HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia.
|
28540026 |
2017 |
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
While we have failed to confirm association of the candidate alleles in the DRB1 gene with a high risk of schizophrenia, the present work suggests that the association signal detected in the HLA class II locus may extend a relatively long distance, and more work is needed in order to identify the true causal variants within this region or nearby.
|
23053058 |
2013 |
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These convergent findings from genetics and epidemiology imply that a subset of autism and schizophrenia cases may be underlain by genetically based neuroimmune alterations, and that analyses of the causes of risk and protective effects from DRB1 variants may provide new approaches to therapy.
|
21649858 |
2011 |
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
However it is not clear whether the DRB1*03 alleles have a direct causal role in the etiology of schizophrenia or if they are in direct linkage disequilibrium with another true susceptibility locus.
|
22121859 |
2011 |
HLA-DRB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
Here, we report the results of a family-based candidate-gene study that brings together these two disparate lines of research by assessing maternal-fetal genotype matching at HLA-A, -B, and -DRB1 as a risk factor of schizophrenia.
|
16960807 |
2006 |
HLA-DRB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
Implementing this systematic approach, we: (i) discovered 177 putative SZ risk genes in brain, 28 of which map to linked chromosomal loci; (ii) delineated six biological processes and 12 molecular functions that may be particularly disrupted in the illness; (iii) identified 123 putative SZ biomarkers in blood, 6 of which (BTG1, GSK3A, HLA-DRB1, HNRPA3, SELENBP1, and SFRS1) had corresponding differential expression in brain; (iv) verified the differential expression of the strongest candidate SZ biomarker (SELENBP1) in blood; and (v) demonstrated neuronal and glial expression of SELENBP1 protein in brain.
|
16223876 |
2005 |
HLA-DRB1
|
0.500 |
Biomarker
|
disease |
CTD_human |
Implementing this systematic approach, we: (i) discovered 177 putative SZ risk genes in brain, 28 of which map to linked chromosomal loci; (ii) delineated six biological processes and 12 molecular functions that may be particularly disrupted in the illness; (iii) identified 123 putative SZ biomarkers in blood, 6 of which (BTG1, GSK3A, HLA-DRB1, HNRPA3, SELENBP1, and SFRS1) had corresponding differential expression in brain; (iv) verified the differential expression of the strongest candidate SZ biomarker (SELENBP1) in blood; and (v) demonstrated neuronal and glial expression of SELENBP1 protein in brain.
|
16223876 |
2005 |
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Investigation of linkage and association/linkage disequilibrium of HLA A-, DQA1-, DQB1-, and DRB1-alleles in 69 sib-pair- and 89 trio-families with schizophrenia.
|
11920855 |
2002 |
HLA-DRB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
Hypothesis-driven negative associations of DRB1*04 and DQB1*0602 with schizophrenia have also been reported.
|
11163540 |
2001 |
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The frequency of DRB1(*)01, DRB1(*)08, DRB1(*)10, DRB1(*)11, and DRB1(*)15 alleles was almost identical in schizophrenia patients and controls.
|
11121200 |
2000 |
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A larger proportion of the patients with schizophrenia (15.9%) than the comparison subjects (10.5%) were found to have DR1 (DRB1*0101).
|
10327913 |
1999 |
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The results from this small sample need to be interpreted with caution, but they are in keeping with previous reports and suggest that HLA DRB1*04 alleles may be associated with a reduced risk of schizophrenia.
|
9713901 |
1998 |
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Thus, these findings support an association of the HLA DRB1 gene locus with schizophrenia in the Japanese population.
|
9713902 |
1998 |
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
DRB1*04 alleles may partially account for the genetic predisposition to schizophrenia.
|
8942447 |
1996 |