Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 64478
Gene Symbol: CSMD1
CSMD1
0.700 Biomarker disease BEFREE To better elucidate the additive effects of multiple complement genotypes, we also conducted gene- and gene-set analysis through MAGMA which supported the role of Human Leukocyte Antigen class (HLA) III genes and, to a lesser extent, CSMD1 in schizophrenia; however, the HLA-schizophrenia association was likely driven by the C4 gene. 31439935 2020
Entrez Id: 64478
Gene Symbol: CSMD1
CSMD1
0.700 GeneticVariation disease GWASCAT Association of Schizophrenia Risk With Disordered Niacin Metabolism in an Indian Genome-wide Association Study. 31268507 2019
Entrez Id: 64478
Gene Symbol: CSMD1
CSMD1
0.700 Biomarker disease BEFREE Our results showed that the expression levels of CSMD1 are correlated with the development and treatment of SCZ, providing further evidence for the involvement of CSMD1 in SCZ. 30987620 2019
Entrez Id: 64478
Gene Symbol: CSMD1
CSMD1
0.700 GeneticVariation disease GWASCAT Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect. 30285260 2019
Entrez Id: 64478
Gene Symbol: CSMD1
CSMD1
0.700 GeneticVariation disease BEFREE Particularly, GM reduction in thalamus, putamen and bilateral temporal gyrus in schizophrenia was associated with fALFF decrease in medial prefrontal cortex, both were also associated with genetic factors enriched in neuron development, synapse organization and axon pathways, highlighting genes including CSMD1, CNTNAP2, DCC, GABBR2 etc. 30341038 2018
Entrez Id: 64478
Gene Symbol: CSMD1
CSMD1
0.700 GeneticVariation disease GWASCAT Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection. 29483656 2018
Entrez Id: 64478
Gene Symbol: CSMD1
CSMD1
0.700 Biomarker disease BEFREE Gene-based tests highlighted 20 additional genes of which 5 had previously been associated to schizophrenia and/or bipolar disorder: CSMD1, CCDC141, SLC1A2, CACNA1C, and SNAP25. 28525603 2017
Entrez Id: 64478
Gene Symbol: CSMD1
CSMD1
0.700 GeneticVariation disease BEFREE An intronic SNP within CSMD1, rs10503253, is one of the top risk SNPs for schizophrenia in Europeans discovered through large GWAS. 28344127 2017
Entrez Id: 64478
Gene Symbol: CSMD1
CSMD1
0.700 GeneticVariation disease GWASCAT Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia. 28991256 2017
Entrez Id: 64478
Gene Symbol: CSMD1
CSMD1
0.700 GeneticVariation disease BEFREE Genetic variants in the closely related CSMD1 and CSMD2 genes, which are implicated in complement regulation, are associated with schizophrenia. 27890662 2017
Entrez Id: 64478
Gene Symbol: CSMD1
CSMD1
0.700 GeneticVariation disease BEFREE An intergenic SNP (rs183854424) 14 kb downstream of CSMD1, which is implicated in schizophrenia, showed suggestive evidence of association in the WM FA meta-analysis (meta P value = 1.43 × 10<sup>-07</sup>) and the multimodal analysis (Fisher P value = 1 × 10<sup>-07</sup>). 26852023 2016
Entrez Id: 64478
Gene Symbol: CSMD1
CSMD1
0.700 GeneticVariation disease BEFREE Our findings do not support an association between CSMD1 rs10503253 and SCZ in a Han Chinese population. 27377754 2016
Entrez Id: 64478
Gene Symbol: CSMD1
CSMD1
0.700 GeneticVariation disease BEFREE A CSMD1 intron 3 SNP displays p < 10-8 association with schizophrenia and more modest associations with individual differences in performance on tests of cognitive abilities. 26171607 2015
Entrez Id: 64478
Gene Symbol: CSMD1
CSMD1
0.700 GeneticVariation disease GWASCAT Genome-wide association study of schizophrenia in Ashkenazi Jews. 26198764 2015
Entrez Id: 64478
Gene Symbol: CSMD1
CSMD1
0.700 Biomarker disease PSYGENET These results underline the relevance of the risk "A" allele to neurocognitive functioning and suggest that its detrimental effects on cognition, may be part of the mechanism by which the CSMD1 mediates risk for schizophrenia. 24630139 2014
Entrez Id: 64478
Gene Symbol: CSMD1
CSMD1
0.700 Biomarker disease BEFREE These results underline the relevance of the risk "A" allele to neurocognitive functioning and suggest that its detrimental effects on cognition, may be part of the mechanism by which the CSMD1 mediates risk for schizophrenia. 24630139 2014
Entrez Id: 64478
Gene Symbol: CSMD1
CSMD1
0.700 Biomarker disease PSYGENET A post hoc analysis of loci significantly associated with psychiatric disorders suggested that genetic variation at CSMD1, a schizophrenia susceptibility locus, plays a role in the ratio between dopamine and serotonin metabolites in CSF. 23319000 2014
Entrez Id: 64478
Gene Symbol: CSMD1
CSMD1
0.700 GeneticVariation disease BEFREE A post hoc analysis of loci significantly associated with psychiatric disorders suggested that genetic variation at CSMD1, a schizophrenia susceptibility locus, plays a role in the ratio between dopamine and serotonin metabolites in CSF. 23319000 2014
Entrez Id: 64478
Gene Symbol: CSMD1
CSMD1
0.700 Biomarker disease PSYGENET In particular, our two-stage strategy found association in both our combined case/control analysis and the family-based analysis on 1q21.2 (closest gene: sphingosine-1-phosphate receptor 1 gene, S1PR1) and on 1q24.1 near the gene TMCO1, and at CSMD1 on 8p23.2, supporting several previous GWAS reports for BD and for schizophrenia. 24387768 2014
Entrez Id: 64478
Gene Symbol: CSMD1
CSMD1
0.700 GeneticVariation disease GWASCAT Biological insights from 108 schizophrenia-associated genetic loci. 25056061 2014
Entrez Id: 64478
Gene Symbol: CSMD1
CSMD1
0.700 Biomarker disease PSYGENET In accordance with previous evidence, these data suggest that CSMD1 may mediate brain function related to cognitive processes (i.e., executive function); with the relatively deleterious effects of the identified "A" risk allele on brain activity possibly constituting part of the mechanism by which CSMD1 increases schizophrenia risk. 23839771 2013
Entrez Id: 64478
Gene Symbol: CSMD1
CSMD1
0.700 GeneticVariation disease GWASCAT GWAS meta analysis identifies TSNARE1 as a novel Schizophrenia / Bipolar susceptibility locus. 24166486 2013
Entrez Id: 64478
Gene Symbol: CSMD1
CSMD1
0.700 Biomarker disease PSYGENET Neuropsychological deficits in mice depleted of the schizophrenia susceptibility gene CSMD1. 24244513 2013
Entrez Id: 64478
Gene Symbol: CSMD1
CSMD1
0.700 Biomarker disease BEFREE Consistent with previous evidence suggesting that CSMD1 may be involved in brain mechanisms related to memory and learning, these data appear to reflect the deleterious effects of the identified 'A' risk allele on neurocognitive function, possibly as part of the mechanism by which CSMD1 is associated with SZ risk. 23320435 2013
Entrez Id: 64478
Gene Symbol: CSMD1
CSMD1
0.700 GeneticVariation disease GWASCAT Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. 23453885 2013