Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 63826
Gene Symbol: SRR
SRR
0.700 Biomarker disease BEFREE Our findings thus demonstrate neuronal SR association with DISC1 and its agglomerates, which can be modulated by d-Serine, thereby validating a novel neuronal SR-DISC1 complex responsive to NMDAR activation and providing a molecular mechanism by which pathways implicated in schizophrenia converge. 30391323 2019
Entrez Id: 63826
Gene Symbol: SRR
SRR
0.700 GeneticVariation disease GWASCAT Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect. 30285260 2019
Entrez Id: 63826
Gene Symbol: SRR
SRR
0.700 Biomarker disease BEFREE Serine racemase knockout mice demonstrate abnormalities in socio-communicative behaviors consistent with an impairment in sociality, a negative symptom of schizophrenia. 31515952 2019
Entrez Id: 63826
Gene Symbol: SRR
SRR
0.700 AlteredExpression disease BEFREE The enzymes involved in its formation and catabolism are serine racemase (SR) and D-amino acid oxidase (DAAO), respectively, and manipulations of the activity of those enzymes have been useful in developing animal models of schizophrenia and in providing clues to the development of potential new antipsychotic strategies. 30787885 2019
Entrez Id: 63826
Gene Symbol: SRR
SRR
0.700 GeneticVariation disease BEFREE We used transgenic mice with a null mutation of the gene encoding serine racemase (SR), the enzyme that synthesizes the NMDAR co-agonist d-serine and an established risk gene for SZ, to recreate the pathology of SZ. 29168271 2019
Entrez Id: 63826
Gene Symbol: SRR
SRR
0.700 GeneticVariation disease GWASCAT Association of Schizophrenia Risk With Disordered Niacin Metabolism in an Indian Genome-wide Association Study. 31268507 2019
Entrez Id: 63826
Gene Symbol: SRR
SRR
0.700 Biomarker disease BEFREE Nowadays, SR deregulation is associated with a wide range of neurological and psychiatric diseases including schizophrenia, amyotrophic lateral sclerosis, and depression. 30555832 2018
Entrez Id: 63826
Gene Symbol: SRR
SRR
0.700 GeneticVariation disease GWASCAT Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia. 28540026 2017
Entrez Id: 63826
Gene Symbol: SRR
SRR
0.700 Biomarker disease BEFREE Inactivation of one of these risk genes that encodes serine racemase, which synthesizes D-serine, an NMDAR co-agonist, reproduces the synaptic pathology of schizophrenia. 26954593 2016
Entrez Id: 63826
Gene Symbol: SRR
SRR
0.700 GeneticVariation disease GWASCAT Genome-wide association study of schizophrenia in Ashkenazi Jews. 26198764 2015
Entrez Id: 63826
Gene Symbol: SRR
SRR
0.700 GeneticVariation disease GWASCAT Biological insights from 108 schizophrenia-associated genetic loci. 25056061 2014
Entrez Id: 63826
Gene Symbol: SRR
SRR
0.700 GeneticVariation disease GWASCAT Genome-wide association analysis identifies 13 new risk loci for schizophrenia. 23974872 2013
Entrez Id: 63826
Gene Symbol: SRR
SRR
0.700 GeneticVariation disease GWASDB Genome-wide association analysis identifies 13 new risk loci for schizophrenia. 23974872 2013
Entrez Id: 63826
Gene Symbol: SRR
SRR
0.700 Biomarker disease PSYGENET Pathogenic disruption of DISC1-serine racemase binding elicits schizophrenia-like behavior via D-serine depletion. 22801410 2013
Entrez Id: 63826
Gene Symbol: SRR
SRR
0.700 GeneticVariation disease BEFREE Multiple risk pathways for schizophrenia converge in serine racemase knockout mice, a mouse model of NMDA receptor hypofunction. 23729812 2013
Entrez Id: 63826
Gene Symbol: SRR
SRR
0.700 Biomarker disease BEFREE Pathogenic disruption of DISC1-serine racemase binding elicits schizophrenia-like behavior via D-serine depletion. 22801410 2013
Entrez Id: 63826
Gene Symbol: SRR
SRR
0.700 Biomarker disease BEFREE This study demonstrates that aberrant Srr function and diminished d-serine may contribute to schizophrenia pathogenesis. 19483194 2009
Entrez Id: 63826
Gene Symbol: SRR
SRR
0.700 Biomarker disease PSYGENET This study demonstrates that aberrant Srr function and diminished d-serine may contribute to schizophrenia pathogenesis. 19483194 2009
Entrez Id: 63826
Gene Symbol: SRR
SRR
0.700 Biomarker disease MGD This study demonstrates that aberrant Srr function and diminished d-serine may contribute to schizophrenia pathogenesis. 19483194 2009
Entrez Id: 63826
Gene Symbol: SRR
SRR
0.700 Biomarker disease MGD Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior. 19065142 2009
Entrez Id: 63826
Gene Symbol: SRR
SRR
0.700 Biomarker disease PSYGENET The IVS1a+465C allele of the SRR gene, which reduces expression of the gene, is a risk factor for schizophrenia, especially the paranoid subtype. 17067558 2007
Entrez Id: 63826
Gene Symbol: SRR
SRR
0.700 AlteredExpression disease LHGDN These findings establish the major cell types wherein serine racemase and D-amino acid oxidase are expressed in human brain and provide some support for aberrant D-serine metabolism in schizophrenia. 17880399 2007
Entrez Id: 63826
Gene Symbol: SRR
SRR
0.700 GeneticVariation disease BEFREE The IVS1a+465C allele of the SRR gene, which reduces expression of the gene, is a risk factor for schizophrenia, especially the paranoid subtype. 17067558 2007
Entrez Id: 63826
Gene Symbol: SRR
SRR
0.700 Biomarker disease BEFREE Serine racemase binds to PICK1: potential relevance to schizophrenia. 16314870 2006
Entrez Id: 63826
Gene Symbol: SRR
SRR
0.700 AlteredExpression disease LHGDN We studied the expression of serine racemase, an astrocytic enzyme which synthesizes the N-methyl-D-aspartate receptor coagonist D-serine, using Western blot analysis in postmortem hippocampus and cortex in schizophrenia and a comparison group. 16837850 2006