Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.400 GeneticVariation disease BEFREE Polymorphisms in exons 2-4 for HLA-A, -B, -C loci, exon 2 for HLA-DRB1 and exons 2,3 for HLA-DQB1 were analyzed for association with PSS at allele and haplotype levels. 26161794 2015
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.400 Biomarker disease BEFREE Association of HLA-DQB1*0501 with scleroderma and its clinical features in Chinese population. 24067471 2014
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.400 GeneticVariation disease BEFREE Although many studies have analyzed HLA allele frequencies in several ethnic groups in patients with scleroderma (SSc), none has been done in French Caucasian patients and none has evaluated which one of the common amino acid sequences, (67)FLEDR(71), shared by HLA-DRB susceptibility alleles, or (71)TRAELDT(77), shared by HLA-DQB1 susceptibility alleles in SSc, was the most important to develop the disease. 22615829 2012
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.400 GeneticVariation disease BEFREE Within the HLA region, HLA-DQB1, HLA-DPA1/B1, and NOTCH4 associations with SSc are likely confined to specific auto-antibodies. 21779181 2011
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.400 Biomarker disease CTD_human Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus. 20383147 2010
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.400 GeneticVariation disease BEFREE To examine the role of HLA-DRB1 and HLA-DQB1 alleles in the susceptibility to systemic sclerosis (SSc) and its clinical expression in a Spanish population. 19884273 2009
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.400 Biomarker disease BEFREE HLA-DQB1*0301 was significantly associated with SSc per se in all 3 ethnic groups; HLA-DRB1*11 correlated with the anti-topoisomerase I antibody response, and HLA-DRB1*01, DRB1*04, and DQB1*0501 with ACA. 11303306 2001
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.400 GeneticVariation disease BEFREE Antifibrillarin, although an infrequent nucleolar autoantibody, is a marker for severe SSc, especially in blacks and males, and is strongly associated with a unique HLA haplotype, as well as with combinations of certain HLA-DQB1 alleles. 8670324 1996
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.400 GeneticVariation disease BEFREE Position 26 of the first domain of the HLA-DQB1 allele in post-silicone implant scleroderma. 8991984 1995
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.400 Biomarker disease BEFREE HLA class II typing for HLA-DRB1 and HLA-DQB1 was performed by oligonucleotide typing in 49 families.Six probands and two relatives had ATA.The relatives with ATA had SSc. 7980852 1994
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.400 GeneticVariation disease BEFREE The increase in DRB1*1502-DRB5*0102 haplotype supported the hypothesis of Reveille, et al that uncharged polar amino acid residue at position 30 of HLA-DQB1 allele was important for a-Scl-70 positive PSS because close association of the haplotype with DQB1*0601 was well established in Japanese; listed as a hypothetical candidate of PSS susceptible DQB1 allele. 8064726 1994
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.400 Biomarker disease BEFREE The development of an anticentromere antibody response in patients with systemic sclerosis appears to require the presence of a polar amino acid at position 26 in the antigen-binding cleft of the HLA-DQB1 molecule. 1457282 1992
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.400 GeneticVariation disease BEFREE These data suggest that genetic predisposition to the antitopo I response in PSS is associated most closely with the HLA-DQB1 locus. 1326003 1992