Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.200 Biomarker disease BEFREE There was a significant overexpression of mRNAs of pro-inflammatory (IL-17A, IL-17F, IL-23, TNF-α and IFN-γ), while downregulation of anti-inflammatory cytokines (IL-10 and TGF-β) in PBMCs from 40 HLA-B27 positive AS patients in comparison to controls. 31711818 2020
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.200 AlteredExpression disease BEFREE Finally, IL-10 had significantly higher mRNA expression in AS patients with NBF (P < 0.01), and NF-κB had significantly higher mRNA expression in AS patients without NBF (P < 0.05) than healthy donors. 31348182 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.200 AlteredExpression disease BEFREE Serum IL-4 and IL-10 levels in AS patients were significantly increased, while IFN-γ and TNF-α expressions were depressed (p<0.05 compared to healthy controls). 30178829 2018
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.200 AlteredExpression disease BEFREE Abnormal activated B cells, dysregulated p38 expressions and decreased serum expressions of IL-10 were also observed in AS patients. 29771402 2018
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.200 AlteredExpression disease BEFREE There was a significant overexpression of mRNAs of IL-17A, IL-6, IL-33, TNF-α, and IFN-γ, while IL-10 was significantly downregulated in AS patients. 30518188 2018
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.200 GeneticVariation disease BEFREE In addition, the IL-10-819  C/T and TNF-α-857 C/T polymorphisms also confer susceptibility to AS, especially in Asian population. 30322951 2018
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.200 AlteredExpression disease BEFREE The levels of IL-4 and IL-10 were significantly low in the serum of patients with active AS, who also had high IFN-γ and TNF-α levels compared to those in the control individuals (P < 0.05). 28362980 2017
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.200 GeneticVariation disease GWASCAT Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. 26974007 2016
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.200 GeneticVariation disease BEFREE IL10 rs1878672 and rs3024490 polymorphisms obviously increase the susceptibility to AS, but not TNF-α rs3093662. 26823867 2015
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.200 Biomarker disease BEFREE TLR-4, IL-10 and HSPB1 gene expression increased significantly up to 3 h post treatment, with an earlier, higher and more pronounced increase of IL-10 in patients with AS. 25256892 2014
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.200 GeneticVariation disease BEFREE Three risk loci shared with ankylosing spondylitis and psoriasis (the MHC class I region, ERAP1 and IL23R and the MHC class I-ERAP1 interaction), as well as two loci shared with inflammatory bowel disease (IL23R and IL10) implicate shared pathogenic pathways in the spondyloarthritides and Behçet's disease. 23291587 2013
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.200 GeneticVariation disease BEFREE Macrophages from the synovial fluid of 5 patients with RA and 3 with seronegative SpA (2 with psoriatic arthritis and 1 with ankylosing spondylitis) were isolated by positive selection and stimulated ex vivo with IL-10 or interferon-gamma (IFNgamma). 16947381 2006
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.200 GeneticVariation disease BEFREE We conclude that IL10 promoter polymorphisms have no significant effect on susceptibility to AS, but may play a minor role in determining age of disease onset and disease severity. 12595905 2003
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.200 Biomarker disease BEFREE Genotypes and haplotypes of IL-10 were correlated with distinct features of the disease course, such as triggering agent, chronic arthritis, development of ankylosing spondylitis, and other chronic features. 11352256 2001
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.200 Biomarker disease BEFREE The percentage of IL10+/CD8+ T cells was higher in patients with AS than in both control groups. 11114280 2001