Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.500 GeneticVariation disease GWASCAT Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia. 28540026 2017
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.500 GeneticVariation disease BEFREE While we have failed to confirm association of the candidate alleles in the DRB1 gene with a high risk of schizophrenia, the present work suggests that the association signal detected in the HLA class II locus may extend a relatively long distance, and more work is needed in order to identify the true causal variants within this region or nearby. 23053058 2013
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.500 GeneticVariation disease BEFREE These convergent findings from genetics and epidemiology imply that a subset of autism and schizophrenia cases may be underlain by genetically based neuroimmune alterations, and that analyses of the causes of risk and protective effects from DRB1 variants may provide new approaches to therapy. 21649858 2011
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.500 GeneticVariation disease BEFREE However it is not clear whether the DRB1*03 alleles have a direct causal role in the etiology of schizophrenia or if they are in direct linkage disequilibrium with another true susceptibility locus. 22121859 2011
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.500 Biomarker disease BEFREE Here, we report the results of a family-based candidate-gene study that brings together these two disparate lines of research by assessing maternal-fetal genotype matching at HLA-A, -B, and -DRB1 as a risk factor of schizophrenia. 16960807 2006
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.500 Biomarker disease BEFREE Implementing this systematic approach, we: (i) discovered 177 putative SZ risk genes in brain, 28 of which map to linked chromosomal loci; (ii) delineated six biological processes and 12 molecular functions that may be particularly disrupted in the illness; (iii) identified 123 putative SZ biomarkers in blood, 6 of which (BTG1, GSK3A, HLA-DRB1, HNRPA3, SELENBP1, and SFRS1) had corresponding differential expression in brain; (iv) verified the differential expression of the strongest candidate SZ biomarker (SELENBP1) in blood; and (v) demonstrated neuronal and glial expression of SELENBP1 protein in brain. 16223876 2005
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.500 Biomarker disease CTD_human Implementing this systematic approach, we: (i) discovered 177 putative SZ risk genes in brain, 28 of which map to linked chromosomal loci; (ii) delineated six biological processes and 12 molecular functions that may be particularly disrupted in the illness; (iii) identified 123 putative SZ biomarkers in blood, 6 of which (BTG1, GSK3A, HLA-DRB1, HNRPA3, SELENBP1, and SFRS1) had corresponding differential expression in brain; (iv) verified the differential expression of the strongest candidate SZ biomarker (SELENBP1) in blood; and (v) demonstrated neuronal and glial expression of SELENBP1 protein in brain. 16223876 2005
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.500 GeneticVariation disease BEFREE Investigation of linkage and association/linkage disequilibrium of HLA A-, DQA1-, DQB1-, and DRB1-alleles in 69 sib-pair- and 89 trio-families with schizophrenia. 11920855 2002
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.500 Biomarker disease BEFREE Hypothesis-driven negative associations of DRB1*04 and DQB1*0602 with schizophrenia have also been reported. 11163540 2001
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.500 GeneticVariation disease BEFREE The frequency of DRB1(*)01, DRB1(*)08, DRB1(*)10, DRB1(*)11, and DRB1(*)15 alleles was almost identical in schizophrenia patients and controls. 11121200 2000
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.500 GeneticVariation disease BEFREE A larger proportion of the patients with schizophrenia (15.9%) than the comparison subjects (10.5%) were found to have DR1 (DRB1*0101). 10327913 1999
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.500 GeneticVariation disease BEFREE The results from this small sample need to be interpreted with caution, but they are in keeping with previous reports and suggest that HLA DRB1*04 alleles may be associated with a reduced risk of schizophrenia. 9713901 1998
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.500 GeneticVariation disease BEFREE Thus, these findings support an association of the HLA DRB1 gene locus with schizophrenia in the Japanese population. 9713902 1998
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.500 GeneticVariation disease BEFREE DRB1*04 alleles may partially account for the genetic predisposition to schizophrenia. 8942447 1996