Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 64167
Gene Symbol: ERAP2
ERAP2
0.200 AlteredExpression disease BEFREE Results showed that the haplotype H4, containing ERAP1 SNPs associated with high enzymatic activity, together with the presence of ERAP2 expression, significantly increased the risk of AS (OR = 1.97, 95% CI = 1.21-3.21, p<sub>corr</sub> = 0.048). 30794838 2019
Entrez Id: 64167
Gene Symbol: ERAP2
ERAP2
0.200 Biomarker disease BEFREE Several large-scale genomic studies have identified association of members of this family of enzymes, most notably ERAP1 and ERAP2, with immune-mediated diseases including ankylosing spondylitis, psoriasis and birdshot chorioretinopathy. 30419264 2019
Entrez Id: 64167
Gene Symbol: ERAP2
ERAP2
0.200 Biomarker disease BEFREE Because most of the non-B*27 MHC-I molecules associated with AS risk bind a relatively high percentage of peptides with N-terminal basic residues, we hypothesize that the non-epistatic association of ERAP2 with AS might be related to the processing of peptides with these residues, thus affecting the peptidomes of AS-associated MHC-I molecules. 31530632 2019
Entrez Id: 64167
Gene Symbol: ERAP2
ERAP2
0.200 AlteredExpression disease BEFREE In accordance with studies demonstrating that polymorphisms that increase aminopeptidase activity predispose to immune disease, the increased risk also attributed to increased expression of ERAP1 and ERAP2 supports the notion of using aminopeptidase inhibition to treat AS and other ERAP-associated conditions. 29108111 2018
Entrez Id: 64167
Gene Symbol: ERAP2
ERAP2
0.200 GeneticVariation disease BEFREE ERAP1/ERAP2 and RUNX3 polymorphisms are not associated with ankylosing spondylitis susceptibility in Chinese Han. 29480940 2018
Entrez Id: 64167
Gene Symbol: ERAP2
ERAP2
0.200 GeneticVariation disease BEFREE GWAS have also shown the potential associations between ERAP single nucleotide polymorphisms (SNP) loci and susceptibility to several autoimmune diseases, and ERAP1 and ERAP2 polymorphisms are related to HLA class I-associated diseases, including ankylosing spondylitis and Behçet's disease. 28651467 2017
Entrez Id: 64167
Gene Symbol: ERAP2
ERAP2
0.200 GeneticVariation disease BEFREE Distribution of the ERAP2 SNPs rs2549782 and rs2248374 in patients with AS and in patients with Crohn's disease was assessed. 28029742 2017
Entrez Id: 64167
Gene Symbol: ERAP2
ERAP2
0.200 AlteredExpression disease BEFREE Both highly active ERAP1 variants and ERAP2 expression favor AS, whereas loss-of-function ERAP1 and loss-of-expression ERAP2 variants are protective. 28063628 2017
Entrez Id: 64167
Gene Symbol: ERAP2
ERAP2
0.200 Biomarker disease BEFREE These data support the notion of a peptide-mediated mechanism as the basis for the association of ERAP-2 with ankylosing spondylitis. 27110896 2016
Entrez Id: 64167
Gene Symbol: ERAP2
ERAP2
0.200 GeneticVariation disease GWASCAT Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. 26974007 2016
Entrez Id: 64167
Gene Symbol: ERAP2
ERAP2
0.200 GeneticVariation disease BEFREE It was found that single nucleotide polymorphisms (SNPs) of endoplasmic reticulum aminopeptidase (ERAP1 and ERAP2) genes influence the risk of ankylosing spondylitis, the most common form of SpA and the risk of psoriasis. 28083616 2016
Entrez Id: 64167
Gene Symbol: ERAP2
ERAP2
0.200 Biomarker disease BEFREE Large differences were not seen in HLA-B27 expression or cytokine levels between subjects with and without ERAP2 in AS cases and controls. 26088389 2015
Entrez Id: 64167
Gene Symbol: ERAP2
ERAP2
0.200 GeneticVariation disease GWASCAT Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases. 26301688 2015
Entrez Id: 64167
Gene Symbol: ERAP2
ERAP2
0.200 GeneticVariation disease GWASCAT Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci. 23749187 2013
Entrez Id: 64167
Gene Symbol: ERAP2
ERAP2
0.200 GeneticVariation disease BEFREE We studied the relationship of these serum cytokine receptors and their corresponding cytokines to markers of inflammation and polymorphisms in ERAP1 and ERAP2 in patients with AS. 20595269 2010
Entrez Id: 64167
Gene Symbol: ERAP2
ERAP2
0.200 Biomarker disease BEFREE ERAP1 and ERAP2 could carry out several potential roles in the pathogenesis of AS. 20531381 2010
Entrez Id: 64167
Gene Symbol: ERAP2
ERAP2
0.200 GeneticVariation disease BEFREE This study shows that one ERAP1 SNP and a haplotype in the ERAP1 and ERAP2 locus are associated with familial AS. 19433412 2010