Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.500 AlteredExpression disease BEFREE Taken together, our results uncovered a mechanistic insight of a noncoding functional variant acting as an allele-specific distal enhancer to directly modulate IRF5 expression, which might obligate in understanding of complex genetic architectures of SLE and SSc pathogenesis. 31421124 2020
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.500 GeneticVariation disease GWASCAT Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases. 30573655 2019
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.500 GeneticVariation disease BEFREE Among eight SSc-associated susceptibility polymorphisms which were applied for meta-analysis, IRF5 rs2004640 polymorphism (OR 1.12; 95% CI 1.02-1.22, P = 1.39 × 10<sup>-2</sup>), STAT4 rs7574865 polymorphism (OR 1.25; 95% CI 1.07-1.47, P = 5.3 × 10<sup>-3</sup>), IRAK1 rs1059702 polymorphism (OR 1.20; 95% CI 1.05-1.37, P = 0.007), and CTGF G-945C polymorphism (OR 1.42; 95% CI 1.18-1.71, P = 0.002) are associated with PF status in SSc, while TNFAIP3 rs5029939, CD226 rs763361, CD247 rs2056626, and IRF5 rs10488631 polymorphisms are not. 28434122 2017
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.500 GeneticVariation disease BEFREE For IRF5 polymorphism, the T allele was shown to be strongly associated with increased SSc risk (OR = 1.27, 95% CI = 1.17-1.39, P < 0.00001). 26712637 2016
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.500 GeneticVariation disease BEFREE The present study aimed to examine whether the SSc-associated SNP rs2004640 of IRF5 gene confer susceptibility to SSc and clinical features of SSc in a Han Chinese population. 25572744 2015
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.500 GeneticVariation disease BEFREE This meta-analysis certified that IRF5 polymorphisms confer susceptibility to SLE, MS, and SSc. 25036352 2014
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.500 GeneticVariation disease BEFREE A meta-analysis of the allele frequencies was performed to analyse the overall effect of these IRF5 genetic variants on SSc. 23372721 2013
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.500 GeneticVariation disease BEFREE An SNP in the IRF5 promoter region (rs4728142), associated with lower IRF5 transcript levels, was predictive of longer survival and milder ILD in patients with SSc. 22440820 2012
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.500 GeneticVariation disease BEFREE Genetic studies in the systemic sclerosis (SSc), an autoimmune disease that clinically manifests with dermal and internal organ fibrosis and small vessel vasculopathy, have identified multiple susceptibility genes including HLA-class II, PTPN22, IRF5, and STAT4 which have also been associated with other autoimmune diseases, such as systemic lupus erythematosus (SLE). 19796918 2010
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.500 GeneticVariation disease BEFREE We identified an IRF5 risk haplotype "R" (p(adj) = 0.024, OR 1.23, 95% CI 1.07-1.40) and a mirrored protective haplotype "P" (p(adj) = 8.8 x 10(-3), OR 0.78, 95% CI 0.68-0.90) for SSc susceptibility. 20231204 2010
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.500 Biomarker disease CTD_human Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus. 20383147 2010
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.500 GeneticVariation disease BEFREE We undertook the present study to determine whether IRF5 polymorphisms are also associated with a predisposition to SSc in Japanese. 19479858 2009
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.500 GeneticVariation disease LHGDN Association between the IRF5 rs2004640 functional polymorphism and systemic sclerosis: a new perspective for pulmonary fibrosis. 19116937 2009
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.500 GeneticVariation disease BEFREE To determine whether the functional BANK1 variants rs3733197 and rs10516487 are associated with systemic sclerosis (SSc) in 2 European Caucasian populations and to investigate the putative gene-gene interactions between BANK1 and IRF5 as well as STAT4. 19877059 2009
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.500 GeneticVariation disease BEFREE The IRF5 rs2004640 GT substitution is associated with susceptibility to SSc. 19116937 2009
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.500 GeneticVariation disease BEFREE An additive effect of the STAT4 rs7574865 T allele and the IRF5 rs2004640 T allele was observed, resulting in a multiple increased 1.28-fold risk of SSc. 19644887 2009