Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 149233
Gene Symbol: IL23R
IL23R
0.500 GeneticVariation disease BEFREE AS patients with PA showed an earlier age of disease onset (p=0.021), longer disease duration (p=0.020) and longer duration of AS symptoms from onset (p=0.034) than AS patients without PA. We found significant associations with the presence of PA at disease onset in 14 SNPs located in 10 genes: HLA-DQB2 (rs2857210 and rs9276615), HLA-DOB (rs2857151, rs2621332 and rs1383261), JAK2 (rs7857730), IL-23R (rs11209008 and rs10489630), CYP1B1 (rs1056836), NELL1 (rs8176786), KL (rs564481), and MEFV (rs224204), IL-2RB (rs743777) and IL-1A (rs1800587). 30299251 2019
Entrez Id: 149233
Gene Symbol: IL23R
IL23R
0.500 GeneticVariation disease BEFREE Interleukin-23 receptor polymorphism (rs10889677 A/C) in ankylosing spondylitis: Meta-analysis in Caucasian and Asian populations. 29198991 2018
Entrez Id: 149233
Gene Symbol: IL23R
IL23R
0.500 GeneticVariation disease BEFREE The association between IL-23R polymorphisms and AS was evaluated by odds ratio (OR) and 95% confidence intervals (95% CI). 29944013 2018
Entrez Id: 149233
Gene Symbol: IL23R
IL23R
0.500 GeneticVariation disease BEFREE We replicated associations between AS and the polymorphisms in TNF (rs1800629), TNFRSF1A (rs4149570), and IL23R (rs11209026). 30208882 2018
Entrez Id: 149233
Gene Symbol: IL23R
IL23R
0.500 Biomarker disease BEFREE The results suggested that the genetic susceptibility for AS is associated with the nine SNPs of IL-23R in overall population. 30322951 2018
Entrez Id: 149233
Gene Symbol: IL23R
IL23R
0.500 GeneticVariation disease BEFREE We first detected that rs6693831 and rs1884444 in IL-23R gene and rs2275913 in IL-17A gene have genetic association with AS. 29050281 2017
Entrez Id: 149233
Gene Symbol: IL23R
IL23R
0.500 GeneticVariation disease BEFREE Through mounting genetic investigations, it has been established that IL12B and IL23R gene single nucleotide polymorphisms have significant associations with autoimmune diseases including inflammatory bowel disease, psoriasis, and ankylosing spondylitis. 28276258 2017
Entrez Id: 149233
Gene Symbol: IL23R
IL23R
0.500 GeneticVariation disease BEFREE We used publicly available epigenomic information and historical genetic association data to identify a putative regulatory element (PRE) in the intergenic region between IL23R and IL12RB2, which includes two single-nucleotide polymorphisms (SNPs) independently associated with AS-rs924080 (P=2 × 10<sup>-3</sup>) and rs11578380 (P=2 × 10<sup>-4</sup>). 28381868 2017
Entrez Id: 149233
Gene Symbol: IL23R
IL23R
0.500 AlteredExpression disease BEFREE IL23R and IL12RB2 mRNA levels in CD4+ T cells were compared between cases homozygous for the AS-risk 'A' allele and the protective 'G' allele. 26916345 2016
Entrez Id: 149233
Gene Symbol: IL23R
IL23R
0.500 GeneticVariation disease GWASCAT Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. 26974007 2016
Entrez Id: 149233
Gene Symbol: IL23R
IL23R
0.500 GeneticVariation disease BEFREE Recent studies have suggested the association of IL-23R polymorphisms with bone and articular inflammation in diseases such as ankylosing spondylitis and rheumatoid arthritis. 26016922 2016
Entrez Id: 149233
Gene Symbol: IL23R
IL23R
0.500 Biomarker disease BEFREE Their gut origin, effector phenotype and expression of multiple AS-associated genes, such as IL7R and IL23R, makes them potential contributors to the pathogenesis of AS. 27165176 2016
Entrez Id: 149233
Gene Symbol: IL23R
IL23R
0.500 GeneticVariation disease BEFREE In contrast, IL-23R gene polymorphisms may serve a protective role in AS and IBD. 27458846 2016
Entrez Id: 149233
Gene Symbol: IL23R
IL23R
0.500 GeneticVariation disease GWASCAT Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases. 26301688 2015
Entrez Id: 149233
Gene Symbol: IL23R
IL23R
0.500 GeneticVariation disease BEFREE The subunit of IL-23 (IL12B) and its receptor (IL23R) gene single-nucleotide polymorphisms (SNPs) have been shown to be associated with several autoimmune diseases such as inflammatory bowel disease, psoriasis and ankylosing spondylitis. 24547735 2014
Entrez Id: 149233
Gene Symbol: IL23R
IL23R
0.500 GeneticVariation disease BEFREE Besides TNF, the IL-23/IL-17 axis is emerging as an important inflammatory pathway in SpA, as a SNP in the IL-23R locus has been associated with developing AS, mice overexpressing IL-23 develop SpA-like features and IL-17 blockade has been shown to be efficacious for AS patients in a phase II trial. 23969080 2014
Entrez Id: 149233
Gene Symbol: IL23R
IL23R
0.500 GeneticVariation disease BEFREE In this study, we evaluated five important single nucleotide polymorphisms (SNPs) of the IL-23R gene which confers susceptibility to AS, and its effects on the severity of the disease in HLA-B27 positive and negative patients and several subtypes of HLA-B27. 24998354 2014
Entrez Id: 149233
Gene Symbol: IL23R
IL23R
0.500 GeneticVariation disease GWASCAT Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci. 23749187 2013
Entrez Id: 149233
Gene Symbol: IL23R
IL23R
0.500 GeneticVariation disease BEFREE Marked diversity of IL23R gene haplotype variants in rheumatoid arthritis comparing with Crohn's disease and ankylosing spondylitis. 23054009 2013
Entrez Id: 149233
Gene Symbol: IL23R
IL23R
0.500 GeneticVariation disease BEFREE A 170-kb region containing IL23R and its flanking regions was sequenced in 50 patients with AS and 50 ethnically matched healthy control subjects from a Han Chinese population. 23606107 2013
Entrez Id: 149233
Gene Symbol: IL23R
IL23R
0.500 Biomarker disease BEFREE We found no evidence for an association between the other two SNPs of IL-23R and AS. 23840727 2013
Entrez Id: 149233
Gene Symbol: IL23R
IL23R
0.500 GeneticVariation disease BEFREE The nonsynonymous single-nucleotide polymorphism (SNP) rs11209026 (Arg381Gln) in the IL23R gene has reproducibly been shown to be associated with ankylosing spondylitis (AS). 23818276 2013
Entrez Id: 149233
Gene Symbol: IL23R
IL23R
0.500 GeneticVariation disease BEFREE Two single nucleotide polymorphisms (SNPs), rs1004819 and rs10889677, of the interleukin-23 receptor (IL-23R) gene have been shown to be associated with AS susceptibility in European populations. 23767933 2013
Entrez Id: 149233
Gene Symbol: IL23R
IL23R
0.500 GeneticVariation disease BEFREE Interleukin-23 receptor genetic polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis. 21253733 2012
Entrez Id: 149233
Gene Symbol: IL23R
IL23R
0.500 GeneticVariation disease BEFREE This meta-analysis shows that the IL-23R polymorphisms are associated with the development of AS in Europeans. 22089529 2012