Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3
0.170 GeneticVariation disease BEFREE Among these genes, IRF5, STAT4, and CD247 were replicated most frequently while SNPs rs35677470 in DNASE1L3, rs5029939 in TNFAIP3, and rs7574685 in STAT4 have the strongest associations with SSc. 28526340 2017
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3
0.170 GeneticVariation disease GWASCAT Transethnic meta-analysis identifies GSDMA and PRDM1 as susceptibility genes to systemic sclerosis. 28314753 2017
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3
0.170 GeneticVariation disease BEFREE Among eight SSc-associated susceptibility polymorphisms which were applied for meta-analysis, IRF5 rs2004640 polymorphism (OR 1.12; 95% CI 1.02-1.22, P = 1.39 × 10<sup>-2</sup>), STAT4 rs7574865 polymorphism (OR 1.25; 95% CI 1.07-1.47, P = 5.3 × 10<sup>-3</sup>), IRAK1 rs1059702 polymorphism (OR 1.20; 95% CI 1.05-1.37, P = 0.007), and CTGF G-945C polymorphism (OR 1.42; 95% CI 1.18-1.71, P = 0.002) are associated with PF status in SSc, while TNFAIP3 rs5029939, CD226 rs763361, CD247 rs2056626, and IRF5 rs10488631 polymorphisms are not. 28434122 2017
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3
0.170 GeneticVariation disease BEFREE Identification of an Association of TNFAIP3 Polymorphisms With Matrix Metalloproteinase Expression in Fibroblasts in an Integrative Study of Systemic Sclerosis-Associated Genetic and Environmental Factors. 26474180 2016
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3
0.170 Biomarker disease BEFREE Associations between SSc and TNFAIP3 or IRF8 were also detected in our Japanese population. 23124809 2013
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3
0.170 GeneticVariation disease BEFREE In the discovery sample, we observed that all tested TNFAIP3 variants were in linkage disequilibrium and were associated with SSc and various SSc subsets, including the polyautoimmune phenotype. 22488580 2012
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3
0.170 AlteredExpression disease BEFREE Within the largest group of genes related to the inflammatory response, differential expression of TNFα-induced protein 3 and prostaglandin-endoperoxide synthase 2 was observed in EPC-derived cells and skin tissue from patients with SSc. 21769840 2011
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3
0.170 GeneticVariation disease BEFREE The TNFAIP3 rs5029939 found to be associated with SSc in this first set was then genotyped in a second set of 465 patients with SSc and 182 controls from Germany and 184 patients with SSc and 124 controls from Italy. 20511617 2010