
0.700 GeneticVariation disease BEFREE These results confirm the association of BTNL2 rs2076530SNP with the susceptibility to develop sarcoidosis, but not with an increased risk of cancer in these patients. 25078641 2014
Entrez Id: 56244
Gene Symbol: BTNL2
BTNL2
0.700 GeneticVariation disease GWASCAT Genome-wide association analysis reveals 12q13.3-q14.1 as new risk locus for sarcoidosis. 22936702 2013
Entrez Id: 56244
Gene Symbol: BTNL2
BTNL2
0.700 GeneticVariation disease BEFREE Both BTNL2 SNPs were associated with risk of sarcoidosis in separate models, but in a combined analysis the increased risk was due to the A-allele of the rs3817963 SNP; each copy of the A-allele was associated with a 40 % increase in risk of sarcoidosis (p = 0.02) and was confirmed by our haplotypic analysis. 23543185 2013
Entrez Id: 56244
Gene Symbol: BTNL2
BTNL2
0.700 GeneticVariation disease GWASDB Genome-wide association analysis reveals 12q13.3-q14.1 as new risk locus for sarcoidosis. 22936702 2013
Entrez Id: 56244
Gene Symbol: BTNL2
BTNL2
0.700 GeneticVariation disease BEFREE Our data confirms the association of BTNL2 rs2076530 A allele with sarcoidosis susceptibility in a Portuguese population. 23017494 2012
Entrez Id: 56244
Gene Symbol: BTNL2
BTNL2
0.700 GeneticVariation disease GWASDB Genome-wide association study of African and European Americans implicates multiple shared and ethnic specific loci in sarcoidosis susceptibility. 22952805 2012
Entrez Id: 56244
Gene Symbol: BTNL2
BTNL2
0.700 GeneticVariation disease BEFREE The purpose of our study was to verify the relationship between BTNL2 and HLA risk alleles for the susceptibility to sarcoidosis, and to assess whether the BTNL2 association is independent of the HLA risk alleles. 22991420 2012
Entrez Id: 56244
Gene Symbol: BTNL2
BTNL2
0.700 GeneticVariation disease BEFREE Furthermore, BTNL2 16071A variant allele carriers have an increased risk (OR = 1.85, 95% CI 1.19-2.88) of developing sarcoidosis. 21256912 2011
Entrez Id: 56244
Gene Symbol: BTNL2
BTNL2
0.700 GeneticVariation disease BEFREE An association has been reported between sarcoidosis and a single nucleotide polymorphism in BTNL2, rs2076530, also termed the A allele. 21410903 2011
Entrez Id: 56244
Gene Symbol: BTNL2
BTNL2
0.700 Biomarker disease LHGDN The CNV_ID 507, which was highlighted for its possible involvement in sarcoidosis because of its partly deletion of the BTNL2 gene, was tested for association in a cohort of 89 sarcoidosis patients and 89 matched controls, but our results indicated that CNV_ID 507 does not affect the genomic structure of BTLN2 as previously described. 19140834 2009
Entrez Id: 56244
Gene Symbol: BTNL2
BTNL2
0.700 GeneticVariation disease BEFREE The CNV_ID 507, which was highlighted for its possible involvement in sarcoidosis because of its partly deletion of the BTNL2 gene, was tested for association in a cohort of 89 sarcoidosis patients and 89 matched controls, but our results indicated that CNV_ID 507 does not affect the genomic structure of BTLN2 as previously described. 19140834 2009
Entrez Id: 56244
Gene Symbol: BTNL2
BTNL2
0.700 Biomarker disease BEFREE Our data suggest that the absence of a membrane anchored BTNL2 protein may increase genetic susceptibility to sarcoidosis and familial occurrence of the disease. 20560297 2009
Entrez Id: 56244
Gene Symbol: BTNL2
BTNL2
0.700 GeneticVariation disease BEFREE Butyrophilin-like 2 (BTNL2) is a butyrophilin family member with homology to the B7 costimulatory molecules, polymorphisms of which have been recently associated through genetic analyses to sporadic inclusion body myositis and sarcoidosis. 17237401 2007
Entrez Id: 56244
Gene Symbol: BTNL2
BTNL2
0.700 GeneticVariation disease BEFREE Genome-wide screening has conclusively identified linkage to chromosome 5q11and the development of sarcoidosis, and HLA genes and BTNL2 are susceptibility genes located in this region. 18037811 2007
Entrez Id: 56244
Gene Symbol: BTNL2
BTNL2
0.700 GeneticVariation disease BEFREE Follow-up studies on chromosome 6 identified the BTNL2 gene, a B7 family costimulatory molecule to be associated with sarcoidosis. 17330189 2007
Entrez Id: 56244
Gene Symbol: BTNL2
BTNL2
0.700 GeneticVariation disease BEFREE A recent study of sarcoidosis has provided evidence of an independent effect, associated with a truncating single nucleotide polymorphism (SNP) of a nearby gene, BTNL2. 17493147 2007
Entrez Id: 56244
Gene Symbol: BTNL2
BTNL2
0.700 GeneticVariation disease BEFREE The RAGE coding gene maps to the 6p21.32 region, close to the genes DRB1 and BTNL2, which are associated with sarcoidosis. 17170388 2007
Entrez Id: 56244
Gene Symbol: BTNL2
BTNL2
0.700 GeneticVariation disease BEFREE BTNL2 haplotype 4, tagged by the rs2076530 G allele, also remained associated with non-Löfgren sarcoidosis after adjusting for HLA-DRB1 alleles (OR 0.37, P = 0.016). 17661910 2007
Entrez Id: 56244
Gene Symbol: BTNL2
BTNL2
0.700 GeneticVariation disease BEFREE Recently, an association between sarcoidosis and the butyrophilin-like 2 (BTNL2) gene was reported. 17610417 2007
Entrez Id: 56244
Gene Symbol: BTNL2
BTNL2
0.700 AlteredExpression disease BEFREE The bacterium Mycobacterium tuberculosis can induce the expression of the sarcoidosis susceptibility gene BTNL2 in monocyte-derived macrophages. 17347014 2007